iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000090372.14	ENST00000263280.10	ENSP00000263280.4
ENSG00000090372.14	ENST00000391910.7	ENSP00000375777.1
ENSG00000090372.14	ENST00000600615.5	ENSP00000472938.1
ENSG00000090372.14	ENST00000594287.6	ENSP00000470634.2
ENSG00000090372.14	ENST00000600358.7	ENSP00000473446.2
ENSG00000090372.14	ENST00000435164.6	ENSP00000473607.1
ENSG00000090372.14	ENST00000594704.5	ENSP00000471499.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-27	95.8	549	582
UBD/Beta-Prp	7.20e-48	165.0	595	759

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           gH d v++laf ++  +l+s+s Dgt+++WD+++
   Q: 549  GHGDAVWGLAFsPTsQRLASCSADGTVRIWDPSS 582
           8***********7779***************765 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrsl.sgheae...vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           ++ +v t+v+f s +  ++++++r+g + ++d++ g++l +l s  +++   +++v  +p++++ +t+++Dr i+  d +tgk+vh++ +h 
   Q: 595  SEHGVPTSVAFtSTEPAHIVASFRSGDTVLYDMEVGSALLTLeSRGSSGptqINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHL 686
           567899*****999999*********************88885444444566**************************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlW 164
           d v++l+++p+g +l sGshd  +r+w l++++c++e     ++h++++  v+ hp++ l++s+++D   +++
   Q: 687  DAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEitaHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
           *************************************999999************************988887 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN4. Activation of glutamate receptors weakens the interaction with CTTNBP2 (By similarity). Interacts with CTTNBP2NL.

Protein Sequence
(Fasta)

MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG GGSPGPTAGP 60
EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL QGERKGQENL KTDLVRRIKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTTAGCAA CCTTCTCCTG GTGCAGAGTC CTAAGAGGTT TGGGGCTCCA TAACCACAAA 60
GGTGGAAGCG AGGGGAAGGC TGCTCCCCAC CACCTCGCCC CCACCGCTGG GGAAGGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0112--Calmodulin-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0043234--C:protein complex
GO:0070016--F:armadillo repeat domain binding
GO:0005516--F:calmodulin binding
GO:0032403--F:protein complex binding
GO:0051721--F:protein phosphatase 2A binding

KEGG

hsa:29888

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001946	Ailuropoda melanoleuca	80.03	0.00e+00	1003.00
IUUC-Aca-004552	Anolis carolinensis	78.84	0.00e+00	1029.00
IUUC-Acl-008170	Aspergillus clavatus	26.51	3.00e-27	117.00
IUUC-Ame-010825	Astyanax mexicanus	53.60	6.00e-169	587.00
IUUC-Bta-012550	Bos taurus	92.23	0.00e+00	1080.00
IUUC-Cja-018978	Callithrix jacchus	96.45	0.00e+00	990.00
IUUC-Cfa-020268	Canis familiaris	95.53	0.00e+00	1091.00
IUUC-Cpo-022102	Cavia porcellus	94.66	0.00e+00	1108.00
IUUC-Csa-023969	Chlorocebus sabaeus	98.95	0.00e+00	1222.00
IUUC-Dre-027638	Danio rerio	61.15	0.00e+00	815.00
IUUC-Dno-029256	Dasypus novemcinctus	97.26	0.00e+00	672.00
IUUC-Dor-031032	Dipodomys ordii	92.49	0.00e+00	1117.00
IUUC-Eca-033515	Equus caballus	94.30	0.00e+00	1113.00
IUUC-Eeu-035033	Erinaceus europaeus	80.33	5.00e-130	457.00
IUUC-Fca-035749	Felis catus	92.83	0.00e+00	1061.00
IUUC-Gmo-039274	Gadus morhua	60.67	0.00e+00	776.00
IUUC-Gac-042099	Gasterosteus aculeatus	60.47	0.00e+00	790.00
IUUC-Ggo-045406	Gorilla gorilla	100.00	0.00e+00	1179.00
IUUC-Itr-048200	Ictidomys tridecemlineatus	95.80	0.00e+00	1117.00
IUUC-Lch-049604	Latimeria chalumnae	62.68	0.00e+00	815.00
IUUC-Loc-052671	Lepisosteus oculatus	59.24	0.00e+00	821.00
IUUC-Laf-054531	Loxodonta africana	95.57	0.00e+00	1049.00
IUUC-Mcc-055737	Macaca mulatta	93.29	0.00e+00	1159.00
IUUC-Meu-056845	Macropus eugenii	87.24	0.00e+00	1031.00
IUUC-Mmr-061153	Microcebus murinus	97.11	0.00e+00	1200.00
IUUC-Mdo-062739	Monodelphis domestica	82.34	0.00e+00	973.00
IUUC-Mmu-063564	Mus musculus	95.13	0.00e+00	1139.00
IUUC-Mpu-065794	Mustela putorius furo	92.96	0.00e+00	1019.00
IUUC-Nfi-068560	Neosartorya fischeri	26.02	9.00e-27	115.00
IUUC-Nle-069587	Nomascus leucogenys	89.86	0.00e+00	1041.00
IUUC-Opr-071219	Ochotona princeps	73.95	0.00e+00	812.00
IUUC-Ont-071528	Oreochromis niloticus	56.35	0.00e+00	762.00
IUUC-Ocu-073953	Oryctolagus cuniculus	92.09	0.00e+00	964.00
IUUC-Ola-086888	Oryzias latipes	62.14	8.00e-156	544.00
IUUC-Oga-088280	Otolemur garnettii	97.30	0.00e+00	1180.00
IUUC-Oar-090381	Ovis aries	88.50	0.00e+00	990.00
IUUC-Ptr-090704	Pan troglodytes	96.32	0.00e+00	1122.00
IUUC-Pan-092058	Papio anubis	98.82	0.00e+00	1220.00
IUUC-Psi-093535	Pelodiscus sinensis	74.48	0.00e+00	693.00
IUUC-Pfo-096556	Poecilia formosa	60.03	0.00e+00	798.00
IUUC-Pab-098573	Pongo abelii	99.70	0.00e+00	1150.00
IUUC-Pca-100746	Procavia capensis	90.54	0.00e+00	998.00
IUUC-Pva-102823	Pteropus vampyrus	95.07	0.00e+00	1110.00
IUUC-Rno-105418	Rattus norvegicus	95.57	0.00e+00	1133.00
IUUC-Ssc-116050	Sus scrofa	94.18	0.00e+00	893.00
IUUC-Tru-117971	Takifugu rubripes	60.70	0.00e+00	809.00
IUUC-Tni-120522	Tetraodon nigroviridis	61.76	0.00e+00	824.00
IUUC-Tbe-128127	Tupaia belangeri	94.96	0.00e+00	637.00
IUUC-Ttr-128911	Tursiops truncatus	87.99	0.00e+00	1023.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence