iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074770

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02022564

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000008013.3	ENSOCUT00000008017.3	ENSOCUP00000006928.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.90e-95	317.9	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+++  ledl+e+ p+  +sl+e++++  +d+ee+ ++l+f++  e++g t++++L+pgG+++ V +eN++e+v+++
   Q: 808  HFPLALYKKLLNVQPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGVTEQKKLIPGGDKVTVCKENRQEFVDAY 893
           *************************************99999997.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++ +i+e ++af++Gf +v+  ++l+lF+++el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYVFQVSIHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   ++i+  ++ +d lP ++TC+n+L+LP+Ysskeil  +L+ A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMGSLQ---IIIQStASGEDYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
           *******************...7888867888**************************************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MLCWGYWSLG QPGISSNLQG IVAEPQVCGF IADRSVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHER EGNKPEQIGA LADQHIVHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCCCAGAA GGACGCCCAT TGGCCACGTG GGAAGTCATT CACCCAGCGC ATTCCGCCGC 60
CCTCAGGCTC GCGGGGAAAC TTCCTTATTA TTGTGACGCC GAAAACGGAG AAACCCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ocu:100344750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	97.62	0.00e+00	2078.00
IUUC-Apl-003535	Anas platyrhynchos	88.29	0.00e+00	1885.00
IUUC-Aca-005223	Anolis carolinensis	85.33	0.00e+00	1836.00
IUUC-Ame-010816	Astyanax mexicanus	66.25	0.00e+00	1166.00
IUUC-Bta-013373	Bos taurus	97.05	0.00e+00	2073.00
IUUC-Cel-018150	Caenorhabditis elegans	33.21	4.00e-154	538.00
IUUC-Cja-019609	Callithrix jacchus	97.90	0.00e+00	2082.00
IUUC-Cfa-021071	Canis familiaris	97.43	0.00e+00	2075.00
IUUC-Cpo-021548	Cavia porcellus	96.67	0.00e+00	2064.00
IUUC-Csa-023987	Chlorocebus sabaeus	98.29	0.00e+00	2089.00
IUUC-Cho-024325	Choloepus hoffmanni	97.45	0.00e+00	1201.00
IUUC-Dre-027472	Danio rerio	66.44	0.00e+00	1399.00
IUUC-Dno-029241	Dasypus novemcinctus	96.29	0.00e+00	2049.00
IUUC-Dor-030672	Dipodomys ordii	91.53	0.00e+00	1127.00
IUUC-Dme-032103	Drosophila melanogaster	44.14	0.00e+00	843.00
IUUC-Ete-032642	Echinops telfairi	91.14	0.00e+00	1885.00
IUUC-Eca-033646	Equus caballus	97.62	0.00e+00	2078.00
IUUC-Eeu-035098	Erinaceus europaeus	84.41	0.00e+00	1375.00
IUUC-Fal-036952	Ficedula albicollis	88.48	0.00e+00	1885.00
IUUC-Gmo-039297	Gadus morhua	64.29	0.00e+00	1323.00
IUUC-Gga-040591	Gallus gallus	87.35	0.00e+00	1864.00
IUUC-Gac-041741	Gasterosteus aculeatus	64.99	0.00e+00	1382.00
IUUC-Gma-043616	Glycine max	37.79	8.00e-52	197.00
IUUC-Ggo-044769	Gorilla gorilla	98.00	0.00e+00	2081.00
IUUC-Hsa-046066	Homo sapiens	98.10	0.00e+00	2086.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	97.43	0.00e+00	2070.00
IUUC-Lch-050301	Latimeria chalumnae	73.62	0.00e+00	1622.00
IUUC-Loc-052803	Lepisosteus oculatus	67.53	0.00e+00	1456.00
IUUC-Laf-053364	Loxodonta africana	97.24	0.00e+00	2068.00
IUUC-Mcc-054930	Macaca mulatta	98.19	0.00e+00	2088.00
IUUC-Meu-056274	Macropus eugenii	78.90	0.00e+00	865.00
IUUC-Mtr-058277	Medicago truncatula	37.58	2.00e-52	199.00
IUUC-Mga-059563	Meleagris gallopavo	87.81	0.00e+00	1879.00
IUUC-Mmr-060792	Microcebus murinus	95.62	0.00e+00	2025.00
IUUC-Mdo-062195	Monodelphis domestica	90.96	0.00e+00	1943.00
IUUC-Mmu-063855	Mus musculus	94.67	0.00e+00	2035.00
IUUC-Mpu-066308	Mustela putorius furo	98.00	0.00e+00	2085.00
IUUC-Mlu-066927	Myotis lucifugus	96.86	0.00e+00	2061.00
IUUC-Nle-070090	Nomascus leucogenys	98.10	0.00e+00	2086.00
IUUC-Opr-070891	Ochotona princeps	86.57	0.00e+00	1778.00
IUUC-Ont-072201	Oreochromis niloticus	64.18	0.00e+00	1342.00
IUUC-Ola-086550	Oryzias latipes	65.25	0.00e+00	1389.00
IUUC-Olu-087836	Ostreococcus lucimarinus	34.14	3.00e-41	161.00
IUUC-Oga-088831	Otolemur garnettii	97.24	0.00e+00	2068.00
IUUC-Oar-090449	Ovis aries	97.14	0.00e+00	2067.00
IUUC-Pan-092135	Papio anubis	98.19	0.00e+00	2085.00
IUUC-Psi-093832	Pelodiscus sinensis	85.54	0.00e+00	1872.00
IUUC-Ppa-095354	Physcomitrella patens	32.69	1.00e-140	494.00
IUUC-Pfo-097268	Poecilia formosa	65.62	0.00e+00	1388.00
IUUC-Pab-098249	Pongo abelii	97.81	0.00e+00	2080.00
IUUC-Pca-100855	Procavia capensis	92.62	0.00e+00	1414.00
IUUC-Pva-102506	Pteropus vampyrus	89.06	0.00e+00	1831.00
IUUC-Rno-105242	Rattus norvegicus	94.95	0.00e+00	2080.00
IUUC-Sha-107186	Sarcophilus harrisii	88.77	0.00e+00	1191.00
IUUC-Sar-113612	Sorex araneus	95.65	0.00e+00	749.00
IUUC-Ssc-115473	Sus scrofa	97.14	0.00e+00	2071.00
IUUC-Tgu-116974	Taeniopygia guttata	88.68	0.00e+00	1863.00
IUUC-Tru-118077	Takifugu rubripes	63.93	0.00e+00	1320.00
IUUC-Tsy-119619	Tarsius syrichta	86.19	0.00e+00	1842.00
IUUC-Tni-120807	Tetraodon nigroviridis	63.77	0.00e+00	1339.00
IUUC-Tbe-127640	Tupaia belangeri	93.43	0.00e+00	1940.00
IUUC-Ttr-129172	Tursiops truncatus	96.38	0.00e+00	2053.00
IUUC-Vpa-130442	Vicugna pacos	81.73	0.00e+00	1679.00
IUUC-Xtr-132194	Xenopus tropicalis	71.60	0.00e+00	1444.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence