iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004762

UUCD1 version

UUC-AnC-00171

Ensembl Protein ID

ENSACAP00000007131.3

UniProt Accession

H9GCI4; H9GCI4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

sharpin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000007245.3	ENSACAT00000007286.3	ENSACAP00000007131.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	3.50e-12	45.6	387	414
ULD/UDP/UBQ/UBQ_Other	2.10e-10	40.3	217	288

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +a+W C++CTf+N+P +++CemCs+ R+
   Q: 387  QAGWPCPTCTFINKPTRPGCEMCSTDRP 414
           789**********************998 PP

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglk.dgstihll 70
           ++v+v+++  s + + +v+ ++t+a L++++++  g++p  qr+++ G++L  dd+tL++yg++ dg+t++l+
   Q: 217  MKVQVEDAMYSaSISTRVHTHTTIAALRQQVFQDYGFHPSVQRWVI-GQCLcVDDRTLSSYGIRrDGDTAFLY 288
           78999999999999999*****************************.**************995488888886 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAAPAGLVLL ASARAWVPRP ASPSQKKPRH PQQQHPQQQQ KRLLRLQLSA APGPERFRLG 60
LKGAPDSGTE TSLVEYSLKE ISYEVKTPTC HELKVLARPD DPLVFHFEDE QEAQKWWSVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCTC CGGCGGGCCT GGTGCTTCTG GCCTCGGCCC GGGCCTGGGT CCCGCGCCCG 60
GCCTCGCCCT CCCAGAAGAA GCCGCGGCAC CCGCAGCAGC AGCACCCGCA GCAGCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16764--Sharpin_PH
PF00641--zf-RanBP
PF13445--zf-RING_UBOX

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination

KEGG

acs:100564158

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003627	Anas platyrhynchos	85.11	7.00e-21	91.30
IUUC-Ame-011545	Astyanax mexicanus	49.42	7.00e-163	567.00
IUUC-Dre-028569	Danio rerio	52.43	0.00e+00	649.00
IUUC-Fal-037440	Ficedula albicollis	59.68	3.00e-19	85.90
IUUC-Gga-040198	Gallus gallus	57.43	2.00e-57	216.00
IUUC-Lch-050269	Latimeria chalumnae	53.80	0.00e+00	674.00
IUUC-Loc-052776	Lepisosteus oculatus	55.02	0.00e+00	664.00
IUUC-Meu-055912	Macropus eugenii	41.96	2.00e-37	149.00
IUUC-Mga-059615	Meleagris gallopavo	75.76	1.00e-27	113.00
IUUC-Ont-071314	Oreochromis niloticus	50.52	1.00e-174	606.00
IUUC-Ola-087012	Oryzias latipes	49.31	7.00e-174	603.00
IUUC-Pfo-096767	Poecilia formosa	51.04	0.00e+00	648.00
IUUC-Tru-118096	Takifugu rubripes	54.14	3.00e-161	561.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence