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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047021
UUCD1 version UUC-HoS-01257
Ensembl Protein ID ENSP00000263795.6
UniProt Accession Q9H967; A0MNP5; Q05CI4; WDR76_HUMAN
Genbank Protein ID ABK41114.1; BAB14369.1; BAF83622.1; AAH25247.1; AAH51855.1
Protein Name WD repeat-containing protein 76
Genbank Nucleotide ID EF011624; AK023035; AK290933; AC018512; BC051855
Gene Name WDR76
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000092470.11 ENST00000263795.10 ENSP00000263795.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-12 47.9 359 389
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWD 29
           H+ +v+cl f   +  +++s s+Dgt+++ D
   Q: 359  HSQPVSCLYFspaNPAHILSLSYDGTLRCGD 389
           9**********963399**********9855 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
 Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Protein Sequence
(Fasta)
MSRSGAAAEK ADSRQRPQMK VNEYKENQNI AYVSLRPAQT TVLIKTAKVY LAPFSLSNYQ 60
LDQLMCPKSL SEKNSNNEVA CKKTKIKKTC RRIIPPKMKN TSSKAESTLQ NSSSAVHTES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047021|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCGGACCCGC CCCTCCCGGC CTCCCGCCGC AATCTTGGCG GGAAGGCGCC GGCCGCTAAG 60
AAGCCGAAAG ATGTCCAGGT CGGGCGCGGC GGCTGAGAAG GCGGACTCCA GACAGCGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047021|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR033052--Cmr1/WDR76
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
SMART

SM00320--WD40
Gene Ontology

GO:0006974--P:cellular response to DNA damage stimulus
KEGG hsa:79968
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002605 Amborella trichopoda 26.90 6.00e-25 108.00
IUUC-Apl-003441 Anas platyrhynchos 53.32 1.00e-141 496.00
IUUC-Aca-004241 Anolis carolinensis 57.76 6.00e-150 523.00
IUUC-Aly-005444 Arabidopsis lyrata 26.96 1.00e-27 118.00
IUUC-Ath-007550 Arabidopsis thaliana 26.57 6.00e-27 115.00
IUUC-Ago-007715 Ashbya gossypii 23.87 3.00e-15 76.60
IUUC-Acl-008370 Aspergillus clavatus 25.26 2.00e-31 130.00
IUUC-Afl-008586 Aspergillus flavus 27.32 9.00e-36 144.00
IUUC-Afu-008907 Aspergillus fumigatus 26.53 3.00e-33 136.00
IUUC-Ani-009415 Aspergillus nidulans 26.40 3.00e-30 126.00
IUUC-Ang-009597 Aspergillus niger 24.86 2.00e-11 64.30
IUUC-Aor-010197 Aspergillus oryzae 27.32 6.00e-36 145.00
IUUC-Ate-010280 Aspergillus terreus 25.99 3.00e-33 136.00
IUUC-Bgr-012236 Blumeria graminis 24.80 8.00e-24 105.00
IUUC-Bta-013059 Bos taurus 79.01 0.00e+00 945.00
IUUC-Bci-013796 Botrytis cinerea 26.72 4.00e-29 122.00
IUUC-Bdi-015040 Brachypodium distachyon 28.74 2.00e-20 93.60
IUUC-Bol-015202 Brassica oleracea 26.40 7.00e-24 105.00
IUUC-Bra-018032 Brassica rapa 25.62 3.00e-23 103.00
IUUC-Cja-019043 Callithrix jacchus 92.50 0.00e+00 1096.00
IUUC-Cfa-021103 Canis familiaris 81.05 0.00e+00 957.00
IUUC-Cpo-021508 Cavia porcellus 73.29 0.00e+00 885.00
IUUC-Cre-022967 Chlamydomonas reinhardtii 35.35 3.00e-10 60.50
IUUC-Csa-023555 Chlorocebus sabaeus 95.66 0.00e+00 976.00
IUUC-Cho-024931 Choloepus hoffmanni 64.39 2.00e-146 513.00
IUUC-Cin-025651 Ciona intestinalis 32.45 2.00e-61 230.00
IUUC-Cgl-026604 Colletotrichum gloeosporioides 24.10 1.00e-27 118.00
IUUC-Cne-027093 Cryptococcus neoformans 24.32 2.00e-19 90.50
IUUC-Cme-027238 Cyanidioschyzon merolae 27.39 2.00e-21 97.80
IUUC-Dre-027441 Danio rerio 35.83 1.00e-88 320.00
IUUC-Dno-029575 Dasypus novemcinctus 79.45 0.00e+00 957.00
IUUC-Dor-030554 Dipodomys ordii 73.36 0.00e+00 664.00
IUUC-Dse-031299 Dothistroma septosporum 26.26 3.00e-31 129.00
IUUC-Ete-032716 Echinops telfairi 62.80 0.00e+00 662.00
IUUC-Eca-034027 Equus caballus 80.92 0.00e+00 818.00
IUUC-Eeu-035234 Erinaceus europaeus 84.08 2.00e-79 290.00
IUUC-Fca-035892 Felis catus 81.62 0.00e+00 952.00
IUUC-Fal-036986 Ficedula albicollis 51.28 2.00e-124 439.00
IUUC-Fox-037750 Fusarium oxysporum 24.51 3.00e-27 116.00
IUUC-Fso-038198 Fusarium solani 23.64 2.00e-20 94.00
IUUC-Gga-040479 Gallus gallus 51.08 7.00e-104 370.00
IUUC-Gac-042043 Gasterosteus aculeatus 43.52 1.00e-93 337.00
IUUC-Gma-043913 Glycine max 26.48 7.00e-34 138.00
IUUC-Ggo-045290 Gorilla gorilla 98.56 0.00e+00 1189.00
IUUC-Hvu-047193 Hordeum vulgare 29.07 3.00e-17 82.80
IUUC-Itr-047914 Ictidomys tridecemlineatus 79.97 0.00e+00 968.00
IUUC-Kpa-049275 Komagataella pastoris 22.69 3.00e-19 90.10
IUUC-Lch-049718 Latimeria chalumnae 56.20 2.00e-150 526.00
IUUC-Lpe-051708 Leersia perrieri 27.57 4.00e-16 79.30
IUUC-Loc-052565 Lepisosteus oculatus 47.22 1.00e-115 410.00
IUUC-Lma-053276 Leptosphaeria maculans 26.10 1.00e-31 131.00
IUUC-Laf-053970 Loxodonta africana 76.39 0.00e+00 912.00
IUUC-Mcc-054740 Macaca mulatta 95.38 0.00e+00 999.00
IUUC-Meu-056546 Macropus eugenii 65.42 2.00e-75 276.00
IUUC-Mtr-058451 Medicago truncatula 25.95 4.00e-34 139.00
IUUC-Mla-059117 Melampsora laricipopulina 26.46 1.00e-23 104.00
IUUC-Mga-059328 Meleagris gallopavo 47.75 4.00e-105 375.00
IUUC-Mvi-060555 Microbotryum violaceum 26.98 5.00e-22 99.40
IUUC-Mmr-061520 Microcebus murinus 81.80 0.00e+00 1004.00
IUUC-Mdo-062812 Monodelphis domestica 60.36 0.00e+00 687.00
IUUC-Mmu-064011 Mus musculus 69.48 0.00e+00 700.00
IUUC-Mpu-066486 Mustela putorius furo 80.29 0.00e+00 948.00
IUUC-Mlu-067721 Myotis lucifugus 77.08 0.00e+00 767.00
IUUC-Nfi-068314 Neosartorya fischeri 26.91 6.00e-33 135.00
IUUC-Ncr-068896 Neurospora crassa 26.34 3.00e-28 120.00
IUUC-Nle-069369 Nomascus leucogenys 97.77 0.00e+00 1199.00
IUUC-Opr-070975 Ochotona princeps 75.29 0.00e+00 838.00
IUUC-Ont-072528 Oreochromis niloticus 42.32 2.00e-101 363.00
IUUC-Oan-072955 Ornithorhynchus anatinus 60.73 3.00e-145 508.00
IUUC-Ocu-074561 Oryctolagus cuniculus 80.81 0.00e+00 923.00
IUUC-Oba-074982 Oryza barthii 27.81 8.00e-22 99.00
IUUC-Ogl-077685 Oryza glaberrima 27.27 4.00e-22 99.40
IUUC-Ogu-078331 Oryza glumaepatula 27.27 4.00e-22 99.40
IUUC-Oin-079507 Oryza indica 27.41 1.00e-21 98.20
IUUC-Olo-080604 Oryza longistaminata 29.20 5.00e-17 82.40
IUUC-Ome-081816 Oryza meridionalis 26.16 2.00e-20 94.00
IUUC-Oni-082051 Oryza nivara 27.27 8.00e-22 98.60
IUUC-Opu-083372 Oryza punctata 26.92 7.00e-20 92.00
IUUC-Oru-084578 Oryza rufipogon 27.27 4.00e-22 99.40
IUUC-Osa-086177 Oryza sativa 27.27 4.00e-22 99.40
IUUC-Ola-087208 Oryzias latipes 42.61 2.00e-96 345.00
IUUC-Olu-087680 Ostreococcus lucimarinus 29.72 1.00e-33 137.00
IUUC-Oga-088104 Otolemur garnettii 82.04 0.00e+00 983.00
IUUC-Oar-090157 Ovis aries 80.32 0.00e+00 957.00
IUUC-Ptr-091615 Pan troglodytes 98.40 0.00e+00 1186.00
IUUC-Pan-092212 Papio anubis 96.65 0.00e+00 1097.00
IUUC-Psi-092950 Pelodiscus sinensis 52.91 2.00e-166 578.00
IUUC-Pma-094625 Petromyzon marinus 33.22 6.00e-31 127.00
IUUC-Pno-094824 Phaeosphaeria nodorum 27.05 5.00e-36 145.00
IUUC-Pfo-096922 Poecilia formosa 41.60 1.00e-104 374.00
IUUC-Pab-097591 Pongo abelii 98.41 0.00e+00 1184.00
IUUC-Pop-099337 Populus trichocarpa 24.86 3.00e-27 116.00
IUUC-Pca-101025 Procavia capensis 65.46 0.00e+00 734.00
IUUC-Ppe-101256 Prunus persica 25.13 1.00e-19 91.30
IUUC-Pva-102453 Pteropus vampyrus 74.00 0.00e+00 831.00
IUUC-Pgr-103436 Puccinia graminis 25.06 5.00e-18 86.30
IUUC-Ptt-103899 Puccinia triticina 28.14 1.00e-18 88.20
IUUC-Pte-104258 Pyrenophora teres 27.45 5.00e-36 145.00
IUUC-Pyt-104625 Pyrenophora triticirepentis 27.99 8.00e-37 148.00
IUUC-Rno-104843 Rattus norvegicus 69.55 0.00e+00 803.00
IUUC-Sce-106189 Saccharomyces cerevisiae 25.81 1.00e-19 91.70
IUUC-Sha-106672 Sarcophilus harrisii 61.22 0.00e+00 703.00
IUUC-Smo-109176 Selaginella moellendorffii 29.63 1.00e-25 110.00
IUUC-Sit-109704 Setaria italica 25.69 5.00e-20 92.40
IUUC-Sly-111853 Solanum lycopersicum 24.94 3.00e-29 123.00
IUUC-Stu-112482 Solanum tuberosum 24.08 3.00e-25 110.00
IUUC-Sar-113537 Sorex araneus 57.11 1.00e-99 357.00
IUUC-Sbi-114517 Sorghum bicolor 27.81 5.00e-17 82.80
IUUC-Sre-114960 Sporisorium reilianum 28.47 2.00e-09 57.80
IUUC-Ssc-115568 Sus scrofa 83.33 0.00e+00 1003.00
IUUC-Tgu-117276 Taeniopygia guttata 49.37 1.00e-119 423.00
IUUC-Tru-117559 Takifugu rubripes 51.20 1.00e-35 141.00
IUUC-Tsy-119234 Tarsius syrichta 64.66 0.00e+00 719.00
IUUC-Tni-120358 Tetraodon nigroviridis 42.11 2.00e-98 352.00
IUUC-Tca-121273 Theobroma cacao 24.72 6.00e-26 112.00
IUUC-Tre-121932 Trichoderma reesei 26.17 1.00e-31 131.00
IUUC-Tvi-122567 Trichoderma virens 26.72 8.00e-34 138.00
IUUC-Tae-123506 Triticum aestivum 26.27 2.00e-14 73.60
IUUC-Tme-126958 Tuber melanosporum 25.35 1.00e-15 77.40
IUUC-Tbe-127425 Tupaia belangeri 85.20 0.00e+00 761.00
IUUC-Ttr-129123 Tursiops truncatus 72.34 0.00e+00 813.00
IUUC-Uma-129495 Ustilago maydis 32.14 2.00e-11 64.70
IUUC-Vda-129981 Verticillium dahliae 26.30 3.00e-29 123.00
IUUC-Vpa-130437 Vicugna pacos 75.59 0.00e+00 857.00
IUUC-Vvi-131430 Vitis vinifera 23.46 2.00e-25 110.00
IUUC-Xtr-132670 Xenopus tropicalis 52.89 3.00e-135 475.00
IUUC-Xma-133375 Xiphophorus maculatus 41.61 5.00e-102 364.00
IUUC-Yli-134341 Yarrowia lipolytica 24.67 3.00e-20 93.20
IUUC-Zma-135413 Zea mays 28.65 3.00e-21 96.30
Created Date 25-Jun-2017

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