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Tag Content
UUCD2 ID IUUC-Laf-053372
UUCD1 version UUC-LoA-00144
Ensembl Protein ID ENSLAFP00000003561.3
UniProt Accession G3STX9; G3STX9_LOXAF
Protein Name Uncharacterized protein
Gene Name HERC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSLAFG00000004263.3 ENSLAFT00000004270.3 ENSLAFP00000003561.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.80e-87 292.6 4468 4797
Active Site
Position(s) Description Evidence
4766 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
    ++++v+fvgE++ d+gG +e +a++++elqn ++l+ ++n++ + n+d +l +p h+++F+flG+llg+a+++g +l
   Q: 4468 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPaarapVHTSMFRFLGVLLGIAIRTGSPL 4554
    4566****************************************************99999999*********************** PP
   S: 89 dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
    l l+++++k+l g +l++ dl+evd++++ l++i++n+ ++ e +++ l f+ +++++ +++ +++++++t +N+ eYv+
   Q: 4555 SLSLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKHTHITLDNRAEYVR 4636
    ***************************************9999999999***99.....788999999******************* PP
   S: 176 lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
    l ++yrl+e ++eqv+a+reG+ +v+p llslFt ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFwev+e+fs++er+
   Q: 4637 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSAPLIQWFWEVMESFSNTERS 4721
    *********.**************************************************77.************************ PP
   S: 263 afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
    fL+Fv+g+ rlP + +a+++ r fvi+ + d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4722 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPKYSCKQVLEEKLKYAIHFCKSIDT 4797
    *************.8*************999988888***********************************99875 PP
   

Organism Loxodonta africana
Protein Sequence
(Fasta)
MPSDSFCLVA QARLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELTPNGELLP 60
RKDDGVDSQN GAKKEDLNDR EKKEEEEAPV PAHRAKSILE SWVWGKQPDV SELKECLTVL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Laf-053372|E3,HECT|Loxodonta africana
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCCTTCTG ATTCTTTCTG CTTGGTTGCC CAGGCTCGAC TTGACTCCAA ATGGTTGAAA 60
ACGGATATAC AGGTGGGATG TTGACATGCT TTTTTCTTGG TATTTTCATG CCTTACATTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Laf-053372|E3,HECT|Loxodonta africana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

KEGG lav:100662981
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 95.37 0.00e+00 7097.00
IUUC-Atr-003065 Amborella trichopoda 35.31 6.00e-51 196.00
IUUC-Apl-003983 Anas platyrhynchos 90.37 0.00e+00 8351.00
IUUC-Aca-004300 Anolis carolinensis 89.45 0.00e+00 8244.00
IUUC-Aly-006441 Arabidopsis lyrata 34.15 1.00e-44 175.00
IUUC-Ame-010621 Astyanax mexicanus 84.80 0.00e+00 6945.00
IUUC-Bta-013067 Bos taurus 94.58 0.00e+00 8552.00
IUUC-Bdi-014093 Brachypodium distachyon 33.51 3.00e-49 190.00
IUUC-Bol-015203 Brassica oleracea 34.55 1.00e-52 201.00
IUUC-Bra-016737 Brassica rapa 34.55 5.00e-48 186.00
IUUC-Cja-019687 Callithrix jacchus 93.38 0.00e+00 8389.00
IUUC-Cfa-020672 Canis familiaris 95.27 0.00e+00 8655.00
IUUC-Cpo-021819 Cavia porcellus 92.26 0.00e+00 8354.00
IUUC-Csa-023817 Chlorocebus sabaeus 95.06 0.00e+00 8594.00
IUUC-Cho-024387 Choloepus hoffmanni 95.76 0.00e+00 1931.00
IUUC-Cin-025709 Ciona intestinalis 58.97 0.00e+00 1441.00
IUUC-Csv-026336 Ciona savignyi 42.05 0.00e+00 3007.00
IUUC-Dre-027717 Danio rerio 82.33 0.00e+00 7306.00
IUUC-Dno-029296 Dasypus novemcinctus 95.21 0.00e+00 8657.00
IUUC-Dor-030979 Dipodomys ordii 89.35 0.00e+00 2854.00
IUUC-Dme-032171 Drosophila melanogaster 59.75 0.00e+00 1531.00
IUUC-Ete-032687 Echinops telfairi 86.41 0.00e+00 2912.00
IUUC-Eca-034046 Equus caballus 94.46 0.00e+00 8573.00
IUUC-Eeu-034859 Erinaceus europaeus 93.65 0.00e+00 1934.00
IUUC-Fca-036262 Felis catus 95.14 0.00e+00 8675.00
IUUC-Fal-037562 Ficedula albicollis 90.21 0.00e+00 8273.00
IUUC-Gmo-039054 Gadus morhua 87.09 0.00e+00 1093.00
IUUC-Gga-040359 Gallus gallus 90.48 0.00e+00 8301.00
IUUC-Gac-041879 Gasterosteus aculeatus 90.04 0.00e+00 1035.00
IUUC-Ggo-044692 Gorilla gorilla 96.25 0.00e+00 4289.00
IUUC-Hsa-045995 Homo sapiens 95.02 0.00e+00 8636.00
IUUC-Hvu-047529 Hordeum vulgare 35.65 4.00e-49 190.00
IUUC-Itr-048553 Ictidomys tridecemlineatus 94.01 0.00e+00 2404.00
IUUC-Lch-049808 Latimeria chalumnae 87.07 0.00e+00 3355.00
IUUC-Lpe-051482 Leersia perrieri 34.20 2.00e-46 181.00
IUUC-Loc-052685 Lepisosteus oculatus 84.63 0.00e+00 7575.00
IUUC-Mcc-054693 Macaca mulatta 95.04 0.00e+00 8635.00
IUUC-Meu-056660 Macropus eugenii 95.43 0.00e+00 1916.00
IUUC-Mga-059371 Meleagris gallopavo 90.75 0.00e+00 7171.00
IUUC-Mmr-060787 Microcebus murinus 95.60 0.00e+00 8735.00
IUUC-Mdo-062518 Monodelphis domestica 89.03 0.00e+00 8019.00
IUUC-Mmu-063690 Mus musculus 93.99 0.00e+00 8515.00
IUUC-Mpu-066478 Mustela putorius furo 94.84 0.00e+00 8586.00
IUUC-Mlu-067596 Myotis lucifugus 89.91 0.00e+00 4343.00
IUUC-Nle-069445 Nomascus leucogenys 95.06 0.00e+00 2170.00
IUUC-Opr-070990 Ochotona princeps 87.37 0.00e+00 2982.00
IUUC-Ont-072285 Oreochromis niloticus 82.99 0.00e+00 7368.00
IUUC-Oan-072721 Ornithorhynchus anatinus 86.28 0.00e+00 3439.00
IUUC-Ocu-074273 Oryctolagus cuniculus 94.41 0.00e+00 8602.00
IUUC-Oba-075573 Oryza barthii 33.68 1.00e-45 178.00
IUUC-Obr-076107 Oryza brachyantha 34.04 3.00e-50 194.00
IUUC-Ogl-077193 Oryza glaberrima 33.68 1.00e-45 178.00
IUUC-Ogu-078817 Oryza glumaepatula 33.68 1.00e-45 178.00
IUUC-Oin-079609 Oryza indica 33.00 4.00e-49 190.00
IUUC-Olo-080629 Oryza longistaminata 33.68 1.00e-45 178.00
IUUC-Ome-081686 Oryza meridionalis 33.68 5.00e-46 179.00
IUUC-Opu-084137 Oryza punctata 33.94 3.00e-46 180.00
IUUC-Oru-085013 Oryza rufipogon 33.68 1.00e-45 178.00
IUUC-Osa-085597 Oryza sativa 33.68 1.00e-45 178.00
IUUC-Ola-087346 Oryzias latipes 91.93 0.00e+00 1192.00
IUUC-Oga-088742 Otolemur garnettii 94.52 0.00e+00 8544.00
IUUC-Oar-090093 Ovis aries 94.67 0.00e+00 8574.00
IUUC-Ptr-091034 Pan troglodytes 89.82 0.00e+00 5651.00
IUUC-Pan-092783 Papio anubis 92.69 0.00e+00 8392.00
IUUC-Psi-094027 Pelodiscus sinensis 90.62 0.00e+00 7960.00
IUUC-Pfo-096208 Poecilia formosa 80.73 0.00e+00 6017.00
IUUC-Pab-097681 Pongo abelii 91.82 0.00e+00 2544.00
IUUC-Pca-100705 Procavia capensis 97.06 0.00e+00 1187.00
IUUC-Pva-103147 Pteropus vampyrus 86.77 0.00e+00 2495.00
IUUC-Rno-105458 Rattus norvegicus 93.96 0.00e+00 8498.00
IUUC-Sha-106959 Sarcophilus harrisii 81.52 0.00e+00 6996.00
IUUC-Sit-109917 Setaria italica 36.47 2.00e-48 187.00
IUUC-Sly-110961 Solanum lycopersicum 35.33 5.00e-53 203.00
IUUC-Sar-113532 Sorex araneus 84.89 0.00e+00 1807.00
IUUC-Sbi-114352 Sorghum bicolor 32.65 7.00e-50 192.00
IUUC-Ssc-115337 Sus scrofa 91.58 0.00e+00 2982.00
IUUC-Tgu-116789 Taeniopygia guttata 90.13 0.00e+00 8299.00
IUUC-Tru-118129 Takifugu rubripes 82.33 0.00e+00 7396.00
IUUC-Tsy-119302 Tarsius syrichta 84.61 0.00e+00 1264.00
IUUC-Tni-120374 Tetraodon nigroviridis 80.87 0.00e+00 7237.00
IUUC-Tca-121094 Theobroma cacao 35.31 1.00e-53 205.00
IUUC-Tae-124157 Triticum aestivum 33.77 2.00e-49 191.00
IUUC-Tbe-128137 Tupaia belangeri 86.92 0.00e+00 2304.00
IUUC-Ttr-128273 Tursiops truncatus 90.23 0.00e+00 6334.00
IUUC-Vpa-130471 Vicugna pacos 83.75 0.00e+00 1481.00
IUUC-Xtr-132185 Xenopus tropicalis 85.02 0.00e+00 7719.00
IUUC-Xma-133233 Xiphophorus maculatus 82.85 0.00e+00 7353.00
Created Date 25-Jun-2017

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