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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063088
Ensembl Protein ID ENSMUSP00000060025.8
UniProt Accession Q80TR8; Q3UXD5; Q6P1E2; Q8CDY3; VPRBP_MOUSE
Genbank Protein ID AAH65119.1; BAC65654.3; BAC26425.1; BAE22628.1
Protein Name Protein VPRBP; DDB1- and CUL4-associated factor 1; Serine/threonine-protein kinase VPRBP
Genbank Nucleotide ID BC065119; AK122372; AK029372; AK135721
Gene Name Vprbp; Dcaf1; Kiaa0800
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040325.16 ENSMUST00000159645.7 ENSMUSP00000123865.1
ENSMUSG00000040325.16 ENSMUST00000055009.14 ENSMUSP00000060025.8
ENSMUSG00000040325.16 ENSMUST00000161758.2 ENSMUSP00000125730.1
ENSMUSG00000040325.16 ENSMUST00000163657.1 ENSMUSP00000131135.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/DCX/DWD 98.21 0.00e+00 2679.00 IUUC-Hsa-046935
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex. The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition. Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors. Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2.
 Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex. The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition. Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors. Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2.
Protein Sequence
(Fasta)
MTTVVVHVDS KAELTTLLEQ WEKDHGSGQD MVPILTRMSE LIEKETEEYR KGDPDPFDDR 60
HPGRADPECM LGHLLRILFK NDDFMNALVN AYVMTSREPP LNTAACRLLL DIMPGLETAV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063088|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
GTTACACACC CGCGCGCGCT GAGTGCGCGC GCGACCAGTA CGTAGCCTGC GAGTGACGCA 60
TAATATGTGG GCCGCTCAGG AGCCGTGGTC GCGCTGTGTG TGTGTATATG TGTGTGTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063088|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR006594--LisH
IPR033270--VPRBP/DCAF1
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
SMART

SM00667--LisH
Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0001650--C:fibrillar center
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:1990244--F:histone kinase activity (H2A-T120 specific)
GO:0030183--P:B cell differentiation
GO:0035212--P:cell competition in a multicellular organism
GO:1990245--P:histone H2A-T120 phosphorylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
GO:0033151--P:V(D)J recombination
GO:0016032--P:viral process
KEGG mmu:321006
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000876 Aegilops tauschii 34.49 1.00e-62 236.00
IUUC-Aml-001487 Ailuropoda melanoleuca 98.13 0.00e+00 2720.00
IUUC-Apl-004137 Anas platyrhynchos 93.26 0.00e+00 2635.00
IUUC-Aca-004721 Anolis carolinensis 90.31 0.00e+00 2537.00
IUUC-Ath-007548 Arabidopsis thaliana 37.86 9.00e-66 246.00
IUUC-Ame-011378 Astyanax mexicanus 77.36 0.00e+00 2189.00
IUUC-Bta-012499 Bos taurus 97.63 0.00e+00 2701.00
IUUC-Bdi-014023 Brachypodium distachyon 34.24 9.00e-53 203.00
IUUC-Bra-017818 Brassica rapa 35.27 3.00e-61 231.00
IUUC-Cel-018657 Caenorhabditis elegans 33.26 0.00e+00 686.00
IUUC-Cja-019341 Callithrix jacchus 94.84 0.00e+00 2637.00
IUUC-Cfa-020745 Canis familiaris 97.70 0.00e+00 2704.00
IUUC-Cpo-021525 Cavia porcellus 98.27 0.00e+00 2599.00
IUUC-Csa-023213 Chlorocebus sabaeus 98.21 0.00e+00 2720.00
IUUC-Cin-025759 Ciona intestinalis 37.89 0.00e+00 865.00
IUUC-Dno-029592 Dasypus novemcinctus 97.70 0.00e+00 2704.00
IUUC-Dme-031706 Drosophila melanogaster 39.38 5.00e-173 602.00
IUUC-Ete-033014 Echinops telfairi 89.47 0.00e+00 2231.00
IUUC-Eca-034424 Equus caballus 98.06 0.00e+00 2709.00
IUUC-Eeu-034747 Erinaceus europaeus 95.02 0.00e+00 1839.00
IUUC-Fca-035608 Felis catus 98.06 0.00e+00 2724.00
IUUC-Fal-037661 Ficedula albicollis 92.89 0.00e+00 2659.00
IUUC-Gmo-039173 Gadus morhua 75.08 0.00e+00 1357.00
IUUC-Gga-040754 Gallus gallus 92.97 0.00e+00 2629.00
IUUC-Gac-042394 Gasterosteus aculeatus 73.50 0.00e+00 1343.00
IUUC-Gma-043360 Glycine max 37.53 4.00e-60 227.00
IUUC-Ggo-044876 Gorilla gorilla 96.05 0.00e+00 2648.00
IUUC-Hsa-046935 Homo sapiens 98.21 0.00e+00 2720.00
IUUC-Hvu-047505 Hordeum vulgare 34.49 5.00e-62 233.00
IUUC-Lch-050623 Latimeria chalumnae 82.61 0.00e+00 2348.00
IUUC-Lpe-051488 Leersia perrieri 35.52 6.00e-54 207.00
IUUC-Loc-052384 Lepisosteus oculatus 81.29 0.00e+00 2253.00
IUUC-Laf-053421 Loxodonta africana 97.71 0.00e+00 2701.00
IUUC-Mcc-055301 Macaca mulatta 98.27 0.00e+00 2588.00
IUUC-Meu-056281 Macropus eugenii 95.85 0.00e+00 1906.00
IUUC-Mtr-058027 Medicago truncatula 35.84 5.00e-68 254.00
IUUC-Mga-059987 Meleagris gallopavo 92.82 0.00e+00 2602.00
IUUC-Mmr-060718 Microcebus murinus 98.35 0.00e+00 2689.00
IUUC-Mdo-062744 Monodelphis domestica 94.97 0.00e+00 2642.00
IUUC-Mpu-066788 Mustela putorius furo 97.99 0.00e+00 2724.00
IUUC-Mlu-067568 Myotis lucifugus 97.56 0.00e+00 2661.00
IUUC-Nle-069773 Nomascus leucogenys 98.13 0.00e+00 2716.00
IUUC-Opr-070786 Ochotona princeps 87.32 0.00e+00 2315.00
IUUC-Ont-072210 Oreochromis niloticus 74.43 0.00e+00 2176.00
IUUC-Ocu-074945 Oryctolagus cuniculus 98.06 0.00e+00 2711.00
IUUC-Olo-080575 Oryza longistaminata 26.98 6.00e-27 117.00
IUUC-Ome-081217 Oryza meridionalis 35.13 5.00e-54 207.00
IUUC-Opu-083522 Oryza punctata 35.31 5.00e-53 205.00
IUUC-Ola-087313 Oryzias latipes 75.59 0.00e+00 2160.00
IUUC-Olu-087714 Ostreococcus lucimarinus 32.67 3.00e-53 204.00
IUUC-Oga-088943 Otolemur garnettii 93.34 0.00e+00 2512.00
IUUC-Oar-089356 Ovis aries 97.54 0.00e+00 2726.00
IUUC-Psi-093315 Pelodiscus sinensis 93.32 0.00e+00 2601.00
IUUC-Ppa-095994 Physcomitrella patens 37.11 2.00e-61 231.00
IUUC-Pfo-097433 Poecilia formosa 75.47 0.00e+00 2093.00
IUUC-Pab-098284 Pongo abelii 93.63 0.00e+00 2560.00
IUUC-Pop-099939 Populus trichocarpa 35.06 5.00e-54 207.00
IUUC-Pca-100616 Procavia capensis 88.50 0.00e+00 2276.00
IUUC-Ppe-102063 Prunus persica 37.38 3.00e-58 221.00
IUUC-Rno-104955 Rattus norvegicus 99.56 0.00e+00 2650.00
IUUC-Sha-107589 Sarcophilus harrisii 95.27 0.00e+00 2657.00
IUUC-Sar-112949 Sorex araneus 91.53 0.00e+00 2455.00
IUUC-Ssc-116123 Sus scrofa 98.25 0.00e+00 2502.00
IUUC-Tgu-117468 Taeniopygia guttata 90.23 0.00e+00 2584.00
IUUC-Tru-117804 Takifugu rubripes 76.45 0.00e+00 2110.00
IUUC-Tsy-118801 Tarsius syrichta 86.36 0.00e+00 2322.00
IUUC-Tni-120578 Tetraodon nigroviridis 76.37 0.00e+00 2085.00
IUUC-Tur-126857 Triticum urartu 34.49 8.00e-63 236.00
IUUC-Tbe-128066 Tupaia belangeri 87.11 0.00e+00 1764.00
IUUC-Ttr-128293 Tursiops truncatus 93.11 0.00e+00 2492.00
IUUC-Vpa-130272 Vicugna pacos 77.47 0.00e+00 889.00
IUUC-Vvi-131322 Vitis vinifera 36.41 6.00e-56 214.00
IUUC-Xtr-132357 Xenopus tropicalis 83.21 0.00e+00 2279.00
Created Date 25-Jun-2017

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