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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045949
Ensembl Protein ID ENSP00000263805.4
UniProt Accession Q9H2Y7; B4DZ40; E9PE29; Q6NSD9; Q6PEK1; Q86T43; Q86T45; Q86T50; Q86T58; Q86TA9; Q96M37; Q9H7B8; ZN106_HUMAN
Genbank Protein ID AAG35666.1; AAL40184.1; BAB14976.1; BAB71475.1; BAG63952.1; AAH58023.1; AAH70244.1; CAD89926.1; CAD91134.1; CAD91142.1; CAD91147.1; CAD91149.1
Protein Name Zinc finger protein 106; Zinc finger protein 474
Genbank Nucleotide ID AF205632; AF209502; AK024726; AK057410; AK302735; AC012651; BC070244; AL832455; AL831983; AL833301; AL832014; AL832352
Gene Name ZNF106; SH3BP3; ZFP106; ZNF474
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000103994.16 ENST00000263805.8 ENSP00000263805.4
ENSG00000103994.16 ENST00000565380.5 ENSP00000455674.1
ENSG00000103994.16 ENST00000565500.5 ENSP00000456604.1
ENSG00000103994.16 ENST00000569648.5 ENSP00000456191.1
ENSG00000103994.16 ENST00000567772.2 ENSP00000475881.1
ENSG00000103994.16 ENST00000564754.5 ENSP00000456845.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-19 69.9 1569 1609
UBD/Beta-Prp 2.60e-43 150.0 1669 1803
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sdtl...lvsGsdDgtikvWDlrtgvll 36
           gHt++v+cl     s+     l +Gs D+ti+++++++  ++
   Q: 1569 GHTSKVNCLLVtqtSG-KnaaLYTGSSDHTIRCYNVKSRECV 1609
           8*******95587533.24579**************988876 PP
   

   UBD/Beta-Prp
   S: 21   dksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklv 110
            ++ll++gs+d ti v d+++g llr+l+gh++++ ++k  +d  +  +gs+D+ ++  ++ tg+ v+++kgh++ v+ +++    +++v
   Q: 1669 ARKLLVVGSYDCTISVRDARNGLLLRTLEGHSKTILCMKVVND--LVFSGSSDQSVHAHNIHTGELVRIYKGHNHAVTVVNILG--KVMV 1754
           5689***************************************..9*************************************9..**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvr 162
           ++  d+ +rv++l++   l+ +  gh+++++c+++h+  +++ +G++D+ ++
   Q: 1755 TACLDKFVRVYELQSHDRLQ-VYGGHKDMIMCMTIHK--SMIYTGCYDGSIQ 1803
           ********************.****************..**********997 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MPVGRIECPS SPSFPRDISH ECRVCGVTEV GLSAYAKHIS GQLHKDNVDA QEREDDGKGE 60
EEEEDYFDKE LIQLIKQRKE QSRQDEPSNS NQEINSDDRR PQWRREDRIP YQDRESYSQP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045949|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGCGGCT GTGGCGGGGC CCGGCGGGGA GCGGGTCCGG AGCAGGCTCC CGGACCCAAA 60
ACTGAAGGGG GCGTCTGAGG CGTCAGGGAG CTCCCTCGCC TGGCTCTCGG CGGCCTGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045949|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR013087--Znf_C2H2_type
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00028--ZINC_FINGER_C2H2_1
Pfam

PF00400--WD40
SMART

SM00320--WD40
SM00355--ZnF_C2H2
Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0046872--F:metal ion binding
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0008286--P:insulin receptor signaling pathway
KEGG hsa:64397
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001928 Ailuropoda melanoleuca 88.21 0.00e+00 3183.00
IUUC-Apl-003674 Anas platyrhynchos 57.05 0.00e+00 1715.00
IUUC-Aca-005018 Anolis carolinensis 53.91 0.00e+00 1647.00
IUUC-Ame-011431 Astyanax mexicanus 68.95 0.00e+00 684.00
IUUC-Bta-013436 Bos taurus 87.80 0.00e+00 3082.00
IUUC-Cfa-020278 Canis familiaris 87.36 0.00e+00 2626.00
IUUC-Cpo-022278 Cavia porcellus 80.21 0.00e+00 2799.00
IUUC-Csa-023115 Chlorocebus sabaeus 95.89 0.00e+00 2092.00
IUUC-Cho-024829 Choloepus hoffmanni 82.44 0.00e+00 2226.00
IUUC-Dre-028112 Danio rerio 65.18 0.00e+00 666.00
IUUC-Dno-029127 Dasypus novemcinctus 84.97 0.00e+00 2967.00
IUUC-Dor-030367 Dipodomys ordii 81.18 0.00e+00 1207.00
IUUC-Ete-032500 Echinops telfairi 73.41 0.00e+00 1278.00
IUUC-Eca-034319 Equus caballus 89.53 0.00e+00 3128.00
IUUC-Eeu-034754 Erinaceus europaeus 77.13 0.00e+00 2421.00
IUUC-Fca-036181 Felis catus 88.85 0.00e+00 3102.00
IUUC-Fal-036865 Ficedula albicollis 56.21 0.00e+00 1609.00
IUUC-Gmo-039227 Gadus morhua 64.00 3.00e-175 608.00
IUUC-Gga-041178 Gallus gallus 57.25 0.00e+00 1743.00
IUUC-Gac-042209 Gasterosteus aculeatus 58.07 7.00e-169 587.00
IUUC-Ggo-044636 Gorilla gorilla 97.65 0.00e+00 3513.00
IUUC-Itr-048628 Ictidomys tridecemlineatus 88.97 0.00e+00 3164.00
IUUC-Lch-049753 Latimeria chalumnae 50.10 0.00e+00 1439.00
IUUC-Loc-052333 Lepisosteus oculatus 69.14 0.00e+00 728.00
IUUC-Laf-053530 Loxodonta africana 83.61 0.00e+00 3010.00
IUUC-Mcc-054664 Macaca mulatta 97.24 0.00e+00 3445.00
IUUC-Meu-056609 Macropus eugenii 67.04 0.00e+00 1231.00
IUUC-Mga-059632 Meleagris gallopavo 57.41 0.00e+00 1706.00
IUUC-Mmr-060742 Microcebus murinus 89.38 0.00e+00 3172.00
IUUC-Mdo-061831 Monodelphis domestica 82.21 0.00e+00 1330.00
IUUC-Mmu-064055 Mus musculus 76.76 0.00e+00 2573.00
IUUC-Mpu-066458 Mustela putorius furo 92.26 0.00e+00 1579.00
IUUC-Mlu-067767 Myotis lucifugus 84.92 0.00e+00 2962.00
IUUC-Nle-069728 Nomascus leucogenys 97.93 0.00e+00 3506.00
IUUC-Opr-070914 Ochotona princeps 80.01 0.00e+00 2790.00
IUUC-Ont-072462 Oreochromis niloticus 56.96 3.00e-163 568.00
IUUC-Ocu-073827 Oryctolagus cuniculus 87.47 0.00e+00 2997.00
IUUC-Ola-087573 Oryzias latipes 68.23 1.00e-162 566.00
IUUC-Oga-088664 Otolemur garnettii 89.65 0.00e+00 1870.00
IUUC-Oar-090256 Ovis aries 84.68 0.00e+00 2389.00
IUUC-Ptr-090884 Pan troglodytes 97.59 0.00e+00 2986.00
IUUC-Pan-091779 Papio anubis 96.06 0.00e+00 2100.00
IUUC-Psi-093267 Pelodiscus sinensis 93.09 2.00e-165 574.00
IUUC-Pma-094414 Petromyzon marinus 43.84 3.00e-59 223.00
IUUC-Pfo-097009 Poecilia formosa 63.99 4.00e-159 556.00
IUUC-Pca-100820 Procavia capensis 78.92 0.00e+00 2215.00
IUUC-Pva-103044 Pteropus vampyrus 80.39 0.00e+00 1233.00
IUUC-Rno-105960 Rattus norvegicus 71.53 0.00e+00 2358.00
IUUC-Sar-113018 Sorex araneus 75.87 0.00e+00 1367.00
IUUC-Ssc-115278 Sus scrofa 88.18 0.00e+00 3118.00
IUUC-Tgu-117231 Taeniopygia guttata 55.44 0.00e+00 1637.00
IUUC-Tru-118472 Takifugu rubripes 55.34 4.00e-165 576.00
IUUC-Tsy-118877 Tarsius syrichta 85.89 0.00e+00 2108.00
IUUC-Tni-119881 Tetraodon nigroviridis 56.67 3.00e-177 616.00
IUUC-Tbe-127499 Tupaia belangeri 80.36 0.00e+00 1619.00
IUUC-Ttr-128962 Tursiops truncatus 88.74 0.00e+00 3092.00
IUUC-Vpa-130089 Vicugna pacos 82.42 0.00e+00 1354.00
IUUC-Xtr-132940 Xenopus tropicalis 59.30 0.00e+00 886.00
Created Date 25-Jun-2017

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