iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060161

UUCD1 version

UUC-MeG-00578

Ensembl Protein ID

ENSMGAP00000013384.1

UniProt Accession

G1NJ92; G1NJ92_MELGA

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000012699.1	ENSMGAT00000014290.1	ENSMGAP00000013384.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.40e-102	340.9	486	823

Active Site

Position(s)	Description	Evidence
791	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++s+n+++ ++pnp + +    +lkl+ef+Grl+gk+l+++     
   Q: 486  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFtRFSDNNQALVHPNPGRPT--YVRLKLYEFAGRLVGKCLYESslgga 572
           7999**************************************788999**********986..48******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ ++  +  k++eL++gG+++pVtneNk 
   Q: 573  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DVSEMDLVFAEEKYSRTGQLEKVVELVTGGAQVPVTNENKI 658
           99***********************************99****99...9**************9************************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 659  FYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 747
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    ++  lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 748  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHGTLPTAHTCFNQLCLPTYDSYEEMHKMLQLAISEGcEGFGM 823
           ************************99555555.**************************************9***97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MFYIIGGITV SVVAFFFTIK FLFELAARIV SFLQHEDRER RGERTIYDYV RGNYLDPRSC 60
KVSWDWKEPH EVGHSMAFRV HDFERRNGQS FPAHRPLGLR VHICHVELAI DIPVTQEVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACA TTATTGGTAA GTGAAGGAAA GGCTGCCACT GTGTTTGTTG ACCTCTCCGT 60
AGGCATTAGA GGAACTTACT GAAAGCCTTT GATTTCATGT TAGAGTCTAC CTAACAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	91.25	0.00e+00	1544.00
IUUC-Apl-004071	Anas platyrhynchos	97.57	0.00e+00	1548.00
IUUC-Aca-005218	Anolis carolinensis	93.45	0.00e+00	1519.00
IUUC-Ame-011871	Astyanax mexicanus	79.00	0.00e+00	1379.00
IUUC-Bta-012978	Bos taurus	90.66	0.00e+00	1535.00
IUUC-Cja-019081	Callithrix jacchus	90.53	0.00e+00	1536.00
IUUC-Cfa-020736	Canis familiaris	89.65	0.00e+00	1469.00
IUUC-Cpo-021581	Cavia porcellus	90.53	0.00e+00	1535.00
IUUC-Csa-024189	Chlorocebus sabaeus	88.12	0.00e+00	847.00
IUUC-Cho-024751	Choloepus hoffmanni	90.53	0.00e+00	1471.00
IUUC-Cin-025773	Ciona intestinalis	43.16	8.00e-150	523.00
IUUC-Csv-026090	Ciona savignyi	40.84	4.00e-171	594.00
IUUC-Dre-027788	Danio rerio	79.13	0.00e+00	1376.00
IUUC-Dno-030022	Dasypus novemcinctus	90.29	0.00e+00	1531.00
IUUC-Dme-031577	Drosophila melanogaster	47.49	0.00e+00	718.00
IUUC-Ete-032402	Echinops telfairi	88.66	0.00e+00	1457.00
IUUC-Eca-033908	Equus caballus	91.26	0.00e+00	1545.00
IUUC-Eeu-034869	Erinaceus europaeus	93.74	0.00e+00	891.00
IUUC-Fca-036023	Felis catus	91.50	0.00e+00	1546.00
IUUC-Fal-037477	Ficedula albicollis	95.87	0.00e+00	1581.00
IUUC-Gmo-039197	Gadus morhua	79.25	0.00e+00	1357.00
IUUC-Gga-040704	Gallus gallus	98.67	0.00e+00	1606.00
IUUC-Gac-041511	Gasterosteus aculeatus	78.16	0.00e+00	1364.00
IUUC-Ggo-044527	Gorilla gorilla	87.27	0.00e+00	1464.00
IUUC-Hsa-046082	Homo sapiens	90.53	0.00e+00	1537.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	91.26	0.00e+00	1545.00
IUUC-Lch-049772	Latimeria chalumnae	76.33	0.00e+00	1238.00
IUUC-Loc-052541	Lepisosteus oculatus	81.36	0.00e+00	1396.00
IUUC-Laf-053852	Loxodonta africana	90.29	0.00e+00	1527.00
IUUC-Mcc-054759	Macaca mulatta	88.02	0.00e+00	763.00
IUUC-Meu-056247	Macropus eugenii	75.38	0.00e+00	806.00
IUUC-Mmr-061447	Microcebus murinus	90.78	0.00e+00	1538.00
IUUC-Mdo-062110	Monodelphis domestica	90.17	0.00e+00	1477.00
IUUC-Mmu-064349	Mus musculus	90.41	0.00e+00	1538.00
IUUC-Mpu-065824	Mustela putorius furo	91.38	0.00e+00	1537.00
IUUC-Mlu-067729	Myotis lucifugus	91.14	0.00e+00	1512.00
IUUC-Nle-069721	Nomascus leucogenys	90.41	0.00e+00	1526.00
IUUC-Opr-070189	Ochotona princeps	91.20	0.00e+00	1533.00
IUUC-Ont-072122	Oreochromis niloticus	79.37	0.00e+00	1353.00
IUUC-Oan-072700	Ornithorhynchus anatinus	83.22	0.00e+00	1201.00
IUUC-Ocu-074057	Oryctolagus cuniculus	90.90	0.00e+00	1540.00
IUUC-Ola-087492	Oryzias latipes	78.64	0.00e+00	1367.00
IUUC-Oga-088084	Otolemur garnettii	90.78	0.00e+00	1533.00
IUUC-Oar-090354	Ovis aries	90.31	0.00e+00	1511.00
IUUC-Ptr-091456	Pan troglodytes	90.53	0.00e+00	1534.00
IUUC-Pan-092596	Papio anubis	89.33	0.00e+00	1508.00
IUUC-Psi-092942	Pelodiscus sinensis	93.69	0.00e+00	1544.00
IUUC-Pma-094662	Petromyzon marinus	63.21	0.00e+00	764.00
IUUC-Pfo-096838	Poecilia formosa	79.85	0.00e+00	1339.00
IUUC-Pab-097849	Pongo abelii	90.05	0.00e+00	1529.00
IUUC-Pca-100498	Procavia capensis	88.40	0.00e+00	870.00
IUUC-Pva-102599	Pteropus vampyrus	91.14	0.00e+00	1523.00
IUUC-Rno-105776	Rattus norvegicus	90.78	0.00e+00	1533.00
IUUC-Sha-106699	Sarcophilus harrisii	90.53	0.00e+00	1484.00
IUUC-Sar-113621	Sorex araneus	89.68	0.00e+00	1488.00
IUUC-Ssc-115742	Sus scrofa	90.78	0.00e+00	1539.00
IUUC-Tgu-116490	Taeniopygia guttata	95.63	0.00e+00	1581.00
IUUC-Tru-117679	Takifugu rubripes	79.13	0.00e+00	1351.00
IUUC-Tsy-119607	Tarsius syrichta	87.79	0.00e+00	1073.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.39	0.00e+00	1268.00
IUUC-Tbe-127348	Tupaia belangeri	63.30	3.00e-174	604.00
IUUC-Ttr-128786	Tursiops truncatus	87.50	0.00e+00	1469.00
IUUC-Vpa-130180	Vicugna pacos	89.79	0.00e+00	1211.00
IUUC-Xtr-132631	Xenopus tropicalis	68.77	0.00e+00	1144.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence