iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023378

Ensembl Protein ID

ENSCSAP00000002712.1

UniProt Accession

A0A0D9R273; A0A0D9R273_CHLSB

Genbank Protein ID

ENSCSAP00000002712

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01148292

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000006415.1	ENSCSAT00000004459.1	ENSCSAP00000002712.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-108	360.9	545	871

Active Site

Position(s)	Description	Evidence
840	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 545  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 628
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 629  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 715
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 716  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 804
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 805  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 871
           *****************...8888866666**************************************97 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MATACKRSGE PQSDDIEASR MKRAAAKHLI ERYYHQLTEG CGNEACTNEF CASCPTFLRM 60
DNNAAAIKAL ELYKINAKLC DPHPSKKGAS SAYLENSKGA PNNSCSEIKM NKKGTRIDFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAAAAATC TGTAAGAGCC TGATTTTAGA ATTCACCAGC TCCTCAGAAG TTTGGCGAAA 60
TATGGTATGT TTTTGTTTTA TTTTTTGGAA TTCGTATTGC ATGTGAAAAT ATCTTAATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	98.01	0.00e+00	1612.00
IUUC-Atr-003144	Amborella trichopoda	45.80	6.00e-96	344.00
IUUC-Apl-003742	Anas platyrhynchos	91.59	0.00e+00	1597.00
IUUC-Aca-004873	Anolis carolinensis	93.55	0.00e+00	1610.00
IUUC-Ani-009176	Aspergillus nidulans	33.11	9.00e-81	295.00
IUUC-Ame-011166	Astyanax mexicanus	86.71	0.00e+00	1453.00
IUUC-Bgr-011981	Blumeria graminis	32.95	3.00e-82	300.00
IUUC-Bta-013286	Bos taurus	97.15	0.00e+00	1590.00
IUUC-Bci-013697	Botrytis cinerea	35.32	2.00e-70	261.00
IUUC-Cja-019707	Callithrix jacchus	99.19	0.00e+00	1660.00
IUUC-Cfa-020154	Canis familiaris	97.59	0.00e+00	1619.00
IUUC-Cpo-021292	Cavia porcellus	97.42	0.00e+00	1599.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Cho-025059	Choloepus hoffmanni	93.57	0.00e+00	1510.00
IUUC-Cin-025643	Ciona intestinalis	45.03	0.00e+00	717.00
IUUC-Csv-026282	Ciona savignyi	45.10	0.00e+00	675.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	3.00e-101	363.00
IUUC-Dre-027901	Danio rerio	86.23	0.00e+00	1437.00
IUUC-Dno-029320	Dasypus novemcinctus	97.49	0.00e+00	1635.00
IUUC-Dor-030756	Dipodomys ordii	95.18	0.00e+00	743.00
IUUC-Dme-032035	Drosophila melanogaster	42.86	6.00e-166	578.00
IUUC-Eca-033843	Equus caballus	97.78	0.00e+00	1571.00
IUUC-Eeu-035109	Erinaceus europaeus	96.12	0.00e+00	1559.00
IUUC-Fca-036344	Felis catus	96.12	0.00e+00	1627.00
IUUC-Fal-036747	Ficedula albicollis	91.59	0.00e+00	1598.00
IUUC-Fox-037941	Fusarium oxysporum	33.23	7.00e-91	329.00
IUUC-Gmo-038840	Gadus morhua	63.58	0.00e+00	1105.00
IUUC-Gga-040399	Gallus gallus	91.48	0.00e+00	1596.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.79	0.00e+00	1390.00
IUUC-Ggo-044804	Gorilla gorilla	99.65	0.00e+00	1665.00
IUUC-Hsa-045727	Homo sapiens	99.65	0.00e+00	1665.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	94.26	0.00e+00	1516.00
IUUC-Lch-050197	Latimeria chalumnae	90.59	0.00e+00	1548.00
IUUC-Loc-052743	Lepisosteus oculatus	88.10	0.00e+00	1519.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	4.00e-57	217.00
IUUC-Laf-053615	Loxodonta africana	96.08	0.00e+00	1606.00
IUUC-Mcc-054934	Macaca mulatta	100.00	0.00e+00	1670.00
IUUC-Meu-056061	Macropus eugenii	90.14	0.00e+00	1427.00
IUUC-Mor-057045	Magnaporthe oryzae	36.76	2.00e-80	294.00
IUUC-Mga-059271	Meleagris gallopavo	90.10	0.00e+00	1567.00
IUUC-Mmr-061288	Microcebus murinus	98.73	0.00e+00	1655.00
IUUC-Mdo-062975	Monodelphis domestica	95.79	0.00e+00	1612.00
IUUC-Mmu-063674	Mus musculus	95.65	0.00e+00	1586.00
IUUC-Mpu-066568	Mustela putorius furo	98.17	0.00e+00	1654.00
IUUC-Mlu-067522	Myotis lucifugus	89.23	0.00e+00	1508.00
IUUC-Nle-069505	Nomascus leucogenys	99.65	0.00e+00	1665.00
IUUC-Opr-070570	Ochotona princeps	89.65	0.00e+00	1461.00
IUUC-Ont-071527	Oreochromis niloticus	84.53	0.00e+00	1463.00
IUUC-Oan-073446	Ornithorhynchus anatinus	91.15	0.00e+00	1065.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.81	0.00e+00	1637.00
IUUC-Ola-086996	Oryzias latipes	85.28	0.00e+00	1465.00
IUUC-Oga-088261	Otolemur garnettii	98.71	0.00e+00	1628.00
IUUC-Oar-090024	Ovis aries	97.15	0.00e+00	1590.00
IUUC-Ptr-090455	Pan troglodytes	99.65	0.00e+00	1665.00
IUUC-Pan-092509	Papio anubis	98.48	0.00e+00	1499.00
IUUC-Psi-092974	Pelodiscus sinensis	91.70	0.00e+00	1566.00
IUUC-Pma-094643	Petromyzon marinus	71.61	0.00e+00	1258.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	6.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	84.77	0.00e+00	1462.00
IUUC-Pab-097840	Pongo abelii	97.30	0.00e+00	1594.00
IUUC-Pca-100869	Procavia capensis	96.72	0.00e+00	1589.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	668.00
IUUC-Rno-105453	Rattus norvegicus	95.76	0.00e+00	1589.00
IUUC-Sce-106306	Saccharomyces cerevisiae	36.60	9.00e-65	241.00
IUUC-Sha-107651	Sarcophilus harrisii	95.79	0.00e+00	1612.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	33.15	9.00e-77	282.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	6.00e-116	411.00
IUUC-Sar-113293	Sorex araneus	97.19	0.00e+00	1595.00
IUUC-Ssc-115979	Sus scrofa	97.31	0.00e+00	1595.00
IUUC-Tgu-116901	Taeniopygia guttata	91.59	0.00e+00	1597.00
IUUC-Tru-118368	Takifugu rubripes	85.90	0.00e+00	1462.00
IUUC-Tsy-119516	Tarsius syrichta	94.71	0.00e+00	1517.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.72	0.00e+00	1454.00
IUUC-Tre-122108	Trichoderma reesei	39.76	9.00e-78	285.00
IUUC-Tbe-127484	Tupaia belangeri	92.44	0.00e+00	1106.00
IUUC-Ttr-129078	Tursiops truncatus	97.08	0.00e+00	1569.00
IUUC-Vda-129969	Verticillium dahliae	37.53	2.00e-83	304.00
IUUC-Vpa-130312	Vicugna pacos	89.80	0.00e+00	1352.00
IUUC-Xtr-132881	Xenopus tropicalis	91.16	0.00e+00	1551.00
IUUC-Xma-133122	Xiphophorus maculatus	84.54	0.00e+00	1456.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence