iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134327

Ensembl Protein ID

CAG79047

UniProt Accession

Q6C794; ATG8_YARLI

Genbank Protein ID

CAG79047.2

Protein Name

Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8

Genbank Nucleotide ID

CR382131

Gene Name

ATG8; YALI0E02662g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E02662g	CAG79047	CAG79047

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	4.10e-48	160.3	13	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgflyvayasee 101
           kr++e+e+ir+k++d++Pvi+ek +k++ip++dkkkylvP+dltvgq+v++irkr++l +e a+f++v+++l++++a +++iyee+kdedgflyv+y++e+
   Q: 13   KRRAEAERIRKKYDDRVPVICEKVEKSDIPVIDKKKYLVPADLTVGQFVYVIRKRIKLSSERAIFIFVDDVLPPTAALMSSIYEEHKDEDGFLYVTYSGEN 113
           699************************************************************************************************** PP
   S: 102  tfG 104
           tfG
   Q: 114  TFG 116
           **9 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.

Protein Sequence
(Fasta)

MRSKFKDEHP FEKRRAEAER IRKKYDDRVP VICEKVEKSD IPVIDKKKYL VPADLTVGQF 60
VYVIRKRIKL SSERAIFIFV DDVLPPTAAL MSSIYEEHKD EDGFLYVTYS GENTFGDLEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGAGTATC GAGGGACATG GAATGATGGC CCGTGGCGTC CGACGGTGAC GGCTACTCTA 60
ACCTGTCAAT TGTTGAGGCC GTCTGGGCTT GCCTCCGCTT GTGCCTGATG GCCAGATGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

yli:YALI0E02662g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	75.65	1.00e-50	189.00
IUUC-Aml-001629	Ailuropoda melanoleuca	60.34	1.00e-38	149.00
IUUC-Atr-002791	Amborella trichopoda	81.20	1.00e-53	199.00
IUUC-Apl-003994	Anas platyrhynchos	56.90	2.00e-37	145.00
IUUC-Aca-005288	Anolis carolinensis	60.34	9.00e-39	149.00
IUUC-Aly-005554	Arabidopsis lyrata	83.48	5.00e-46	173.00
IUUC-Ath-006958	Arabidopsis thaliana	82.61	2.00e-45	171.00
IUUC-Ago-007898	Ashbya gossypii	72.88	3.00e-50	187.00
IUUC-Acl-008314	Aspergillus clavatus	90.68	2.00e-60	221.00
IUUC-Afl-008708	Aspergillus flavus	91.53	5.00e-61	223.00
IUUC-Afu-009097	Aspergillus fumigatus	90.68	2.00e-60	221.00
IUUC-Ani-009196	Aspergillus nidulans	90.68	3.00e-60	221.00
IUUC-Ang-009530	Aspergillus niger	90.68	2.00e-60	221.00
IUUC-Aor-009909	Aspergillus oryzae	91.53	5.00e-61	223.00
IUUC-Ate-010358	Aspergillus terreus	90.68	2.00e-60	221.00
IUUC-Ame-010751	Astyanax mexicanus	60.34	8.00e-39	149.00
IUUC-Bgr-012248	Blumeria graminis	88.98	4.00e-59	217.00
IUUC-Bta-012520	Bos taurus	60.34	2.00e-38	148.00
IUUC-Bci-013959	Botrytis cinerea	88.89	7.00e-60	219.00
IUUC-Bdi-014390	Brachypodium distachyon	81.20	5.00e-53	197.00
IUUC-Bol-016488	Brassica oleracea	82.61	2.00e-53	198.00
IUUC-Bra-017452	Brassica rapa	81.74	2.00e-52	195.00
IUUC-Cel-018200	Caenorhabditis elegans	55.17	1.00e-35	139.00
IUUC-Cja-019273	Callithrix jacchus	59.48	2.00e-38	148.00
IUUC-Cfa-020373	Canis familiaris	60.34	1.00e-38	149.00
IUUC-Cpo-021831	Cavia porcellus	60.34	1.00e-38	149.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	78.99	4.00e-46	174.00
IUUC-Csa-024201	Chlorocebus sabaeus	60.34	1.00e-38	149.00
IUUC-Cho-025008	Choloepus hoffmanni	53.45	7.00e-35	136.00
IUUC-Cin-025297	Ciona intestinalis	58.62	2.00e-38	148.00
IUUC-Csv-026146	Ciona savignyi	39.32	8.00e-23	97.10
IUUC-Cgl-026691	Colletotrichum gloeosporioides	65.64	5.00e-54	201.00
IUUC-Cne-026889	Cryptococcus neoformans	85.37	1.00e-60	222.00
IUUC-Dre-028371	Danio rerio	59.48	5.00e-38	147.00
IUUC-Dno-029331	Dasypus novemcinctus	60.34	1.00e-38	149.00
IUUC-Dor-030453	Dipodomys ordii	60.34	1.00e-38	149.00
IUUC-Dse-031428	Dothistroma septosporum	90.60	4.00e-60	220.00
IUUC-Dme-031813	Drosophila melanogaster	61.21	8.00e-40	153.00
IUUC-Ete-032671	Echinops telfairi	61.21	7.00e-40	153.00
IUUC-Eca-034113	Equus caballus	60.34	2.00e-38	149.00
IUUC-Eeu-035131	Erinaceus europaeus	56.98	3.00e-26	107.00
IUUC-Fca-036385	Felis catus	60.34	1.00e-38	149.00
IUUC-Fal-036896	Ficedula albicollis	60.34	2.00e-38	149.00
IUUC-Fox-037846	Fusarium oxysporum	91.45	9.00e-61	222.00
IUUC-Fso-038134	Fusarium solani	91.45	1.00e-60	222.00
IUUC-Gmo-039289	Gadus morhua	59.48	3.00e-38	147.00
IUUC-Ggr-039770	Gaeumannomyces graminis	88.98	2.00e-59	218.00
IUUC-Gga-040257	Gallus gallus	60.34	8.00e-39	149.00
IUUC-Gac-041604	Gasterosteus aculeatus	61.21	9.00e-40	153.00
IUUC-Gma-043726	Glycine max	80.83	3.00e-46	174.00
IUUC-Ggo-044429	Gorilla gorilla	60.34	1.00e-38	149.00
IUUC-Hsa-046764	Homo sapiens	60.34	1.00e-38	149.00
IUUC-Hvu-047588	Hordeum vulgare	78.99	3.00e-53	197.00
IUUC-Itr-048405	Ictidomys tridecemlineatus	61.21	9.00e-40	152.00
IUUC-Kpa-049124	Komagataella pastoris	83.05	2.00e-56	208.00
IUUC-Lch-049542	Latimeria chalumnae	59.48	1.00e-38	149.00
IUUC-Lpe-051292	Leersia perrieri	80.87	4.00e-52	194.00
IUUC-Loc-052290	Lepisosteus oculatus	61.21	7.00e-40	154.00
IUUC-Laf-054203	Loxodonta africana	61.21	9.00e-40	152.00
IUUC-Mcc-055307	Macaca mulatta	61.21	9.00e-40	152.00
IUUC-Meu-056515	Macropus eugenii	60.34	1.00e-38	149.00
IUUC-Mor-057276	Magnaporthe oryzae	89.83	1.00e-59	219.00
IUUC-Mpo-057469	Magnaporthe poae	88.98	6.00e-59	216.00
IUUC-Mtr-058417	Medicago truncatula	82.05	8.00e-46	173.00
IUUC-Mla-059098	Melampsora laricipopulina	87.07	2.00e-58	215.00
IUUC-Mga-060108	Meleagris gallopavo	55.93	1.00e-37	146.00
IUUC-Mvi-060496	Microbotryum violaceum	87.83	3.00e-57	211.00
IUUC-Mmr-061776	Microcebus murinus	61.21	9.00e-40	152.00
IUUC-Mdo-061915	Monodelphis domestica	60.34	1.00e-38	149.00
IUUC-Mmu-064152	Mus musculus	60.34	1.00e-38	149.00
IUUC-Mac-064739	Musa acuminata	77.78	8.00e-46	172.00
IUUC-Mpu-066760	Mustela putorius furo	60.34	1.00e-38	149.00
IUUC-Mlu-068211	Myotis lucifugus	60.34	1.00e-38	149.00
IUUC-Nfi-068367	Neosartorya fischeri	90.68	2.00e-60	221.00
IUUC-Ncr-068894	Neurospora crassa	90.76	3.00e-61	224.00
IUUC-Nle-069755	Nomascus leucogenys	60.34	1.00e-38	149.00
IUUC-Opr-070777	Ochotona princeps	61.21	1.00e-39	152.00
IUUC-Ont-072343	Oreochromis niloticus	60.34	1.00e-38	149.00
IUUC-Oan-073485	Ornithorhynchus anatinus	62.86	1.00e-35	139.00
IUUC-Ocu-073861	Oryctolagus cuniculus	60.34	1.00e-38	149.00
IUUC-Oba-075926	Oryza barthii	80.87	2.00e-52	195.00
IUUC-Obr-076374	Oryza brachyantha	80.87	2.00e-52	195.00
IUUC-Ogl-077457	Oryza glaberrima	80.87	2.00e-52	195.00
IUUC-Ogu-078078	Oryza glumaepatula	80.87	2.00e-52	195.00
IUUC-Oin-079771	Oryza indica	80.87	2.00e-52	195.00
IUUC-Olo-080412	Oryza longistaminata	80.87	2.00e-52	195.00
IUUC-Ome-081791	Oryza meridionalis	80.87	2.00e-52	195.00
IUUC-Oni-082774	Oryza nivara	80.87	2.00e-52	195.00
IUUC-Opu-083486	Oryza punctata	80.87	6.00e-52	195.00
IUUC-Oru-084197	Oryza rufipogon	75.65	9.00e-51	189.00
IUUC-Osa-085439	Oryza sativa	80.87	2.00e-52	195.00
IUUC-Ola-086310	Oryzias latipes	59.48	5.00e-38	147.00
IUUC-Olu-087892	Ostreococcus lucimarinus	82.14	2.00e-53	198.00
IUUC-Oga-088483	Otolemur garnettii	60.34	1.00e-38	149.00
IUUC-Oar-089989	Ovis aries	61.21	9.00e-40	152.00
IUUC-Ptr-091560	Pan troglodytes	60.34	1.00e-38	149.00
IUUC-Pan-092269	Papio anubis	60.34	1.00e-38	149.00
IUUC-Psi-093055	Pelodiscus sinensis	56.90	2.00e-37	145.00
IUUC-Pma-094337	Petromyzon marinus	60.34	2.00e-40	155.00
IUUC-Pno-095035	Phaeosphaeria nodorum	90.60	2.00e-60	221.00
IUUC-Ppa-095786	Physcomitrella patens	83.48	2.00e-53	198.00
IUUC-Pfo-096380	Poecilia formosa	59.48	2.00e-38	148.00
IUUC-Pab-098563	Pongo abelii	60.34	1.00e-38	149.00
IUUC-Pop-100069	Populus trichocarpa	82.61	1.00e-45	172.00
IUUC-Pca-100230	Procavia capensis	61.21	9.00e-40	152.00
IUUC-Ppe-101670	Prunus persica	79.13	3.00e-46	174.00
IUUC-Pva-103103	Pteropus vampyrus	56.90	2.00e-37	145.00
IUUC-Pte-104230	Pyrenophora teres	90.60	2.00e-60	221.00
IUUC-Rno-105111	Rattus norvegicus	60.34	1.00e-38	149.00
IUUC-Sce-106150	Saccharomyces cerevisiae	78.45	3.00e-52	194.00
IUUC-Sha-106656	Sarcophilus harrisii	61.21	9.00e-40	152.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	81.90	3.00e-54	201.00
IUUC-Spo-108156	Schizosaccharomyces pombe	78.81	2.00e-46	175.00
IUUC-Ssl-108578	Sclerotinia sclerotiorum	88.89	1.00e-59	219.00
IUUC-Smo-109082	Selaginella moellendorffii	80.00	2.00e-52	195.00
IUUC-Sit-109732	Setaria italica	80.00	6.00e-52	193.00
IUUC-Sly-111488	Solanum lycopersicum	78.63	6.00e-47	176.00
IUUC-Stu-112612	Solanum tuberosum	82.20	3.00e-54	201.00
IUUC-Sar-113670	Sorex araneus	56.03	3.00e-35	138.00
IUUC-Sbi-114346	Sorghum bicolor	80.87	2.00e-52	195.00
IUUC-Sre-114964	Sporisorium reilianum	82.76	2.00e-55	204.00
IUUC-Ssc-115828	Sus scrofa	60.34	1.00e-38	149.00
IUUC-Tgu-117195	Taeniopygia guttata	60.34	1.00e-38	149.00
IUUC-Tru-118632	Takifugu rubripes	59.17	6.00e-40	154.00
IUUC-Tsy-118919	Tarsius syrichta	56.90	2.00e-37	145.00
IUUC-Tni-120706	Tetraodon nigroviridis	59.48	5.00e-38	147.00
IUUC-Tca-121837	Theobroma cacao	83.48	3.00e-45	171.00
IUUC-Tre-122077	Trichoderma reesei	91.38	4.00e-60	220.00
IUUC-Tvi-122400	Trichoderma virens	91.38	4.00e-60	220.00
IUUC-Tae-124455	Triticum aestivum	79.49	3.00e-52	194.00
IUUC-Tur-126158	Triticum urartu	74.78	9.00e-50	186.00
IUUC-Tme-126955	Tuber melanosporum	90.52	1.00e-58	216.00
IUUC-Tbe-127765	Tupaia belangeri	63.95	1.00e-29	118.00
IUUC-Ttr-128205	Tursiops truncatus	60.34	1.00e-38	149.00
IUUC-Uma-129435	Ustilago maydis	82.20	7.00e-56	206.00
IUUC-Vda-129807	Verticillium dahliae	90.76	3.00e-61	224.00
IUUC-Vpa-130804	Vicugna pacos	59.48	3.00e-38	147.00
IUUC-Vvi-130830	Vitis vinifera	80.34	8.00e-47	176.00
IUUC-Xtr-132685	Xenopus tropicalis	60.34	8.00e-39	150.00
IUUC-Xma-133675	Xiphophorus maculatus	59.48	2.00e-38	148.00
IUUC-Zma-135270	Zea mays	81.20	3.00e-53	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence