iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011403

Ensembl Protein ID

ENSAMXP00000009064.1

UniProt Accession

W5KNA2; W5KNA2_ASTMX

Genbank Protein ID

ENSAMXP00000009064

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01107987

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000008820.1	ENSAMXT00000009064.1	ENSAMXP00000009064.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-83	279.9	287	648

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp.........................................ke 44
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                         + 
   Q: 287  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTNHpqgvrgvsagmlgsasalsalgkqqnngsgelvqpkeprcsSR 375
           7******************************9997444444444447778888889999999999999999999999988888888777 PP
   S: 45   pkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeek 133
           ++ +l+++l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el++          + +++    + ++k
   Q: 376  QQVSLCHELHTLFRVMWSGRWTLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQELES--------DGSRKRRIVIPITQRK 456
           788************************************************************33........2233334456678999 PP
   S: 134  kkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdcLesftkeeelegenkyycekckkk 214
             k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++ ++        +l+++L++ft++e leg   y c+ c++k
   Q: 457  LSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSLEKasacqrscTLTEMLAKFTETEALEGC-IYACNFCNRK 544
           99******************************************9998877799**********************95.5*******99 PP
   S: 215  qe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsG.s 289
           ++           a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++++c+s++ +  +   ++Y+L+avv+H+G +
   Q: 545  RRksshkplalseACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNMESYCCSDSHAALQrqAYTYDLSAVVMHHGkG 632
           9999999999999***********************997.8889********************8877655558999************ PP
   S: 290  lssGHYvayvknekgk 305
           ++sGHY+ay++n++g+
   Q: 633  FGSGHYTAYCYNTEGG 648
           ************7765 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MDRCKHVVRL RLGHDHSILN PQKWHCVDCN TTESVWACLK CSHVACGRYI EEHSLRHYQE 60
TQHPLAMEVR ELDVFCFACG DYVLNDNAEG DLKLLRGALS TVRTSGQRSL RSASCAGELS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAATGCGA GGAGGCCTAC GCTTTTGACC TCAAGTGGAT CAAGAGGTTC TTCATTCCCG 60
AAAGCTGTGA TGCTCCACAC ACCTCCAATG AAGCGTTTAT GAGACTGCTT TCAGAGTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-025051	Choloepus hoffmanni	74.09	3.00e-128	452.00
IUUC-Dre-027577	Danio rerio	76.50	0.00e+00	864.00
IUUC-Gmo-039249	Gadus morhua	86.71	9.00e-145	507.00
IUUC-Gac-042595	Gasterosteus aculeatus	71.58	0.00e+00	851.00
IUUC-Loc-051961	Lepisosteus oculatus	73.25	8.00e-178	617.00
IUUC-Ont-072103	Oreochromis niloticus	73.30	0.00e+00	882.00
IUUC-Ola-086413	Oryzias latipes	70.48	0.00e+00	673.00
IUUC-Pma-094155	Petromyzon marinus	59.72	3.00e-85	308.00
IUUC-Pfo-096413	Poecilia formosa	71.58	0.00e+00	875.00
IUUC-Tru-117585	Takifugu rubripes	71.92	0.00e+00	853.00
IUUC-Tni-120600	Tetraodon nigroviridis	70.76	0.00e+00	832.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence