iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034098

UUCD1 version

UUC-EqC-00923

Ensembl Protein ID

ENSECAP00000017064.1

UniProt Accession

F7DYN4; F7DYN4_HORSE

Protein Name

Uncharacterized protein

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000019411.1	ENSECAT00000020769.1	ENSECAP00000017064.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-86	288.9	629	946

Active Site

Position(s)	Description	Evidence
917	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dl+k+l +ef +E   + gGv++ef++++++e+ ++++g+f y e+++++++p++ ++    e+ ++F ++G+l+g++l++ ++++l 
   Q: 629  TDLRKQLVIEFIKEIRPESGGVKSEFFHCIFEEMTKTEYGMFIYPEKGSCMWFPANPKF----EEKSYF-LFGMLCGLSLYNFNVVNLS 712
           6899****************************************************998....677888.55***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ +++k+ll++k sled++e+ p   k+l+ei++  +sdi e  + ++++       + ++++L+p+G ++ V+++Nk++Yv++ v+y
   Q: 713  FPLALFKKLLDQKPSLEDFKELSPLWGKNLQEILND-QSDIGEDYIYFSIH------WDHNDVDLIPDGISVLVNQNNKKDYVSKCVDY 794
           **********************************77.78999996555554......5778999************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
            +++++k  +e+f++Gf++v+++e+l+ F++eel + i G++++d+e+++k+ ky+  y++++++i +Fw+++++++ ee+k+fL F+T
   Q: 795  VFNTSVKAVYEEFQRGFYKVCDKEILRHFQPEELMTAIVGNTDYDWEQFEKNSKYTLPYHKSHRTIVMFWKAFHALTLEEKKKFLFFLT 883
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           g++rlP++G++e+   lf +++  s+++ P+s TC n L+LPeYs++  +ke L++Ai++++gF
   Q: 884  GNDRLPIRGLQEVG-ILFRCPETFSERDHPRSLTCHNILDLPEYSTMRRMKEALQVAINSNRGF 946
           **************.88999999***************************************99 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

EPIRTLETLR VSLVSCGQEH SLAVCHRGRV FAWGAGSEGQ LGTGEVKGIN FTPKKIKTLT 60
GIKIIQVSCG DYHSLALSEG GQVFSWGKNS QGQLGLGKEF PSQDSPQRVR SLEGIPLAQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACCGATTC GGACATTGGA AACTCTACGA GTCAGCCTCG TGAGCTGTGG GCAGGAGCAC 60
TCCTTGGCTG TCTGTCACAG AGGACGGGTC TTCGCGTGGG GCGCGGGCTC TGAAGGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	76.00	0.00e+00	1357.00
IUUC-Aca-004663	Anolis carolinensis	46.92	0.00e+00	811.00
IUUC-Bta-013080	Bos taurus	76.36	0.00e+00	1410.00
IUUC-Cja-018891	Callithrix jacchus	74.22	0.00e+00	1402.00
IUUC-Cfa-020763	Canis familiaris	74.45	0.00e+00	1328.00
IUUC-Cpo-022346	Cavia porcellus	70.26	0.00e+00	1370.00
IUUC-Csa-023049	Chlorocebus sabaeus	77.67	0.00e+00	1521.00
IUUC-Dno-029093	Dasypus novemcinctus	76.26	0.00e+00	1471.00
IUUC-Eeu-035028	Erinaceus europaeus	67.17	4.00e-151	528.00
IUUC-Fca-036283	Felis catus	77.75	0.00e+00	1430.00
IUUC-Ggo-045553	Gorilla gorilla	74.61	0.00e+00	1441.00
IUUC-Hsa-046396	Homo sapiens	77.28	0.00e+00	1512.00
IUUC-Loc-052700	Lepisosteus oculatus	41.73	0.00e+00	761.00
IUUC-Laf-054433	Loxodonta africana	71.09	0.00e+00	1417.00
IUUC-Mcc-055014	Macaca mulatta	74.54	0.00e+00	1454.00
IUUC-Mdo-061839	Monodelphis domestica	56.54	0.00e+00	967.00
IUUC-Mmu-064378	Mus musculus	65.93	0.00e+00	1221.00
IUUC-Mpu-066293	Mustela putorius furo	72.64	0.00e+00	1311.00
IUUC-Mlu-067407	Myotis lucifugus	75.18	0.00e+00	1431.00
IUUC-Nle-069978	Nomascus leucogenys	76.81	0.00e+00	1512.00
IUUC-Opr-070190	Ochotona princeps	57.89	4.00e-178	618.00
IUUC-Ont-071328	Oreochromis niloticus	38.33	4.00e-174	605.00
IUUC-Oga-088780	Otolemur garnettii	69.05	0.00e+00	1290.00
IUUC-Oar-090307	Ovis aries	76.46	0.00e+00	1451.00
IUUC-Ptr-091567	Pan troglodytes	77.57	0.00e+00	1513.00
IUUC-Pan-091802	Papio anubis	72.38	0.00e+00	1397.00
IUUC-Pab-098024	Pongo abelii	61.68	0.00e+00	1116.00
IUUC-Pca-100315	Procavia capensis	60.05	0.00e+00	864.00
IUUC-Pva-102382	Pteropus vampyrus	73.14	0.00e+00	1347.00
IUUC-Rno-105768	Rattus norvegicus	61.70	0.00e+00	1164.00
IUUC-Sha-106525	Sarcophilus harrisii	54.81	0.00e+00	1032.00
IUUC-Sar-113014	Sorex araneus	61.95	6.00e-165	574.00
IUUC-Vpa-130214	Vicugna pacos	72.93	0.00e+00	1349.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence