iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011773

Ensembl Protein ID

ENSAMXP00000019569.1

UniProt Accession

W5LIA7; W5LIA7_ASTMX

Genbank Protein ID

ENSAMXP00000019569

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01090927

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000019004.1	ENSAMXT00000019569.1	ENSAMXP00000019569.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	1.20e-144	481.5	166	468
E3 adaptor/Cullin RING/DCX/DWD	1.00e-27	95.2	301	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+kvldapel+ddfylnL+dWs+ n l+v+Lg++vylwsa+t++v++l+dl  ++d+vtsv w e+g+l+avGt+kg v+i+D++  +k
   Q: 166  PFKVLDAPELQDDFYLNLVDWSAGNLLSVGLGACVYLWSACTSQVTRLCDLsVDGDSVTSVCWNERGSLVAVGTHKGFVQIWDAAGGRK 254
           689************************************************999*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdasssePlkkfke 177
           + +l+ghsarvgaL+Wn e+lssGsrd+ il+rdvr++  + ++lq+h+qevCGlkw+ d+++LasGGnDn++ vw++ss +P+++++e
   Q: 255  LTSLEGHSARVGALAWNGEQLSSGSRDRVILQRDVRTPPPMERKLQGHRQEVCGLKWSPDHQHLASGGNDNKLLVWNSSSLQPVQQYSE 343
           ***************************************************************************************** PP
   S: 178  hkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgh 266
           h aavkaiawsP+q++lLasGGGtaDrc++fwntltg+ l++ dtgsqvc+l+wsk+++elvsthG+++n+i +wkypsl++va+l+gh
   Q: 344  HLAAVKAIAWSPHQHGLLASGGGTADRCLRFWNTLTGQALQSTDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH 432
           ***************************************************************************************** PP
   S: 267  eaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           ++Rvl+la+spdgeaivt+agDetlrfw++f+k++ 
   Q: 433  SYRVLYLAVSPDGEAIVTGAGDETLRFWNVFSKTRC 468
           ********************************9875 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH  +v++l++ +d  +l+sG++D+++ vW+ ++  
   Q: 301  GHRQEVCGLKWsPDhQHLASGGNDNKLLVWNSSSLQ 336
           8***********999***************976655 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MDQDYERRLL RQINHQNVPE GQLTKSGYAP VSVKSGDRFI PTRAGSNWSI NFHYANENCW 60
SPNQNQRSKD ASADTGKDAV AYAALLRNEL LGAGIETVPD PHTDDRRQAI LSQDTHSLFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGATAGAT AGATAGATAG ATAGATAGAT AGATAGATAG ATAGATAGTT GTAGAGGGTG 60
TTGGGTGAGT AGTGTGAGCT GCAGCGCCCC CGCGTGGCCG CTGTCTCTCT AGCGCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0097027--F:ubiquitin-protein transferase activator activity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004920	Anolis carolinensis	46.77	5.00e-83	301.00
IUUC-Dre-027860	Danio rerio	96.10	0.00e+00	956.00
IUUC-Gmo-039431	Gadus morhua	84.80	0.00e+00	856.00
IUUC-Gac-041566	Gasterosteus aculeatus	91.17	0.00e+00	881.00
IUUC-Hvu-047486	Hordeum vulgare	66.67	5.00e-107	380.00
IUUC-Loc-052240	Lepisosteus oculatus	86.01	0.00e+00	868.00
IUUC-Lma-052998	Leptosphaeria maculans	42.73	2.00e-74	273.00
IUUC-Ont-071725	Oreochromis niloticus	92.61	0.00e+00	934.00
IUUC-Ola-086983	Oryzias latipes	90.85	0.00e+00	916.00
IUUC-Olu-087647	Ostreococcus lucimarinus	53.13	3.00e-100	358.00
IUUC-Pfo-096991	Poecilia formosa	90.76	0.00e+00	878.00
IUUC-Sce-106240	Saccharomyces cerevisiae	47.54	6.00e-95	341.00
IUUC-Spo-108056	Schizosaccharomyces pombe	48.26	2.00e-114	405.00
IUUC-Sbi-114489	Sorghum bicolor	54.61	2.00e-123	436.00
IUUC-Tru-118528	Takifugu rubripes	89.25	0.00e+00	872.00
IUUC-Tni-120312	Tetraodon nigroviridis	90.16	0.00e+00	866.00
IUUC-Tur-126545	Triticum urartu	59.19	9.00e-104	370.00
IUUC-Xma-134279	Xiphophorus maculatus	90.35	0.00e+00	907.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence