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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063915
Ensembl Protein ID ENSMUSP00000042509.6
UniProt Accession Q8BH57; Q80TD4; Q80XI0; Q8BRM0; Q8CBK0; Q922Z9; Q9CRR1; Q9CSL0; WDR48_MOUSE
Genbank Protein ID BAC65793.3; BAB28345.1; BAB31193.3; BAC26755.1; BAC28400.1; BAC29010.1; BAC29218.1; BAC31719.1; AAH06679.1; AAH48155.1; AAH62967.1
Protein Name WD repeat-containing protein 48; USP1-associated factor 1
Genbank Nucleotide ID AK122511; AK012599; AK018396; AK030041; AK033631; AK035273; AK035864; AK043970; BC006679; BC048155; BC062967
Gene Name Wdr48; Kiaa1449; Uaf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032512.7 ENSMUST00000036561.7 ENSMUSP00000042509.6
ENSMUSG00000032512.7 ENSMUST00000217472.1 ENSMUSP00000150321.1
ENSMUSG00000032512.7 ENSMUST00000215307.1 ENSMUSP00000149478.1
ENSMUSG00000032512.7 ENSMUST00000215167.1 ENSMUSP00000149793.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-32 111.0 208 245
UBD/Beta-Prp 1.50e-47 163.3 31 294
ULD/UDP/UFD/RAWUL 2.20e-23 83.7 568 672
ULD/UBL/SUMO 6.50e-60 201.0 559 665
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
    gHtd v +l + d t +sGs Dgti++W+l +++++
   Q: 208 GHTDNVKALLLhRDgTQCLSGSSDGTIRLWSLGQQRCI 245
    8********88*888*****************999997 PP
   


   UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
    + +++++ p + l+t++rd+ i++w+v + k ++s++ h++ v++v + +gk+l+++s+D t+kvw+ +g c++tl+ h+d+
   Q: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY 119
    55677888888999*****************999999**************************************************** PP
   S: 97 vlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
    v +l++ ++++ ++s++ dr i +wd++t + l + lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t l +l+g
   Q: 120 VKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 208
    *********************************999*****999**********************************99999999999 PP
   S: 178 ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
    htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ + ++++sg+ D+ i++ dlr+ d+ + ++
   Q: 209 -HTDNVKALLLHRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEK 294
    .***********************************************************************999988876666666 PP
   


   ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy....................evdllcedevLedne 64
    L+p++s++ak+ lkk++l++s++l+V++++++++ek+++ s +++llc+d+vL++n+
   Q: 568 YLQPHASSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINldnesqttS--SsnnekpeqekeediavlaeeKIELLCQDQVLDPNM 651
    69**********...*************************99988766653..0457999999999*********************** PP
   S: 65 tLeeikyifiwkkegpLvLqYr 86
    +L+++ ++fiwk++g+L+L+Yr
   Q: 652 DLRTV-KHFIWKSGGDLTLHYR 672
    *****.***************9 PP
   


   ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcq.... 81
    ++kf+k+p++l++++++G+++l+k++lsa q++k+me+vY+k+inld++s+++++ +++ eqe++e+++v++e+kiellcq
   Q: 559 MPKFNKIPFYLQPHASSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQdqvl 647
    8********************************************************88888889********************7777 PP
   S: 82 ..............ksGG 85
    ksGG
   Q: 648 dpnmdlrtvkhfiwKSGG 665
    777777777777777776 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate.
Protein Sequence
(Fasta)
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN 60
QHKQDPYIAS MEHHTDWVND VVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063915|E3,WD_repeat;UBD,Beta-Prp;ULD,RAWUL;ULD,SUMO|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGAAGTGA CGTCGGAGTG TCAACATGCA AGATGGCGGC CCATCACCGG CAGAACACAG 60
CCGGGCGGAG GAAAGTGCAG GTATGGCGGC CCGGCTCCGC GGCCTTGGCG ACACTGCCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063915|E3,WD_repeat;UBD,Beta-Prp;ULD,RAWUL;ULD,SUMO|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0458--Lysosome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000724--P:double-strand break repair via homologous recombination
GO:0048568--P:embryonic organ development
GO:0048872--P:homeostasis of number of cells
GO:0008584--P:male gonad development
GO:0035264--P:multicellular organism growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0016579--P:protein deubiquitination
GO:1902525--P:regulation of protein monoubiquitination
GO:0072520--P:seminiferous tubule development
GO:0007338--P:single fertilization
GO:0048705--P:skeletal system morphogenesis
GO:0043588--P:skin development
GO:0007283--P:spermatogenesis

KEGG mmu:67561
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001160 Aegilops tauschii 40.24 2.00e-97 350.00
IUUC-Aml-001533 Ailuropoda melanoleuca 98.38 0.00e+00 1263.00
IUUC-Atr-003009 Amborella trichopoda 33.59 3.00e-109 389.00
IUUC-Apl-003709 Anas platyrhynchos 97.67 0.00e+00 662.00
IUUC-Aca-004875 Anolis carolinensis 96.90 0.00e+00 1280.00
IUUC-Aly-005464 Arabidopsis lyrata 39.81 4.00e-93 335.00
IUUC-Ath-006969 Arabidopsis thaliana 39.22 3.00e-89 323.00
IUUC-Acl-008203 Aspergillus clavatus 34.81 2.00e-46 181.00
IUUC-Afl-008571 Aspergillus flavus 34.73 3.00e-45 177.00
IUUC-Afu-009072 Aspergillus fumigatus 34.43 3.00e-44 174.00
IUUC-Ani-009413 Aspergillus nidulans 35.57 6.00e-47 182.00
IUUC-Ang-009571 Aspergillus niger 34.38 5.00e-44 173.00
IUUC-Aor-010064 Aspergillus oryzae 34.73 1.00e-45 178.00
IUUC-Ate-010463 Aspergillus terreus 34.13 5.00e-45 176.00
IUUC-Ame-010875 Astyanax mexicanus 93.57 0.00e+00 1084.00
IUUC-Bgr-012288 Blumeria graminis 33.72 5.00e-41 163.00
IUUC-Bta-013379 Bos taurus 98.67 0.00e+00 1265.00
IUUC-Bci-013859 Botrytis cinerea 31.82 1.00e-40 162.00
IUUC-Bdi-014645 Brachypodium distachyon 35.11 9.00e-113 401.00
IUUC-Bol-016450 Brassica oleracea 34.59 6.00e-99 355.00
IUUC-Bra-017237 Brassica rapa 34.56 4.00e-102 365.00
IUUC-Cel-018656 Caenorhabditis elegans 44.60 1.00e-155 543.00
IUUC-Cja-018804 Callithrix jacchus 98.38 0.00e+00 1262.00
IUUC-Cfa-020076 Canis familiaris 98.82 0.00e+00 1267.00
IUUC-Cpo-021721 Cavia porcellus 97.58 0.00e+00 1223.00
IUUC-Cre-022779 Chlamydomonas reinhardtii 30.66 5.00e-40 160.00
IUUC-Csa-023188 Chlorocebus sabaeus 98.82 0.00e+00 1267.00
IUUC-Cho-024932 Choloepus hoffmanni 97.64 0.00e+00 1271.00
IUUC-Cin-025591 Ciona intestinalis 56.57 0.00e+00 720.00
IUUC-Cgl-026540 Colletotrichum gloeosporioides 27.24 2.00e-20 94.70
IUUC-Cne-026819 Cryptococcus neoformans 35.53 5.00e-34 140.00
IUUC-Cme-027188 Cyanidioschyzon merolae 32.12 4.00e-70 259.00
IUUC-Dre-027926 Danio rerio 91.73 0.00e+00 1255.00
IUUC-Dno-029960 Dasypus novemcinctus 97.93 0.00e+00 1256.00
IUUC-Dor-030933 Dipodomys ordii 94.51 0.00e+00 708.00
IUUC-Dse-031532 Dothistroma septosporum 34.78 2.00e-45 177.00
IUUC-Dme-032168 Drosophila melanogaster 56.28 0.00e+00 682.00
IUUC-Ete-033107 Echinops telfairi 94.39 0.00e+00 1195.00
IUUC-Eca-034028 Equus caballus 98.67 0.00e+00 1265.00
IUUC-Eeu-034894 Erinaceus europaeus 96.61 0.00e+00 848.00
IUUC-Fca-035619 Felis catus 99.19 0.00e+00 950.00
IUUC-Fal-036869 Ficedula albicollis 96.98 0.00e+00 1248.00
IUUC-Fox-037907 Fusarium oxysporum 33.05 5.00e-41 163.00
IUUC-Fso-038101 Fusarium solani 32.77 3.00e-40 160.00
IUUC-Gmo-038627 Gadus morhua 93.80 0.00e+00 1274.00
IUUC-Ggr-039995 Gaeumannomyces graminis 31.01 1.00e-41 165.00
IUUC-Gga-040555 Gallus gallus 97.20 0.00e+00 1280.00
IUUC-Gac-042497 Gasterosteus aculeatus 93.50 0.00e+00 1243.00
IUUC-Gma-043089 Glycine max 34.29 3.00e-110 392.00
IUUC-Ggo-045561 Gorilla gorilla 98.82 0.00e+00 1267.00
IUUC-Hsa-045710 Homo sapiens 98.82 0.00e+00 1267.00
IUUC-Hvu-047730 Hordeum vulgare 35.82 8.00e-84 304.00
IUUC-Itr-049030 Ictidomys tridecemlineatus 98.52 0.00e+00 892.00
IUUC-Kpa-049237 Komagataella pastoris 30.77 6.00e-30 126.00
IUUC-Lch-049507 Latimeria chalumnae 94.53 0.00e+00 1251.00
IUUC-Lpe-051608 Leersia perrieri 35.15 2.00e-110 393.00
IUUC-Loc-052373 Lepisosteus oculatus 92.49 0.00e+00 1233.00
IUUC-Lma-053025 Leptosphaeria maculans 36.14 3.00e-48 187.00
IUUC-Laf-053706 Loxodonta africana 98.04 0.00e+00 1229.00
IUUC-Mcc-055046 Macaca mulatta 98.82 0.00e+00 1267.00
IUUC-Meu-056840 Macropus eugenii 78.92 5.00e-147 514.00
IUUC-Mor-057284 Magnaporthe oryzae 32.63 2.00e-42 167.00
IUUC-Mpo-057418 Magnaporthe poae 30.73 2.00e-40 160.00
IUUC-Mtr-058571 Medicago truncatula 34.34 2.00e-107 384.00
IUUC-Mla-059101 Melampsora laricipopulina 44.61 6.00e-45 177.00
IUUC-Mga-059297 Meleagris gallopavo 97.20 0.00e+00 1280.00
IUUC-Mvi-060419 Microbotryum violaceum 36.65 5.00e-38 153.00
IUUC-Mmr-061196 Microcebus murinus 91.86 0.00e+00 1138.00
IUUC-Mdo-062762 Monodelphis domestica 93.61 0.00e+00 1266.00
IUUC-Mac-065434 Musa acuminata 34.37 8.00e-107 381.00
IUUC-Mpu-065999 Mustela putorius furo 99.07 0.00e+00 845.00
IUUC-Mlu-068226 Myotis lucifugus 98.37 0.00e+00 1259.00
IUUC-Nfi-068416 Neosartorya fischeri 29.56 2.00e-55 211.00
IUUC-Ncr-068825 Neurospora crassa 31.05 7.00e-39 156.00
IUUC-Nle-069416 Nomascus leucogenys 98.82 0.00e+00 1267.00
IUUC-Opr-070515 Ochotona princeps 94.09 0.00e+00 1188.00
IUUC-Ont-072052 Oreochromis niloticus 91.34 0.00e+00 1186.00
IUUC-Oan-073636 Ornithorhynchus anatinus 93.96 0.00e+00 1239.00
IUUC-Ocu-074799 Oryctolagus cuniculus 98.67 0.00e+00 1264.00
IUUC-Oba-075146 Oryza barthii 35.19 7.00e-111 394.00
IUUC-Obr-076699 Oryza brachyantha 35.35 8.00e-112 397.00
IUUC-Ogl-077883 Oryza glaberrima 33.87 1.00e-67 250.00
IUUC-Ogu-078114 Oryza glumaepatula 35.19 2.00e-110 393.00
IUUC-Oin-079575 Oryza indica 35.53 4.00e-114 405.00
IUUC-Olo-080531 Oryza longistaminata 33.20 9.00e-101 361.00
IUUC-Ome-081368 Oryza meridionalis 40.87 4.00e-98 352.00
IUUC-Oni-082457 Oryza nivara 35.19 6.00e-111 395.00
IUUC-Opu-084050 Oryza punctata 35.05 6.00e-110 391.00
IUUC-Oru-084330 Oryza rufipogon 35.19 7.00e-111 394.00
IUUC-Osa-085408 Oryza sativa 35.53 4.00e-114 405.00
IUUC-Ola-087546 Oryzias latipes 93.13 0.00e+00 1244.00
IUUC-Olu-087710 Ostreococcus lucimarinus 31.38 3.00e-80 292.00
IUUC-Oga-087998 Otolemur garnettii 97.33 0.00e+00 1238.00
IUUC-Oar-090303 Ovis aries 98.67 0.00e+00 1265.00
IUUC-Ptr-090588 Pan troglodytes 98.82 0.00e+00 1267.00
IUUC-Pan-092722 Papio anubis 98.82 0.00e+00 1267.00
IUUC-Psi-093911 Pelodiscus sinensis 96.63 0.00e+00 1279.00
IUUC-Pma-094580 Petromyzon marinus 87.44 0.00e+00 1171.00
IUUC-Pno-095085 Phaeosphaeria nodorum 34.71 4.00e-43 170.00
IUUC-Ppa-095594 Physcomitrella patens 35.77 4.00e-113 402.00
IUUC-Pfo-096994 Poecilia formosa 93.26 0.00e+00 1240.00
IUUC-Pab-097586 Pongo abelii 98.67 0.00e+00 1264.00
IUUC-Pop-099740 Populus trichocarpa 34.51 1.00e-103 370.00
IUUC-Pca-100458 Procavia capensis 97.60 8.00e-106 377.00
IUUC-Ppe-102060 Prunus persica 33.76 2.00e-106 379.00
IUUC-Pva-102698 Pteropus vampyrus 94.09 0.00e+00 1244.00
IUUC-Pgr-103649 Puccinia graminis 34.12 2.00e-47 185.00
IUUC-Ptt-103910 Puccinia triticina 43.90 6.00e-53 203.00
IUUC-Pte-104181 Pyrenophora teres 36.14 3.00e-48 187.00
IUUC-Pyt-104439 Pyrenophora triticirepentis 36.14 6.00e-48 186.00
IUUC-Rno-104978 Rattus norvegicus 99.85 0.00e+00 1277.00
IUUC-Sha-107079 Sarcophilus harrisii 95.63 0.00e+00 1187.00
IUUC-Sja-107716 Schizosaccharomyces japonicus 30.16 3.00e-58 220.00
IUUC-Spo-108325 Schizosaccharomyces pombe 29.86 4.00e-51 196.00
IUUC-Ssl-108542 Sclerotinia sclerotiorum 29.04 9.00e-45 175.00
IUUC-Smo-109427 Selaginella moellendorffii 34.82 4.00e-109 389.00
IUUC-Sit-110755 Setaria italica 36.80 1.00e-115 410.00
IUUC-Sly-111099 Solanum lycopersicum 35.16 1.00e-97 350.00
IUUC-Sar-113408 Sorex araneus 99.23 0.00e+00 769.00
IUUC-Sbi-113789 Sorghum bicolor 35.38 3.00e-112 399.00
IUUC-Sre-114998 Sporisorium reilianum 39.60 1.00e-51 199.00
IUUC-Ssc-115434 Sus scrofa 98.82 0.00e+00 1267.00
IUUC-Tgu-116517 Taeniopygia guttata 97.19 0.00e+00 1283.00
IUUC-Tru-118174 Takifugu rubripes 93.68 0.00e+00 1248.00
IUUC-Tsy-118935 Tarsius syrichta 98.52 0.00e+00 1285.00
IUUC-Tni-119744 Tetraodon nigroviridis 94.09 0.00e+00 1222.00
IUUC-Tca-121360 Theobroma cacao 33.98 6.00e-111 395.00
IUUC-Tre-122198 Trichoderma reesei 32.29 1.00e-42 169.00
IUUC-Tvi-122389 Trichoderma virens 32.29 1.00e-42 168.00
IUUC-Tae-125576 Triticum aestivum 35.56 8.00e-113 401.00
IUUC-Tur-126699 Triticum urartu 35.28 4.00e-111 395.00
IUUC-Tme-126932 Tuber melanosporum 31.29 3.00e-54 207.00
IUUC-Tbe-127267 Tupaia belangeri 98.32 0.00e+00 691.00
IUUC-Ttr-129153 Tursiops truncatus 98.23 0.00e+00 1290.00
IUUC-Uma-129604 Ustilago maydis 40.89 2.00e-49 191.00
IUUC-Vda-129925 Verticillium dahliae 34.20 4.00e-45 177.00
IUUC-Vpa-130553 Vicugna pacos 97.91 0.00e+00 976.00
IUUC-Vvi-130995 Vitis vinifera 34.11 2.00e-106 380.00
IUUC-Xtr-132346 Xenopus tropicalis 93.07 0.00e+00 1222.00
IUUC-Xma-134266 Xiphophorus maculatus 91.60 0.00e+00 663.00
IUUC-Yli-134451 Yarrowia lipolytica 30.89 4.00e-35 143.00
IUUC-Zma-135647 Zea mays 35.66 7.00e-114 404.00
Created Date 25-Jun-2017

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