iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066293

Ensembl Protein ID

ENSMPUP00000002165.1

UniProt Accession

M3XSW5; M3XSW5_MUSPF

Genbank Protein ID

ENSMPUP00000002165

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01040776

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002187.1	ENSMPUT00000002209.1	ENSMPUP00000002165.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-79	267.5	689	1006

Active Site

Position(s)	Description	Evidence
977	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +l k l +ef +E      Gv  ef++ +++e+ ++++g+f y e+++++++p +  +    e+ ++F  +G+l+g++l ++++ +l
   Q: 689  NLCKGLVIEFIKEIRSPGYGVIAEFFYYIFEEMTKTEYGMFIYPEEGSYMWFPVSPVF----EKKRYFL-FGILCGLSLNNSNVANL 770
           5678899******988777***********************************9998....6788995.5**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           p++ +++k+llg+k sl+dl+e+ p l k+l+ ++e   +di e+ l++ fs++     + k+++L+p+G + pV ++Nk++Yv++ 
   Q: 771  PFPLALFKKLLGQKPSLQDLKELSPLLGKNLQVLNEA--DDIGEE-LCIYFSIH----WDKKDVDLIPNGISKPVDQSNKKDYVSAC 850
           ***********************************88..488886.9***9855....5779999********************** PP
   S: 178  veyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++y+++ ++k  +e+f++Gf++v+++e l++lF++eel   + G++++d+++++++ +y++gy++++p+i +Fw+++++++ ee+++
   Q: 851  IDYIFNISVKAVYEEFQRGFYKVCDKEiLVKLFQPEELMAAVVGNTDYDWKQFEENSQYDQGYHKSHPTILMFWKAFHKLTLEEKRK 937
           ***************************778********************************************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           fL F+ g++rlP++G +++   +f +++  +++++P++ TC + L+ P+Ys++e+++e L++Ai++++gF
   Q: 938  FLFFLRGNDRLPVRGKQQMG-IIFRCPETFRETDYPRALTCHSILDFPKYSTMEKVEEALQVAINSSRGF 1006
           ********************.778888899*************************************999 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MYLCWNTNRP GPLRRRPAGR GGAELRQAAS GERHSLLLLS NGELHSYGDN SHGQLGRRDV 60
QRQEQPKRIP ALETLRVDLV SCGKEHSLAV CYKGRVFAWG AGSEGQLGIG EFNEINLIPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACCTCT GCTGGAACAC CAACCGCCCA GGACCTCTGC GCCGGAGGCC GGCTGGCCGT 60
GGCGGTGCGG AGCTGCGACA GGCGGCCTCC GGGGAGCGCC ACTCCCTGCT GCTGCTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	84.17	0.00e+00	1597.00
IUUC-Aca-004663	Anolis carolinensis	46.44	0.00e+00	803.00
IUUC-Bta-013080	Bos taurus	70.40	0.00e+00	1352.00
IUUC-Cja-018891	Callithrix jacchus	68.42	0.00e+00	1330.00
IUUC-Cfa-020763	Canis familiaris	78.42	0.00e+00	1460.00
IUUC-Cpo-022346	Cavia porcellus	66.13	0.00e+00	1284.00
IUUC-Csa-023049	Chlorocebus sabaeus	71.43	0.00e+00	1440.00
IUUC-Dno-029093	Dasypus novemcinctus	69.77	0.00e+00	1367.00
IUUC-Eca-034098	Equus caballus	72.64	0.00e+00	1342.00
IUUC-Eeu-035028	Erinaceus europaeus	56.36	2.00e-143	503.00
IUUC-Fca-036283	Felis catus	79.09	0.00e+00	1463.00
IUUC-Ggo-045553	Gorilla gorilla	69.74	0.00e+00	1358.00
IUUC-Hsa-046396	Homo sapiens	71.75	0.00e+00	1417.00
IUUC-Loc-052700	Lepisosteus oculatus	40.00	0.00e+00	709.00
IUUC-Laf-054433	Loxodonta africana	67.02	0.00e+00	1358.00
IUUC-Mcc-055014	Macaca mulatta	68.00	0.00e+00	1375.00
IUUC-Mdo-061839	Monodelphis domestica	54.53	0.00e+00	984.00
IUUC-Mmu-064378	Mus musculus	61.86	0.00e+00	1172.00
IUUC-Mlu-067407	Myotis lucifugus	70.33	0.00e+00	1363.00
IUUC-Nle-069978	Nomascus leucogenys	71.12	0.00e+00	1427.00
IUUC-Opr-070190	Ochotona princeps	54.29	5.00e-175	608.00
IUUC-Oga-088780	Otolemur garnettii	64.35	0.00e+00	1223.00
IUUC-Oar-090307	Ovis aries	71.11	0.00e+00	1354.00
IUUC-Ptr-091567	Pan troglodytes	72.11	0.00e+00	1415.00
IUUC-Pan-091802	Papio anubis	67.25	0.00e+00	1336.00
IUUC-Pab-098024	Pongo abelii	58.81	0.00e+00	1080.00
IUUC-Pca-100315	Procavia capensis	56.38	0.00e+00	758.00
IUUC-Pva-102382	Pteropus vampyrus	68.23	0.00e+00	1296.00
IUUC-Rno-105768	Rattus norvegicus	58.87	0.00e+00	1129.00
IUUC-Sha-106525	Sarcophilus harrisii	51.73	0.00e+00	1003.00
IUUC-Sar-113014	Sorex araneus	58.25	7.00e-143	501.00
IUUC-Vpa-130214	Vicugna pacos	69.25	0.00e+00	1212.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence