iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049496

Ensembl Protein ID

ENSLACP00000011995.1

UniProt Accession

H3AQS4; H3AQS4_LATCH

Genbank Protein ID

ENSLACP00000011995

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AFYH01115647

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010557.1	ENSLACT00000012086.1	ENSLACP00000011995.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.73	9.00e-151	530.00	IUUC-Hsa-046179
E3 activity/RING/RING	81.85	3.00e-152	535.00	IUUC-Mmu-063206
E3 activity/RING/RING	82.15	2.00e-152	535.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Latimeria chalumnae

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSTGPS ANKACGKQQL HAQSSVVPTS ISSGSSLPAT AAVISGQGSV SPQQQELTSL 60
FECPVCFDYV LPPILQCQAG HLVCNQCRQK LSCCPTCRGS LTPSIRNLAM EKVASAVLFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTAATGA GTTACATTGT AGAAGTTAGT GGAAAGCTCT TGTACTCTAT GGGATAATGT 60
TAACCATAGC ACTGCAATAT GGAGTGAAGT AGCATAAGAA AGCCACTAAC TTCTAACTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102365844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	95.72	2.00e-150	525.00
IUUC-Ame-011678	Astyanax mexicanus	91.70	4.00e-142	497.00
IUUC-Bta-012750	Bos taurus	78.55	9.00e-150	522.00
IUUC-Cja-019800	Callithrix jacchus	80.80	4.00e-151	526.00
IUUC-Cfa-020505	Canis familiaris	95.28	2.00e-148	517.00
IUUC-Cpo-021394	Cavia porcellus	82.21	7.00e-156	542.00
IUUC-Csa-023374	Chlorocebus sabaeus	80.80	4.00e-151	526.00
IUUC-Cho-024933	Choloepus hoffmanni	95.67	8.00e-149	518.00
IUUC-Dre-027711	Danio rerio	91.70	4.00e-142	497.00
IUUC-Dno-029260	Dasypus novemcinctus	89.59	5.00e-145	506.00
IUUC-Dor-030489	Dipodomys ordii	93.48	3.00e-105	373.00
IUUC-Ete-032946	Echinops telfairi	82.04	7.00e-154	536.00
IUUC-Eca-033546	Equus caballus	90.97	2.00e-152	530.00
IUUC-Eeu-034861	Erinaceus europaeus	91.83	1.00e-143	501.00
IUUC-Gmo-039091	Gadus morhua	89.72	9.00e-141	492.00
IUUC-Gga-040252	Gallus gallus	81.13	4.00e-150	523.00
IUUC-Gac-041673	Gasterosteus aculeatus	89.72	5.00e-141	493.00
IUUC-Ggo-044618	Gorilla gorilla	80.80	4.00e-151	526.00
IUUC-Hsa-046179	Homo sapiens	80.80	4.00e-151	526.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	94.16	4.00e-148	516.00
IUUC-Loc-052107	Lepisosteus oculatus	92.40	4.00e-142	496.00
IUUC-Laf-054257	Loxodonta africana	95.33	1.00e-148	518.00
IUUC-Mcc-055023	Macaca mulatta	80.80	4.00e-151	526.00
IUUC-Meu-055922	Macropus eugenii	94.49	7.00e-146	509.00
IUUC-Mga-060070	Meleagris gallopavo	85.31	2.00e-144	504.00
IUUC-Mmr-061494	Microcebus murinus	80.80	4.00e-151	526.00
IUUC-Mdo-061971	Monodelphis domestica	95.28	3.00e-148	517.00
IUUC-Mmu-063206	Mus musculus	81.23	1.00e-151	528.00
IUUC-Mpu-066597	Mustela putorius furo	80.80	4.00e-151	526.00
IUUC-Mlu-067199	Myotis lucifugus	95.28	4.00e-148	517.00
IUUC-Nle-069342	Nomascus leucogenys	80.80	4.00e-151	526.00
IUUC-Opr-070341	Ochotona princeps	56.21	3.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	86.13	6.00e-143	499.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.21	7.00e-50	190.00
IUUC-Ocu-073950	Oryctolagus cuniculus	94.98	1.00e-150	525.00
IUUC-Oga-089154	Otolemur garnettii	80.80	4.00e-151	526.00
IUUC-Oar-089446	Ovis aries	94.21	1.00e-149	521.00
IUUC-Ptr-091088	Pan troglodytes	80.80	4.00e-151	526.00
IUUC-Psi-093079	Pelodiscus sinensis	95.04	1.00e-151	528.00
IUUC-Pfo-097007	Poecilia formosa	84.98	2.00e-134	471.00
IUUC-Pab-098092	Pongo abelii	80.80	4.00e-151	526.00
IUUC-Pca-100328	Procavia capensis	79.26	2.00e-147	514.00
IUUC-Pva-102368	Pteropus vampyrus	97.30	2.00e-62	232.00
IUUC-Rno-105477	Rattus norvegicus	81.23	1.00e-151	528.00
IUUC-Sha-107630	Sarcophilus harrisii	94.66	4.00e-151	526.00
IUUC-Ssc-116441	Sus scrofa	80.50	1.00e-150	525.00
IUUC-Tru-118004	Takifugu rubripes	86.96	2.00e-136	478.00
IUUC-Tsy-119548	Tarsius syrichta	87.12	2.00e-65	241.00
IUUC-Tni-120846	Tetraodon nigroviridis	88.93	2.00e-139	488.00
IUUC-Vpa-130799	Vicugna pacos	95.93	3.00e-100	356.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence