iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037477

Ensembl Protein ID

ENSFALP00000006569.1

UniProt Accession

U3JUW5; U3JUW5_FICAL

Genbank Protein ID

ENSFALP00000006569

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000328

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000006298.1	ENSFALT00000006598.1	ENSFALP00000006569.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-101	337.9	530	867

Active Site

Position(s)	Description	Evidence
835	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp + +    +lk++ef+Grl+gk+l+++     
   Q: 530  SDWSKNFEVIFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPGRPT--YLRLKVYEFAGRLVGKCLYESslgga 616
           7999**************************************888999**********985..59******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ ++  +  k++eL+ gG+++pVtneNk 
   Q: 617  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DVSEMDLVFAEEKYSKTGQLEKVVELVAGGAQVPVTNENKI 702
           99***********************************99****99...9*********9999999999********************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 703  LYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 791
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 792  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 867
           ************************99555555.**************************************9***97 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MFVPDLGSKW KDAEEWVPTF WLLGHGHLCK DAAVILGCVS HRRDLMFYII GGITVSVVAF 60
FFTIKFLFEL AARIVSFLQH EDRERRGERT IYDYVRGNYL DPRSCKISWD WKDPYEVGHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAGCTAGC AAACTGCAGG TTAAAGGAAA CAGCACAGCA GGCCAACCCT TTTCCCACAA 60
AGAGGAAGAA ACTGCGGTGC TCAAGTCTTT ATTTTACAGC AGTGATTCTG TGATGCAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

fab:101805860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	92.09	0.00e+00	1557.00
IUUC-Apl-004071	Anas platyrhynchos	96.60	0.00e+00	1539.00
IUUC-Aca-005218	Anolis carolinensis	94.66	0.00e+00	1539.00
IUUC-Ame-011871	Astyanax mexicanus	79.19	0.00e+00	1402.00
IUUC-Bta-012978	Bos taurus	91.49	0.00e+00	1550.00
IUUC-Cja-019081	Callithrix jacchus	91.62	0.00e+00	1551.00
IUUC-Cfa-020736	Canis familiaris	89.88	0.00e+00	1470.00
IUUC-Cpo-021581	Cavia porcellus	91.37	0.00e+00	1548.00
IUUC-Csa-024189	Chlorocebus sabaeus	89.56	0.00e+00	864.00
IUUC-Cho-024751	Choloepus hoffmanni	91.62	0.00e+00	1494.00
IUUC-Cin-025773	Ciona intestinalis	42.56	2.00e-148	518.00
IUUC-Csv-026090	Ciona savignyi	40.44	8.00e-173	600.00
IUUC-Dre-027788	Danio rerio	79.19	0.00e+00	1399.00
IUUC-Dno-030022	Dasypus novemcinctus	91.37	0.00e+00	1549.00
IUUC-Dme-031577	Drosophila melanogaster	47.54	0.00e+00	724.00
IUUC-Ete-032402	Echinops telfairi	89.74	0.00e+00	1473.00
IUUC-Eca-033908	Equus caballus	92.10	0.00e+00	1559.00
IUUC-Eeu-034869	Erinaceus europaeus	93.52	0.00e+00	889.00
IUUC-Fca-036023	Felis catus	92.47	0.00e+00	1561.00
IUUC-Gmo-039197	Gadus morhua	80.68	0.00e+00	1375.00
IUUC-Gga-040704	Gallus gallus	97.26	0.00e+00	1621.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.22	0.00e+00	1379.00
IUUC-Ggo-044527	Gorilla gorilla	88.35	0.00e+00	1483.00
IUUC-Hsa-046082	Homo sapiens	91.62	0.00e+00	1554.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	92.35	0.00e+00	1561.00
IUUC-Lch-049772	Latimeria chalumnae	77.15	0.00e+00	1257.00
IUUC-Loc-052541	Lepisosteus oculatus	81.26	0.00e+00	1420.00
IUUC-Laf-053852	Loxodonta africana	91.37	0.00e+00	1544.00
IUUC-Mcc-054759	Macaca mulatta	89.61	0.00e+00	780.00
IUUC-Meu-056247	Macropus eugenii	76.34	0.00e+00	821.00
IUUC-Mga-060161	Meleagris gallopavo	95.87	0.00e+00	1567.00
IUUC-Mmr-061447	Microcebus murinus	91.98	0.00e+00	1556.00
IUUC-Mdo-062110	Monodelphis domestica	91.62	0.00e+00	1494.00
IUUC-Mmu-064349	Mus musculus	91.13	0.00e+00	1548.00
IUUC-Mpu-065824	Mustela putorius furo	92.22	0.00e+00	1551.00
IUUC-Mlu-067729	Myotis lucifugus	91.86	0.00e+00	1524.00
IUUC-Nle-069721	Nomascus leucogenys	91.49	0.00e+00	1543.00
IUUC-Opr-070189	Ochotona princeps	91.80	0.00e+00	1545.00
IUUC-Ont-072122	Oreochromis niloticus	80.44	0.00e+00	1368.00
IUUC-Oan-072700	Ornithorhynchus anatinus	83.09	0.00e+00	1206.00
IUUC-Ocu-074057	Oryctolagus cuniculus	91.86	0.00e+00	1556.00
IUUC-Ola-087492	Oryzias latipes	79.37	0.00e+00	1380.00
IUUC-Oga-088084	Otolemur garnettii	91.98	0.00e+00	1550.00
IUUC-Oar-090354	Ovis aries	91.15	0.00e+00	1526.00
IUUC-Ptr-091456	Pan troglodytes	91.62	0.00e+00	1552.00
IUUC-Pan-092596	Papio anubis	90.41	0.00e+00	1526.00
IUUC-Psi-092942	Pelodiscus sinensis	94.90	0.00e+00	1562.00
IUUC-Pma-094662	Petromyzon marinus	63.21	0.00e+00	769.00
IUUC-Pfo-096838	Poecilia formosa	79.90	0.00e+00	1363.00
IUUC-Pab-097849	Pongo abelii	91.13	0.00e+00	1546.00
IUUC-Pca-100498	Procavia capensis	89.98	0.00e+00	889.00
IUUC-Pva-102599	Pteropus vampyrus	92.22	0.00e+00	1541.00
IUUC-Rno-105776	Rattus norvegicus	91.62	0.00e+00	1548.00
IUUC-Sha-106699	Sarcophilus harrisii	91.37	0.00e+00	1496.00
IUUC-Sar-113621	Sorex araneus	90.28	0.00e+00	1499.00
IUUC-Ssc-115742	Sus scrofa	91.62	0.00e+00	1553.00
IUUC-Tgu-116490	Taeniopygia guttata	98.91	0.00e+00	1628.00
IUUC-Tru-117679	Takifugu rubripes	80.07	0.00e+00	1364.00
IUUC-Tsy-119607	Tarsius syrichta	88.28	0.00e+00	1071.00
IUUC-Tni-120376	Tetraodon nigroviridis	76.33	0.00e+00	1280.00
IUUC-Tbe-127348	Tupaia belangeri	63.30	4.00e-173	600.00
IUUC-Ttr-128786	Tursiops truncatus	88.34	0.00e+00	1485.00
IUUC-Vpa-130180	Vicugna pacos	90.53	0.00e+00	1224.00
IUUC-Xtr-132631	Xenopus tropicalis	68.24	0.00e+00	1145.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence