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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064285
Ensembl Protein ID ENSMUSP00000062464.7
UniProt Accession Q62415; ASPP1_MOUSE
Genbank Protein ID AAH54788.1; AAH53092.1; AAC52638.1
Protein Name Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B
Genbank Nucleotide ID BC054788; BC053092; U58881
Gene Name Ppp1r13b; Aspp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021285.14 ENSMUST00000054815.13 ENSMUSP00000062464.7
ENSMUSG00000021285.14 ENSMUST00000163747.2 ENSMUSP00000130017.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.20e-13 49.4 1017 1071
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
           +k +v +l+dyeaqn+deL++++Gd ++++  k+e++ +W+ +   l  ++G +P+n
   Q: 1017 NKGTVYALWDYEAQNSDELSFHEGDAITILrRKDENETEWWWA--RLGDREGYVPKN 1071
           567899************************99*********99..8**********9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity).
 Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity).
Protein Sequence
(Fasta)
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GGCHLAEVWR GSERPIPYDH 60
MMYEHLQKWG PRREEVKFFL RHEDSPTESS EQGARQTQEQ RTQRSVVNVP GEKRTENGVG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064285|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCGGCTGA GGGACGGCGA CGCGGCACGC GGGGCGGCGC GACAGGACGA GCGAGGGCTG 60
CGCGGCTCTC CGCAGCTGCC GCCTCGCCGC AGCCGGGCCG CAGGGCGCCG CAGCGGGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064285|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028319--ASPP_1
IPR001452--SH3_domain
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3
Pfam

PF12796--Ank_2
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00248--ANK
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045786--P:negative regulation of cell cycle
GO:1901216--P:positive regulation of neuron death
KEGG mmu:21981
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001642 Ailuropoda melanoleuca 88.38 0.00e+00 1781.00
IUUC-Apl-004077 Anas platyrhynchos 80.15 0.00e+00 1576.00
IUUC-Aca-004550 Anolis carolinensis 70.93 0.00e+00 1442.00
IUUC-Ame-011289 Astyanax mexicanus 66.10 0.00e+00 649.00
IUUC-Bta-012477 Bos taurus 87.86 0.00e+00 1697.00
IUUC-Cel-018245 Caenorhabditis elegans 50.28 1.00e-52 201.00
IUUC-Cja-019672 Callithrix jacchus 91.35 0.00e+00 1765.00
IUUC-Cfa-020703 Canis familiaris 89.37 0.00e+00 1736.00
IUUC-Cpo-022364 Cavia porcellus 91.57 0.00e+00 1755.00
IUUC-Csa-023051 Chlorocebus sabaeus 91.93 0.00e+00 1789.00
IUUC-Csv-025927 Ciona savignyi 47.98 4.00e-99 356.00
IUUC-Dre-028426 Danio rerio 61.04 0.00e+00 1133.00
IUUC-Dor-030295 Dipodomys ordii 83.78 0.00e+00 1108.00
IUUC-Eca-033910 Equus caballus 90.10 0.00e+00 1724.00
IUUC-Eeu-035287 Erinaceus europaeus 79.63 0.00e+00 894.00
IUUC-Fca-035913 Felis catus 89.54 0.00e+00 1739.00
IUUC-Fal-036698 Ficedula albicollis 80.58 0.00e+00 1574.00
IUUC-Gga-041256 Gallus gallus 76.15 0.00e+00 1559.00
IUUC-Gac-041539 Gasterosteus aculeatus 63.40 0.00e+00 1180.00
IUUC-Ggo-045619 Gorilla gorilla 92.09 0.00e+00 1700.00
IUUC-Hsa-046506 Homo sapiens 91.83 0.00e+00 1755.00
IUUC-Itr-048178 Ictidomys tridecemlineatus 86.81 0.00e+00 952.00
IUUC-Lch-050122 Latimeria chalumnae 74.73 0.00e+00 1539.00
IUUC-Loc-052306 Lepisosteus oculatus 58.15 0.00e+00 763.00
IUUC-Laf-053834 Loxodonta africana 87.67 0.00e+00 1694.00
IUUC-Mcc-055785 Macaca mulatta 91.74 0.00e+00 1756.00
IUUC-Meu-056089 Macropus eugenii 71.83 4.00e-146 512.00
IUUC-Mga-059590 Meleagris gallopavo 79.60 0.00e+00 1438.00
IUUC-Mmr-060975 Microcebus murinus 91.47 0.00e+00 1737.00
IUUC-Mdo-062632 Monodelphis domestica 80.79 0.00e+00 1653.00
IUUC-Mpu-066414 Mustela putorius furo 87.80 0.00e+00 1724.00
IUUC-Mlu-068059 Myotis lucifugus 84.88 0.00e+00 1675.00
IUUC-Opr-070603 Ochotona princeps 83.58 0.00e+00 1444.00
IUUC-Ont-072410 Oreochromis niloticus 61.92 0.00e+00 1127.00
IUUC-Ocu-074964 Oryctolagus cuniculus 87.03 0.00e+00 1655.00
IUUC-Ola-087385 Oryzias latipes 61.28 0.00e+00 1077.00
IUUC-Oga-088492 Otolemur garnettii 89.65 0.00e+00 1780.00
IUUC-Ptr-091354 Pan troglodytes 92.20 0.00e+00 1756.00
IUUC-Pan-092354 Papio anubis 91.83 0.00e+00 1759.00
IUUC-Psi-093223 Pelodiscus sinensis 80.27 0.00e+00 1609.00
IUUC-Pfo-097053 Poecilia formosa 53.19 0.00e+00 714.00
IUUC-Pab-097758 Pongo abelii 91.71 0.00e+00 1076.00
IUUC-Pca-100736 Procavia capensis 80.69 0.00e+00 723.00
IUUC-Pva-102307 Pteropus vampyrus 88.50 0.00e+00 958.00
IUUC-Rno-105716 Rattus norvegicus 97.24 0.00e+00 1846.00
IUUC-Sha-107553 Sarcophilus harrisii 81.43 0.00e+00 1573.00
IUUC-Ssc-115833 Sus scrofa 79.61 0.00e+00 1392.00
IUUC-Tgu-116995 Taeniopygia guttata 80.77 0.00e+00 1578.00
IUUC-Tru-117861 Takifugu rubripes 61.49 0.00e+00 1158.00
IUUC-Tni-120130 Tetraodon nigroviridis 63.47 0.00e+00 1185.00
IUUC-Tbe-127866 Tupaia belangeri 87.23 0.00e+00 1086.00
IUUC-Xtr-132886 Xenopus tropicalis 73.42 0.00e+00 1429.00
Created Date 25-Jun-2017

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