iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-22	76.9	231	269
UBD/Beta-Prp	2.10e-48	165.1	32	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvl 35
           gH++ ++++a      d  +vs++ D t+++W++ tg+ 
   Q: 231  GHSNYIYSMARnealGDQVVVSCGEDSTLRMWNVITGDE 269
           79999999977777666899*************999886 PP

UBD/Beta-Prp

   S: 20   pdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshd 115
           ++++ +++gsrd+++kvw+ +   +l+sl  ++h+++++ ++f +++ ++ t+s+D+ti+++  + + ++ tlkghe++v++ls   +  +l+sGs+d
   Q: 32   EGRQTILSGSRDKSTKVWKPHGNEYLESLtlQDHKNFISYICFLESERWICTASNDATICIYKQDGFVPLLTLKGHESTVCALSAGLEPRSLISGSWD 129
           56789********************887766********************************************************99********* PP
   S: 116  rtirvwdletgqclee.tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.fdsngkelvsgsldgtvklwdlqt 211
           +t+rvw +++   ++   l+gh+++v+ v++ ++++ +v+G++Dr +  W+   g+ lr l+g htd v+ +  +d   + l+s+++d  +++w+   
   Q: 130  KTARVWTISEAGDVSFvALEGHEAAVWAVATLKEQRKYVTGGADRNIYYWNA-KGEKLRLLKG-HTDCVRGVMgLDA--NTLLSCGNDAVLRFWNE-D 222
           ********9987776569********************************87.7888899998.******9986777..68**************6.9 PP
   S: 212  gecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhn.ssvisvavlsfgdnvlvlgsedskvniwk 293
           gecvr++ngh++ ++s++      d+ +vs+++D ++r+W++ +gd l++   h   sv+sv++  +++  +v+g +d+ v++++
   Q: 223  GECVREMNGHSNYIYSMARNeaLGDQVVVSCGEDSTLRMWNVITGDELGAPIIHPgISVWSVTC--LQNGDIVTGCSDGVVRVFS 305
           ******************9976789********************99998555444********..9999*************97 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEPSLDNYKL SCELLGHSMD VRAVAVGPPT PEGRQTILSG SRDKSTKVWK PHGNEYLESL 60
TLQDHKNFIS YICFLESERW ICTASNDATI CIYKQDGFVP LLTLKGHEST VCALSAGLEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCTCGTAA CGCTTCAAAT AGTTGCTCTT TGCAATTGCG TGTGCAATAC CACCATTGTG 60
CAATTTCCTC ACATTCAGAT CGTTTTTCAG AAAGCAACAG CAGTAGTCGC AATAATAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR020472--G-protein_beta_WD-40_rep
IPR033510--PLAA/Doa1/Lub1
IPR015155--PLAA_fam_Ub-bd_PFU
IPR013535--PUL_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS51394--PFU
PS51396--PUL
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF09070--PFU
PF08324--PUL
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043130--F:ubiquitin binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010992--P:ubiquitin homeostasis

KEGG

dme:Dmel_CG5105

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000146	Aegilops tauschii	28.42	3.00e-72	265.00
IUUC-Aml-002125	Ailuropoda melanoleuca	36.73	1.00e-129	456.00
IUUC-Atr-002554	Amborella trichopoda	29.33	4.00e-72	265.00
IUUC-Apl-004094	Anas platyrhynchos	35.63	2.00e-118	419.00
IUUC-Aca-004726	Anolis carolinensis	36.71	9.00e-127	446.00
IUUC-Aly-005961	Arabidopsis lyrata	29.58	5.00e-77	281.00
IUUC-Ath-006639	Arabidopsis thaliana	29.08	2.00e-76	279.00
IUUC-Ago-007772	Ashbya gossypii	29.22	1.00e-71	263.00
IUUC-Acl-008316	Aspergillus clavatus	33.09	4.00e-84	305.00
IUUC-Afl-008532	Aspergillus flavus	32.69	8.00e-87	314.00
IUUC-Afu-008950	Aspergillus fumigatus	33.66	6.00e-89	321.00
IUUC-Ani-009186	Aspergillus nidulans	33.59	1.00e-98	353.00
IUUC-Ang-009575	Aspergillus niger	31.03	2.00e-79	289.00
IUUC-Aor-010086	Aspergillus oryzae	32.69	8.00e-87	314.00
IUUC-Ate-010541	Aspergillus terreus	31.66	2.00e-82	299.00
IUUC-Ame-011633	Astyanax mexicanus	35.44	2.00e-119	422.00
IUUC-Bgr-012292	Blumeria graminis	30.64	8.00e-86	310.00
IUUC-Bta-013218	Bos taurus	36.36	6.00e-132	464.00
IUUC-Bci-013876	Botrytis cinerea	32.81	2.00e-84	306.00
IUUC-Bdi-014810	Brachypodium distachyon	29.49	6.00e-78	284.00
IUUC-Bol-016006	Brassica oleracea	29.51	2.00e-78	286.00
IUUC-Bra-017593	Brassica rapa	29.94	2.00e-78	286.00
IUUC-Cel-018703	Caenorhabditis elegans	27.26	3.00e-64	239.00
IUUC-Cja-019270	Callithrix jacchus	37.12	7.00e-134	470.00
IUUC-Cfa-021262	Canis familiaris	36.61	6.00e-130	457.00
IUUC-Cpo-021449	Cavia porcellus	35.10	9.00e-116	410.00
IUUC-Csa-024140	Chlorocebus sabaeus	37.38	8.00e-135	473.00
IUUC-Cho-024923	Choloepus hoffmanni	42.56	9.00e-49	187.00
IUUC-Cin-025373	Ciona intestinalis	32.64	7.00e-106	377.00
IUUC-Csv-026324	Ciona savignyi	32.70	3.00e-110	392.00
IUUC-Cgl-026711	Colletotrichum gloeosporioides	27.34	7.00e-70	257.00
IUUC-Cne-026998	Cryptococcus neoformans	29.95	2.00e-70	259.00
IUUC-Cme-027154	Cyanidioschyzon merolae	32.06	8.00e-54	204.00
IUUC-Dre-028674	Danio rerio	34.65	5.00e-119	421.00
IUUC-Dno-028966	Dasypus novemcinctus	37.55	1.00e-132	466.00
IUUC-Dor-030343	Dipodomys ordii	33.67	8.00e-66	244.00
IUUC-Dse-031385	Dothistroma septosporum	29.64	3.00e-74	272.00
IUUC-Ete-032506	Echinops telfairi	32.34	7.00e-62	231.00
IUUC-Eca-033547	Equus caballus	37.25	4.00e-133	468.00
IUUC-Eeu-034462	Erinaceus europaeus	43.39	6.00e-50	191.00
IUUC-Fca-035893	Felis catus	36.49	4.00e-131	461.00
IUUC-Fal-037235	Ficedula albicollis	36.16	4.00e-132	464.00
IUUC-Fox-037836	Fusarium oxysporum	31.47	4.00e-86	311.00
IUUC-Fso-038251	Fusarium solani	31.24	6.00e-81	294.00
IUUC-Gmo-038648	Gadus morhua	39.12	1.00e-122	432.00
IUUC-Ggr-039867	Gaeumannomyces graminis	28.47	1.00e-76	280.00
IUUC-Gga-040989	Gallus gallus	37.23	6.00e-126	444.00
IUUC-Gac-041344	Gasterosteus aculeatus	35.30	2.00e-109	389.00
IUUC-Gma-043067	Glycine max	28.63	1.00e-64	240.00
IUUC-Ggo-045009	Gorilla gorilla	38.27	7.00e-112	397.00
IUUC-Hsa-046807	Homo sapiens	36.88	3.00e-132	464.00
IUUC-Itr-048636	Ictidomys tridecemlineatus	37.48	1.00e-134	473.00
IUUC-Kpa-049134	Komagataella pastoris	29.95	1.00e-73	270.00
IUUC-Lch-049597	Latimeria chalumnae	41.51	6.00e-93	333.00
IUUC-Lpe-050821	Leersia perrieri	29.77	2.00e-73	269.00
IUUC-Loc-051849	Lepisosteus oculatus	37.08	6.00e-123	434.00
IUUC-Lma-053297	Leptosphaeria maculans	32.73	1.00e-88	320.00
IUUC-Laf-053495	Loxodonta africana	37.17	2.00e-129	455.00
IUUC-Meu-055983	Macropus eugenii	43.05	2.00e-44	173.00
IUUC-Mor-057006	Magnaporthe oryzae	28.59	8.00e-76	277.00
IUUC-Mpo-057465	Magnaporthe poae	27.85	7.00e-75	274.00
IUUC-Mtr-058374	Medicago truncatula	28.04	7.00e-74	271.00
IUUC-Mla-058895	Melampsora laricipopulina	36.83	4.00e-75	274.00
IUUC-Mvi-060297	Microbotryum violaceum	31.65	2.00e-89	323.00
IUUC-Mmr-060810	Microcebus murinus	34.44	8.00e-114	403.00
IUUC-Mdo-062671	Monodelphis domestica	36.95	3.00e-129	455.00
IUUC-Mmu-063536	Mus musculus	36.88	2.00e-130	458.00
IUUC-Mac-064902	Musa acuminata	30.01	3.00e-78	285.00
IUUC-Mpu-066085	Mustela putorius furo	36.99	2.00e-133	469.00
IUUC-Mlu-067907	Myotis lucifugus	40.30	1.00e-102	365.00
IUUC-Nfi-068457	Neosartorya fischeri	33.76	2.00e-79	289.00
IUUC-Ncr-068622	Neurospora crassa	30.15	4.00e-82	298.00
IUUC-Nle-069049	Nomascus leucogenys	36.22	6.00e-130	457.00
IUUC-Opr-071013	Ochotona princeps	45.70	8.00e-33	134.00
IUUC-Ont-071339	Oreochromis niloticus	36.82	5.00e-124	437.00
IUUC-Oan-073353	Ornithorhynchus anatinus	44.21	9.00e-45	172.00
IUUC-Ocu-074625	Oryctolagus cuniculus	37.28	5.00e-133	468.00
IUUC-Oba-075226	Oryza barthii	27.73	3.00e-63	235.00
IUUC-Obr-076875	Oryza brachyantha	30.92	1.00e-80	293.00
IUUC-Ogl-077057	Oryza glaberrima	30.40	3.00e-79	288.00
IUUC-Ogu-078156	Oryza glumaepatula	30.36	2.00e-79	290.00
IUUC-Oin-079373	Oryza indica	30.15	9.00e-78	284.00
IUUC-Olo-080849	Oryza longistaminata	29.44	5.00e-61	228.00
IUUC-Ome-081654	Oryza meridionalis	27.63	2.00e-63	236.00
IUUC-Oni-082221	Oryza nivara	28.13	5.00e-66	245.00
IUUC-Opu-084103	Oryza punctata	28.42	2.00e-65	243.00
IUUC-Oru-084751	Oryza rufipogon	29.12	4.00e-63	235.00
IUUC-Osa-085584	Oryza sativa	30.17	2.00e-78	286.00
IUUC-Ola-086974	Oryzias latipes	36.57	7.00e-123	434.00
IUUC-Oga-088052	Otolemur garnettii	35.04	3.00e-117	415.00
IUUC-Oar-089509	Ovis aries	36.30	4.00e-128	451.00
IUUC-Ptr-090911	Pan troglodytes	36.88	8.00e-132	463.00
IUUC-Pan-092141	Papio anubis	37.24	8.00e-132	463.00
IUUC-Psi-093543	Pelodiscus sinensis	37.01	7.00e-123	433.00
IUUC-Pno-094952	Phaeosphaeria nodorum	32.90	2.00e-91	329.00
IUUC-Ppa-095881	Physcomitrella patens	30.64	3.00e-81	295.00
IUUC-Pfo-096739	Poecilia formosa	36.32	4.00e-119	421.00
IUUC-Pab-098641	Pongo abelii	37.00	7.00e-133	467.00
IUUC-Pop-099493	Populus trichocarpa	30.40	5.00e-79	288.00
IUUC-Pca-100599	Procavia capensis	33.96	1.00e-104	372.00
IUUC-Ppe-101874	Prunus persica	29.26	1.00e-73	270.00
IUUC-Pva-103009	Pteropus vampyrus	36.08	1.00e-104	373.00
IUUC-Pgr-103260	Puccinia graminis	34.28	2.00e-99	355.00
IUUC-Ptt-103711	Puccinia triticina	32.98	1.00e-90	326.00
IUUC-Pte-104337	Pyrenophora teres	32.87	2.00e-83	302.00
IUUC-Pyt-104475	Pyrenophora triticirepentis	32.46	4.00e-82	298.00
IUUC-Rno-105273	Rattus norvegicus	37.41	1.00e-132	466.00
IUUC-Sce-106351	Saccharomyces cerevisiae	36.48	4.00e-69	255.00
IUUC-Sha-106758	Sarcophilus harrisii	36.81	1.00e-131	462.00
IUUC-Sja-107687	Schizosaccharomyces japonicus	29.95	6.00e-81	294.00
IUUC-Spo-108093	Schizosaccharomyces pombe	31.54	7.00e-89	320.00
IUUC-Ssl-108623	Sclerotinia sclerotiorum	37.65	3.00e-80	292.00
IUUC-Smo-109368	Selaginella moellendorffii	29.18	1.00e-78	287.00
IUUC-Sit-109699	Setaria italica	30.47	1.00e-80	293.00
IUUC-Sly-111063	Solanum lycopersicum	29.41	2.00e-69	256.00
IUUC-Sar-113199	Sorex araneus	41.49	2.00e-79	289.00
IUUC-Sbi-114745	Sorghum bicolor	30.35	2.00e-77	282.00
IUUC-Sre-115080	Sporisorium reilianum	31.30	8.00e-95	340.00
IUUC-Ssc-115666	Sus scrofa	36.42	4.00e-130	457.00
IUUC-Tgu-116877	Taeniopygia guttata	36.03	1.00e-131	462.00
IUUC-Tru-117580	Takifugu rubripes	35.67	2.00e-122	432.00
IUUC-Tsy-118946	Tarsius syrichta	37.70	4.00e-124	437.00
IUUC-Tni-119755	Tetraodon nigroviridis	35.61	4.00e-113	401.00
IUUC-Tca-120977	Theobroma cacao	28.36	3.00e-73	269.00
IUUC-Tre-122217	Trichoderma reesei	31.27	4.00e-86	311.00
IUUC-Tvi-122671	Trichoderma virens	31.74	6.00e-85	308.00
IUUC-Tae-125266	Triticum aestivum	29.48	1.00e-78	287.00
IUUC-Tur-126404	Triticum urartu	26.51	2.00e-17	83.60
IUUC-Tme-126971	Tuber melanosporum	33.73	2.00e-92	332.00
IUUC-Tbe-127858	Tupaia belangeri	28.85	5.00e-37	148.00
IUUC-Ttr-128173	Tursiops truncatus	36.11	1.00e-127	449.00
IUUC-Uma-129322	Ustilago maydis	32.32	4.00e-95	341.00
IUUC-Vda-129682	Verticillium dahliae	29.33	1.00e-77	283.00
IUUC-Vpa-130607	Vicugna pacos	36.22	2.00e-121	429.00
IUUC-Vvi-131153	Vitis vinifera	29.97	1.00e-78	286.00
IUUC-Xtr-132208	Xenopus tropicalis	36.98	2.00e-132	465.00
IUUC-Xma-133098	Xiphophorus maculatus	36.06	7.00e-119	420.00
IUUC-Yli-134646	Yarrowia lipolytica	36.09	1.00e-73	270.00
IUUC-Zma-135920	Zea mays	29.42	3.00e-70	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence