iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013518

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase ARIH1; Protein ariadne-1 homolog; RING-type E3 ubiquitin transferase ARIH1

Genbank Nucleotide ID

BC133645

Gene Name

ARIH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006708.5	ENSBTAT00000008822.5	ENSBTAP00000008822.5

Status

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.70e-54	185.3	184	373

Active Site

Position(s)	Description	Evidence
355	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelki.kegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalk 89
           C++C+l+++++ +t  leC h+fC++C+++yl++ki +eg+ ++iscpa+ c   ++++++++l+++++++ +y++l ++++ve+++ lk
   Q: 184  CQICYLNYPNSYFTG-LECGHKFCMQCWSEYLTTKImEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK 272
           **********99985.5**************87775277899************************************************ PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           wcpapdC++vv ++   +++ v+c kcg++fC++C e+wH++++Ck+lk++ +k++   +++e++++++an+k+CpkC+v+iek++gCnh
   Q: 273  WCPAPDCHHVVKVQYP-DAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCD---DDSETSNWIAANTKECPKCHVTIEKDGGCNH 357
           ***************7.9999999.9******************************...99***************************** PP
   S: 180  mtC..akCkaefCwlC 193
           m C  ++CkaefCw+C
   Q: 358  MVCrnQNCKAEFCWVC 373
           ***9999********* PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.

Protein Sequence
(Fasta)

MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDNL DLGEVELVEP GLGVGGERDG 60
LLCGETGGGG GSALGPGGGG GGGGGGGGPG HEQEEDYRYE VLTAEQILQH MVECIREVNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTTGTTG GCTCAGTAGC GGTAGCAGCG GCCGTGGAGG TGGCGCTGGG GACTGTTTTC 60
TCTCGGAGGC CTGAGCGGAG CCGCGTCTGA CTGAGGCGGG CGGCAAGCGG CCCCCTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0015030--C:Cajal body
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0097413--C:Lewy body
GO:0016604--C:nuclear body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

bta:508410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000970	Aegilops tauschii	29.78	2.00e-55	209.00
IUUC-Aml-001385	Ailuropoda melanoleuca	100.00	0.00e+00	927.00
IUUC-Atr-002480	Amborella trichopoda	31.85	7.00e-65	241.00
IUUC-Apl-004184	Anas platyrhynchos	98.42	0.00e+00	876.00
IUUC-Aca-004976	Anolis carolinensis	99.54	0.00e+00	877.00
IUUC-Aly-005807	Arabidopsis lyrata	32.37	2.00e-64	240.00
IUUC-Ath-007166	Arabidopsis thaliana	32.81	1.00e-64	241.00
IUUC-Ago-007926	Ashbya gossypii	29.37	2.00e-55	210.00
IUUC-Acl-008252	Aspergillus clavatus	42.49	2.00e-104	373.00
IUUC-Afl-008468	Aspergillus flavus	42.95	8.00e-106	377.00
IUUC-Afu-009062	Aspergillus fumigatus	44.69	2.00e-106	379.00
IUUC-Ani-009219	Aspergillus nidulans	42.73	1.00e-106	380.00
IUUC-Ang-009538	Aspergillus niger	43.29	1.00e-98	353.00
IUUC-Aor-010009	Aspergillus oryzae	42.95	4.00e-105	375.00
IUUC-Ate-010497	Aspergillus terreus	44.25	7.00e-99	354.00
IUUC-Ame-011264	Astyanax mexicanus	89.94	0.00e+00	961.00
IUUC-Bgr-012016	Blumeria graminis	41.19	3.00e-102	365.00
IUUC-Bci-013819	Botrytis cinerea	42.46	7.00e-107	380.00
IUUC-Bdi-014685	Brachypodium distachyon	32.59	3.00e-67	249.00
IUUC-Bol-016087	Brassica oleracea	31.94	1.00e-60	227.00
IUUC-Bra-017944	Brassica rapa	33.10	1.00e-55	211.00
IUUC-Cel-018521	Caenorhabditis elegans	55.04	4.00e-138	484.00
IUUC-Cja-019869	Callithrix jacchus	92.52	0.00e+00	845.00
IUUC-Cfa-020812	Canis familiaris	99.78	0.00e+00	932.00
IUUC-Cpo-021627	Cavia porcellus	100.00	0.00e+00	939.00
IUUC-Csa-023034	Chlorocebus sabaeus	100.00	0.00e+00	873.00
IUUC-Cho-024444	Choloepus hoffmanni	97.20	0.00e+00	905.00
IUUC-Cin-025135	Ciona intestinalis	69.11	0.00e+00	685.00
IUUC-Csv-026243	Ciona savignyi	68.39	0.00e+00	664.00
IUUC-Cgl-026434	Colletotrichum gloeosporioides	42.40	2.00e-107	382.00
IUUC-Cne-026861	Cryptococcus neoformans	41.98	4.00e-102	365.00
IUUC-Dre-027785	Danio rerio	90.14	0.00e+00	962.00
IUUC-Dno-029205	Dasypus novemcinctus	100.00	0.00e+00	939.00
IUUC-Dor-030769	Dipodomys ordii	82.18	0.00e+00	723.00
IUUC-Dse-031171	Dothistroma septosporum	42.46	2.00e-105	375.00
IUUC-Dme-031903	Drosophila melanogaster	70.35	0.00e+00	698.00
IUUC-Ete-032929	Echinops telfairi	84.30	1.00e-135	476.00
IUUC-Eca-033431	Equus caballus	99.78	0.00e+00	895.00
IUUC-Eeu-034838	Erinaceus europaeus	86.34	0.00e+00	753.00
IUUC-Fca-035882	Felis catus	95.88	0.00e+00	788.00
IUUC-Fal-037068	Ficedula albicollis	99.55	0.00e+00	895.00
IUUC-Fox-037790	Fusarium oxysporum	49.82	1.00e-77	282.00
IUUC-Fso-038125	Fusarium solani	42.25	2.00e-105	376.00
IUUC-Gmo-038703	Gadus morhua	90.35	0.00e+00	957.00
IUUC-Ggr-039722	Gaeumannomyces graminis	41.54	2.00e-105	375.00
IUUC-Gga-040319	Gallus gallus	100.00	0.00e+00	697.00
IUUC-Gac-041708	Gasterosteus aculeatus	96.73	0.00e+00	944.00
IUUC-Gma-043188	Glycine max	32.35	5.00e-60	225.00
IUUC-Ggo-045178	Gorilla gorilla	100.00	0.00e+00	939.00
IUUC-Hsa-045718	Homo sapiens	100.00	0.00e+00	939.00
IUUC-Hvu-047322	Hordeum vulgare	31.87	8.00e-59	221.00
IUUC-Itr-048934	Ictidomys tridecemlineatus	100.00	9.00e-178	615.00
IUUC-Kpa-049350	Komagataella pastoris	31.68	8.00e-65	241.00
IUUC-Lpe-051110	Leersia perrieri	33.18	4.00e-68	252.00
IUUC-Loc-052442	Lepisosteus oculatus	91.49	0.00e+00	972.00
IUUC-Lma-053253	Leptosphaeria maculans	42.83	1.00e-111	397.00
IUUC-Laf-054351	Loxodonta africana	100.00	0.00e+00	873.00
IUUC-Mcc-054670	Macaca mulatta	96.56	0.00e+00	927.00
IUUC-Meu-056335	Macropus eugenii	92.11	2.00e-142	498.00
IUUC-Mor-057179	Magnaporthe oryzae	42.00	1.00e-105	377.00
IUUC-Mpo-057553	Magnaporthe poae	41.33	2.00e-104	372.00
IUUC-Mtr-058263	Medicago truncatula	31.88	5.00e-58	218.00
IUUC-Mla-058889	Melampsora laricipopulina	36.76	4.00e-78	285.00
IUUC-Mga-059385	Meleagris gallopavo	98.21	0.00e+00	882.00
IUUC-Mvi-060517	Microbotryum violaceum	40.74	4.00e-105	375.00
IUUC-Mmr-061439	Microcebus murinus	93.38	0.00e+00	854.00
IUUC-Mdo-062890	Monodelphis domestica	99.78	0.00e+00	937.00
IUUC-Mmu-063433	Mus musculus	100.00	0.00e+00	939.00
IUUC-Mac-065341	Musa acuminata	33.79	2.00e-64	240.00
IUUC-Mpu-066288	Mustela putorius furo	100.00	0.00e+00	939.00
IUUC-Mlu-067187	Myotis lucifugus	99.78	0.00e+00	932.00
IUUC-Nfi-068339	Neosartorya fischeri	44.47	8.00e-106	377.00
IUUC-Ncr-068947	Neurospora crassa	43.53	3.00e-103	369.00
IUUC-Nle-069263	Nomascus leucogenys	100.00	0.00e+00	939.00
IUUC-Opr-071000	Ochotona princeps	100.00	1.00e-97	350.00
IUUC-Ont-072309	Oreochromis niloticus	96.53	0.00e+00	940.00
IUUC-Oan-073731	Ornithorhynchus anatinus	100.00	0.00e+00	831.00
IUUC-Ocu-074000	Oryctolagus cuniculus	98.19	0.00e+00	876.00
IUUC-Oba-075628	Oryza barthii	31.84	9.00e-62	231.00
IUUC-Obr-076492	Oryza brachyantha	32.74	2.00e-68	253.00
IUUC-Ogl-077447	Oryza glaberrima	33.18	5.00e-69	255.00
IUUC-Ogu-078881	Oryza glumaepatula	32.97	6.00e-69	255.00
IUUC-Oin-079573	Oryza indica	33.18	6.00e-67	248.00
IUUC-Olo-080774	Oryza longistaminata	33.19	2.00e-69	256.00
IUUC-Ome-081275	Oryza meridionalis	31.83	2.00e-61	229.00
IUUC-Oni-082267	Oryza nivara	31.83	2.00e-61	229.00
IUUC-Opu-084135	Oryza punctata	33.18	5.00e-69	255.00
IUUC-Oru-084849	Oryza rufipogon	32.97	1.00e-68	254.00
IUUC-Osa-085435	Oryza sativa	33.18	1.00e-68	254.00
IUUC-Ola-086792	Oryzias latipes	96.53	0.00e+00	939.00
IUUC-Olu-087826	Ostreococcus lucimarinus	32.90	3.00e-50	192.00
IUUC-Oga-088706	Otolemur garnettii	100.00	0.00e+00	939.00
IUUC-Oar-089354	Ovis aries	99.78	0.00e+00	937.00
IUUC-Ptr-091287	Pan troglodytes	100.00	0.00e+00	939.00
IUUC-Pan-091701	Papio anubis	100.00	0.00e+00	873.00
IUUC-Psi-093814	Pelodiscus sinensis	100.00	0.00e+00	873.00
IUUC-Pno-095124	Phaeosphaeria nodorum	35.71	6.00e-79	288.00
IUUC-Ppa-095545	Physcomitrella patens	32.44	2.00e-61	230.00
IUUC-Pfo-096449	Poecilia formosa	96.53	0.00e+00	940.00
IUUC-Pab-098132	Pongo abelii	100.00	0.00e+00	939.00
IUUC-Pop-099139	Populus trichocarpa	32.27	8.00e-64	238.00
IUUC-Pca-100303	Procavia capensis	99.70	0.00e+00	652.00
IUUC-Ppe-101740	Prunus persica	31.79	2.00e-59	223.00
IUUC-Pva-102457	Pteropus vampyrus	100.00	0.00e+00	939.00
IUUC-Pgr-103443	Puccinia graminis	42.53	7.00e-104	371.00
IUUC-Ptt-103795	Puccinia triticina	39.88	5.00e-93	335.00
IUUC-Pte-104022	Pyrenophora teres	40.77	5.00e-102	365.00
IUUC-Pyt-104643	Pyrenophora triticirepentis	42.37	7.00e-110	390.00
IUUC-Rno-106083	Rattus norvegicus	100.00	0.00e+00	939.00
IUUC-Sce-106154	Saccharomyces cerevisiae	30.63	2.00e-64	239.00
IUUC-Sha-106765	Sarcophilus harrisii	97.75	0.00e+00	882.00
IUUC-Sja-107977	Schizosaccharomyces japonicus	43.59	1.00e-98	353.00
IUUC-Spo-108222	Schizosaccharomyces pombe	44.73	4.00e-111	394.00
IUUC-Smo-109078	Selaginella moellendorffii	32.71	5.00e-59	222.00
IUUC-Sit-110348	Setaria italica	32.14	8.00e-65	241.00
IUUC-Sly-111454	Solanum lycopersicum	32.79	2.00e-61	229.00
IUUC-Stu-112599	Solanum tuberosum	32.95	2.00e-58	220.00
IUUC-Sar-113023	Sorex araneus	99.77	0.00e+00	867.00
IUUC-Sbi-114262	Sorghum bicolor	32.81	2.00e-66	246.00
IUUC-Sre-115120	Sporisorium reilianum	44.80	2.00e-110	392.00
IUUC-Ssc-115667	Sus scrofa	89.47	0.00e+00	628.00
IUUC-Tgu-117273	Taeniopygia guttata	99.54	0.00e+00	873.00
IUUC-Tru-118338	Takifugu rubripes	86.76	0.00e+00	938.00
IUUC-Tsy-119096	Tarsius syrichta	91.67	0.00e+00	778.00
IUUC-Tni-120238	Tetraodon nigroviridis	86.69	0.00e+00	934.00
IUUC-Tca-121037	Theobroma cacao	33.33	2.00e-66	246.00
IUUC-Tre-121902	Trichoderma reesei	41.89	1.00e-103	370.00
IUUC-Tvi-122474	Trichoderma virens	41.19	5.00e-104	371.00
IUUC-Tae-124132	Triticum aestivum	33.11	1.00e-67	251.00
IUUC-Tur-126320	Triticum urartu	30.75	4.00e-55	209.00
IUUC-Tme-127089	Tuber melanosporum	42.92	2.00e-104	372.00
IUUC-Tbe-127409	Tupaia belangeri	93.09	9.00e-122	430.00
IUUC-Ttr-128909	Tursiops truncatus	90.85	0.00e+00	815.00
IUUC-Uma-129487	Ustilago maydis	42.49	4.00e-111	394.00
IUUC-Vda-129939	Verticillium dahliae	42.18	7.00e-106	377.00
IUUC-Vpa-130259	Vicugna pacos	96.77	0.00e+00	896.00
IUUC-Vvi-131463	Vitis vinifera	32.52	1.00e-58	221.00
IUUC-Xtr-132219	Xenopus tropicalis	99.13	0.00e+00	922.00
IUUC-Xma-133423	Xiphophorus maculatus	96.53	0.00e+00	940.00
IUUC-Yli-134622	Yarrowia lipolytica	35.65	2.00e-73	270.00
IUUC-Zma-135131	Zea mays	33.11	9.00e-67	248.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence