iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132065

UUCD1 version

UUC-XeT-00785

Ensembl Protein ID

ENSXETP00000030258.2

UniProt Accession

Q28BW8; Q28BW8_XENTR

Genbank Protein ID

AAI21308.1; CAJ83583.1

Protein Name

LON peptidase N-terminal domain and ring finger 2; Ring finger protein 127

Genbank Nucleotide ID

AAMC01074074; CR942594

Gene Name

lonrf2; LOC733984; rnf127; TGas004f02.1-001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000013825.2	ENSXETT00000030258.2	ENSXETP00000030258.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.00e-09	38.5	475	521
E3 activity/RING/RING	1.60e-06	28.7	478	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplte 52
           +f C++ + l+ +Pv +p+G+t+  +++e++l+++ + cP++++ l++
   Q: 475  DFECSLCMRLFYEPVATPCGHTFCLKCLERCLDHNPH-CPLCKEDLAQ 521
           699**********************************.******9965 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+  f + p+ +pCgH+f+++Cl++          + +CPlC+
   Q: 478  CSLCMRLFYE-PVATPCGHTFCLKCLERC------LDHNPHCPLCK 516
           ****999977.999************999......9*********7 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MEVGSVQHTD PFPPAPPGLC SEMLGVAEES YRAGNFELAA EIYGSQLEEQ PQRFLWLRKG 60
DALALAGRVT DALDCYTRAA MLSQLRPEEL GVLVGSIARN IREKELGLPC AQREPGTAHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATGTGCCG ATCTAAGGAC AGAAGACAGG CAGGCAGGGT GAGCTTGATC GAAACTACTG 60
GGGATTGTTG GAAAAGTTAA AATAGACACA GTGGGCCCTT ATAATCTGTG GGCCCCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51787--LON_N
PS50293--TPR_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02190--LON_substr_bdg
PF13445--zf-RING_UBOX

SMART

SM00464--LON
SM00184--RING
SM00028--TPR

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

xtr:733984

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001867	Ailuropoda melanoleuca	53.26	5.00e-174	603.00
IUUC-Apl-003355	Anas platyrhynchos	69.72	0.00e+00	752.00
IUUC-Aca-004822	Anolis carolinensis	61.49	0.00e+00	846.00
IUUC-Ame-010750	Astyanax mexicanus	57.54	0.00e+00	793.00
IUUC-Cel-018356	Caenorhabditis elegans	32.53	2.00e-09	54.70
IUUC-Cja-019041	Callithrix jacchus	48.67	9.00e-174	603.00
IUUC-Cfa-020025	Canis familiaris	52.40	1.00e-172	599.00
IUUC-Cin-025668	Ciona intestinalis	36.65	2.00e-107	383.00
IUUC-Csv-026364	Ciona savignyi	43.89	4.00e-78	284.00
IUUC-Cne-026875	Cryptococcus neoformans	27.38	4.00e-07	50.10
IUUC-Dre-028400	Danio rerio	61.90	3.00e-179	621.00
IUUC-Dse-031331	Dothistroma septosporum	32.73	3.00e-38	152.00
IUUC-Dme-031919	Drosophila melanogaster	37.68	2.00e-67	251.00
IUUC-Fca-036276	Felis catus	53.33	3.00e-178	618.00
IUUC-Fal-036669	Ficedula albicollis	67.75	0.00e+00	766.00
IUUC-Fso-038334	Fusarium solani	41.06	1.00e-42	167.00
IUUC-Gga-041253	Gallus gallus	63.01	0.00e+00	842.00
IUUC-Gac-041782	Gasterosteus aculeatus	50.89	0.00e+00	668.00
IUUC-Ggo-045501	Gorilla gorilla	49.39	0.00e+00	637.00
IUUC-Hsa-046630	Homo sapiens	49.53	0.00e+00	634.00
IUUC-Itr-048224	Ictidomys tridecemlineatus	53.98	1.00e-154	539.00
IUUC-Lch-049788	Latimeria chalumnae	58.29	0.00e+00	825.00
IUUC-Loc-051922	Lepisosteus oculatus	57.23	0.00e+00	794.00
IUUC-Laf-054421	Loxodonta africana	40.65	7.00e-145	507.00
IUUC-Mcc-054828	Macaca mulatta	55.53	6.00e-157	546.00
IUUC-Meu-055901	Macropus eugenii	47.65	7.00e-153	533.00
IUUC-Mga-059760	Meleagris gallopavo	69.47	0.00e+00	744.00
IUUC-Mvi-060228	Microbotryum violaceum	32.72	3.00e-49	190.00
IUUC-Mdo-062203	Monodelphis domestica	60.80	0.00e+00	801.00
IUUC-Mmu-064118	Mus musculus	54.64	2.00e-155	541.00
IUUC-Mpu-065764	Mustela putorius furo	50.68	0.00e+00	632.00
IUUC-Nle-069616	Nomascus leucogenys	48.79	0.00e+00	634.00
IUUC-Ont-072142	Oreochromis niloticus	56.11	0.00e+00	809.00
IUUC-Ola-086534	Oryzias latipes	51.44	0.00e+00	718.00
IUUC-Oga-088972	Otolemur garnettii	49.13	2.00e-179	622.00
IUUC-Ptr-090992	Pan troglodytes	53.29	5.00e-169	587.00
IUUC-Pan-092180	Papio anubis	48.52	2.00e-179	622.00
IUUC-Psi-093423	Pelodiscus sinensis	70.96	0.00e+00	746.00
IUUC-Pma-094231	Petromyzon marinus	64.96	1.00e-114	405.00
IUUC-Pno-094889	Phaeosphaeria nodorum	33.86	1.00e-39	157.00
IUUC-Pfo-096363	Poecilia formosa	56.74	0.00e+00	793.00
IUUC-Pab-097974	Pongo abelii	48.91	0.00e+00	633.00
IUUC-Pva-102269	Pteropus vampyrus	47.89	1.00e-172	600.00
IUUC-Pte-104214	Pyrenophora teres	36.59	3.00e-37	149.00
IUUC-Pyt-104565	Pyrenophora triticirepentis	36.59	2.00e-37	150.00
IUUC-Tgu-117000	Taeniopygia guttata	67.64	0.00e+00	797.00
IUUC-Tru-118016	Takifugu rubripes	55.10	0.00e+00	757.00
IUUC-Ttr-128666	Tursiops truncatus	47.48	2.00e-165	575.00
IUUC-Vda-129721	Verticillium dahliae	29.26	2.00e-36	146.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence