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Tag Content
UUCD2 ID IUUC-Bta-013433
UUCD1 version UUC-BoT-00621
Ensembl Protein ID ENSBTAP00000011616.3
UniProt Accession F1MYX8; F1MYX8_BOVIN
Genbank Protein ID ENSBTAP00000011616
Protein Name Breast cancer type 1 susceptibility protein homolog
Genbank Nucleotide ID DAAA02049201
Gene Name BRCA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000022520.4 ENSBTAT00000011616.3 ENSBTAP00000011616.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 8.50e-08 32.8 24 65
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 65
           ********99.**************9666...68899********7 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
Protein Sequence
(Fasta)
MDLSADHVEE VQNVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLKII HAFELDTGLQ FANSYNFSRK EDNSPEHLKE 120
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Protein Fasta Sequence


>IUUC-Bta-013433|E3,RING|Bos taurus
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Nucleotide Sequence
(Fasta)
ATGGATTTAT CTGCGGATCA TGTTGAAGAA GTACAAAATG TCCTCAATGC TATGCAGAAA 60
ATCTTAGAGT GTCCAATATG GTAAGTTGAA AATTTATTAA TTTGAGATTC TTCTTGAATA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013433|E3,RING|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4
PRINTS

PR00493--BRSTCANCERI
SMART

SM00292--BRCT
SM00184--RING
Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002388 Ailuropoda melanoleuca 73.39 0.00e+00 2613.00
IUUC-Apl-003252 Anas platyrhynchos 35.86 3.00e-127 450.00
IUUC-Aca-004526 Anolis carolinensis 55.20 4.00e-79 289.00
IUUC-Ame-011720 Astyanax mexicanus 50.74 1.00e-56 215.00
IUUC-Bgr-011969 Blumeria graminis 38.89 2.00e-08 53.90
IUUC-Cel-018208 Caenorhabditis elegans 32.61 6.00e-11 62.40
IUUC-Cja-019149 Callithrix jacchus 70.71 0.00e+00 2422.00
IUUC-Cfa-020322 Canis familiaris 71.89 0.00e+00 2465.00
IUUC-Cpo-021583 Cavia porcellus 44.90 0.00e+00 1248.00
IUUC-Cre-022597 Chlamydomonas reinhardtii 29.41 1.00e-08 54.70
IUUC-Csa-024227 Chlorocebus sabaeus 71.65 2.00e-141 496.00
IUUC-Cho-024530 Choloepus hoffmanni 64.34 0.00e+00 1112.00
IUUC-Cin-025364 Ciona intestinalis 44.16 4.00e-15 75.10
IUUC-Csv-026245 Ciona savignyi 39.74 2.00e-13 68.90
IUUC-Dno-029247 Dasypus novemcinctus 66.90 0.00e+00 1883.00
IUUC-Dme-032032 Drosophila melanogaster 54.35 7.00e-11 58.50
IUUC-Ete-032472 Echinops telfairi 52.77 0.00e+00 1558.00
IUUC-Eca-033446 Equus caballus 75.95 0.00e+00 2722.00
IUUC-Eeu-034858 Erinaceus europaeus 58.40 0.00e+00 904.00
IUUC-Fca-035991 Felis catus 73.77 0.00e+00 2615.00
IUUC-Fal-036803 Ficedula albicollis 65.07 2.00e-84 308.00
IUUC-Gmo-038782 Gadus morhua 47.40 7.00e-49 189.00
IUUC-Ggr-039833 Gaeumannomyces graminis 36.73 9.00e-08 51.60
IUUC-Gga-040969 Gallus gallus 62.73 2.00e-81 298.00
IUUC-Gac-042296 Gasterosteus aculeatus 45.02 4.00e-53 204.00
IUUC-Ggo-044740 Gorilla gorilla 69.36 0.00e+00 2337.00
IUUC-Hsa-046086 Homo sapiens 71.78 0.00e+00 2412.00
IUUC-Itr-048512 Ictidomys tridecemlineatus 68.43 0.00e+00 2447.00
IUUC-Lch-049789 Latimeria chalumnae 55.95 4.00e-77 284.00
IUUC-Loc-051952 Lepisosteus oculatus 56.82 7.00e-74 273.00
IUUC-Laf-053648 Loxodonta africana 69.72 0.00e+00 2329.00
IUUC-Mcc-055210 Macaca mulatta 70.01 0.00e+00 2440.00
IUUC-Meu-056342 Macropus eugenii 37.12 6.00e-118 419.00
IUUC-Mor-057034 Magnaporthe oryzae 38.78 2.00e-08 53.50
IUUC-Mga-060163 Meleagris gallopavo 57.25 1.00e-84 308.00
IUUC-Mmr-061402 Microcebus murinus 66.67 0.00e+00 783.00
IUUC-Mdo-062209 Monodelphis domestica 44.75 0.00e+00 1264.00
IUUC-Mmu-064003 Mus musculus 53.03 0.00e+00 1654.00
IUUC-Mpu-065825 Mustela putorius furo 76.78 0.00e+00 773.00
IUUC-Mlu-068176 Myotis lucifugus 69.59 0.00e+00 2286.00
IUUC-Nle-069178 Nomascus leucogenys 71.94 0.00e+00 2442.00
IUUC-Opr-070574 Ochotona princeps 58.26 0.00e+00 1854.00
IUUC-Ont-072380 Oreochromis niloticus 50.48 3.00e-60 228.00
IUUC-Oan-073243 Ornithorhynchus anatinus 77.38 1.00e-35 141.00
IUUC-Ocu-074424 Oryctolagus cuniculus 66.06 0.00e+00 2255.00
IUUC-Ola-086863 Oryzias latipes 48.34 2.00e-56 214.00
IUUC-Oar-089938 Ovis aries 94.16 0.00e+00 3536.00
IUUC-Ptr-090960 Pan troglodytes 72.05 0.00e+00 2428.00
IUUC-Pan-092609 Papio anubis 68.56 0.00e+00 2090.00
IUUC-Psi-093889 Pelodiscus sinensis 26.59 2.00e-41 164.00
IUUC-Pfo-096328 Poecilia formosa 53.05 6.00e-64 239.00
IUUC-Pab-097982 Pongo abelii 72.05 0.00e+00 2451.00
IUUC-Pca-100698 Procavia capensis 65.56 0.00e+00 694.00
IUUC-Pva-102631 Pteropus vampyrus 74.48 0.00e+00 1152.00
IUUC-Rno-105879 Rattus norvegicus 52.71 0.00e+00 1609.00
IUUC-Sha-106701 Sarcophilus harrisii 38.55 0.00e+00 651.00
IUUC-Spo-108335 Schizosaccharomyces pombe 33.71 1.00e-09 58.20
IUUC-Sit-110609 Setaria italica 32.45 9.00e-18 85.90
IUUC-Sar-113047 Sorex araneus 61.51 0.00e+00 1454.00
IUUC-Ssc-115846 Sus scrofa 76.40 0.00e+00 2744.00
IUUC-Tgu-116785 Taeniopygia guttata 65.07 3.00e-83 304.00
IUUC-Tru-117895 Takifugu rubripes 45.97 3.00e-54 207.00
IUUC-Tsy-118885 Tarsius syrichta 71.67 5.00e-168 585.00
IUUC-Tni-119654 Tetraodon nigroviridis 44.76 4.00e-51 197.00
IUUC-Tbe-127421 Tupaia belangeri 57.36 4.00e-141 496.00
IUUC-Ttr-128685 Tursiops truncatus 79.45 0.00e+00 2704.00
IUUC-Vpa-130216 Vicugna pacos 71.53 0.00e+00 865.00
IUUC-Xtr-132398 Xenopus tropicalis 38.32 3.00e-67 251.00
IUUC-Xma-133651 Xiphophorus maculatus 54.71 6.00e-50 193.00
Created Date 25-Jun-2017

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