iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062015

UUCD1 version

UUC-MoD-00163

Ensembl Protein ID

ENSMODP00000012963.3

UniProt Accession

F6S8D8; F6S8D8_MONDO

Protein Name

Uncharacterized protein

Gene Name

CUL4B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000010345.3	ENSMODT00000013200.3	ENSMODP00000012963.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	9.70e-217	721.6	223	818

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++k++a+lYk+l++++ee+i  q+ + +e s d+  +Lk++ ++W+++++q+ ++r+if
   Q: 223  KLKEAVEAIQKSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEEHIrFQIFQFREGSLDSVlFLKKIDKCWQNHCRQMIMIRSIF 311
           589***********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r++i++d  ++++++e +l lie+eR+gea+dr+ll+++ ++l++L     +iy++sFE+kfle
   Q: 312  LFLDRTYVLQNSMLPSIWDMGLELFRTHIISDqkVQNKTIEGILLLIERERTGEAIDRSLLRSLLSMLSDL-----QIYQDSFEQKFLE 395
           ********************************9**********************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+++y+ae ++++qe+ev eYl++v+ rl+ee +r+ +yl+ st+++L+++vek+l+ +hl+++l ++l++ll++++ +dls++y+L+
   Q: 396  ETNRLYSAEGQRLMQEREVPEYLHHVNRRLEEEADRLITYLDLSTQKPLIATVEKQLLGEHLTAILqKGLNHLLDENRIQDLSLLYQLF 484
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           +rv+ g++ ll+++ ++ik  g+++++++ek+k+   +V++ll++k+k++++++ +F +++kF++a+++afetf+nk+     +++p E
   Q: 485  TRVRSGVQVLLQHWIEYIKAFGSTIVINPEKDKT---MVQELLDFKDKVDHIIDICFMKNEKFVNAMKEAFETFINKR-----PNKPaE 565
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i +kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 566  LIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 654
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d++ qFk+  +n++   s+el+v++L++g+Wpt+  +e v+LPae+ +++e+f++fYl khsgRkLqWq tlg++ lkae+k+
   Q: 655  DMELSKDIMVQFKQYIQNQNFPGSIELTVNILTMGYWPTYVPME-VHLPAEMVRLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKE 742
           ******************************************99.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+elqVs fQ++vLL+fn++e++s+e++++at++++ eLrrtlqsL+++k++vl k+p++k++e++d+f++N++f
   Q: 743  GKKELQVSLFQTLVLLMFNENEEFSLEDIRHATGIEDGELRRTLQSLACGKARVLAKNPKGKDVEDGDKFICNDDF 818
           **************************************************************************98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGSGFSSPNP PAAAAASSQE VRSATDGHNS TSPTSAAASC SKKRKLNSSS SSNSSSISSS 60
SSSSNSSSSS SSCSSNEKED FDPVPSSCSS PPPPLPKNSS TSSSTTSYPG ISFATPNHHH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTCTGTC GAATTAAAGT TAAAGTTGTT CGCCTGTGAG ATTCCTCTCA GGTCTAGATT 60
TAAGTCCTCT AGTTTAAAAG CCGCTGCGGC CTAACTGCGC AGCTCTCGAA GGCCCAGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0035518--P:histone H2A monoubiquitination
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0045732--P:positive regulation of protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070914--P:UV-damage excision repair

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000285	Aegilops tauschii	56.90	0.00e+00	820.00
IUUC-Aml-002062	Ailuropoda melanoleuca	86.47	0.00e+00	1492.00
IUUC-Atr-002727	Amborella trichopoda	57.94	0.00e+00	808.00
IUUC-Apl-004157	Anas platyrhynchos	93.15	0.00e+00	1481.00
IUUC-Aca-004430	Anolis carolinensis	90.71	0.00e+00	1433.00
IUUC-Aly-006547	Arabidopsis lyrata	57.80	0.00e+00	813.00
IUUC-Ath-006748	Arabidopsis thaliana	57.22	0.00e+00	807.00
IUUC-Acl-008359	Aspergillus clavatus	35.95	3.00e-124	439.00
IUUC-Afl-008567	Aspergillus flavus	38.02	4.00e-133	468.00
IUUC-Ame-011580	Astyanax mexicanus	87.47	0.00e+00	1402.00
IUUC-Bgr-012219	Blumeria graminis	36.38	3.00e-114	406.00
IUUC-Bta-013244	Bos taurus	86.33	0.00e+00	1486.00
IUUC-Bci-013744	Botrytis cinerea	40.03	2.00e-128	452.00
IUUC-Bdi-014223	Brachypodium distachyon	55.07	0.00e+00	819.00
IUUC-Bol-016036	Brassica oleracea	57.97	0.00e+00	830.00
IUUC-Bra-017794	Brassica rapa	57.45	0.00e+00	831.00
IUUC-Cja-019180	Callithrix jacchus	86.59	0.00e+00	1496.00
IUUC-Cfa-021189	Canis familiaris	86.81	0.00e+00	1498.00
IUUC-Cpo-021928	Cavia porcellus	85.92	0.00e+00	1477.00
IUUC-Cre-022739	Chlamydomonas reinhardtii	46.89	4.00e-178	618.00
IUUC-Csa-023831	Chlorocebus sabaeus	86.59	0.00e+00	1496.00
IUUC-Csv-026117	Ciona savignyi	52.95	0.00e+00	841.00
IUUC-Cgl-026761	Colletotrichum gloeosporioides	39.67	8.00e-125	441.00
IUUC-Dre-027916	Danio rerio	88.51	0.00e+00	1399.00
IUUC-Dno-029483	Dasypus novemcinctus	78.04	0.00e+00	1346.00
IUUC-Dse-031159	Dothistroma septosporum	36.61	2.00e-121	430.00
IUUC-Dme-031652	Drosophila melanogaster	64.54	0.00e+00	931.00
IUUC-Ete-032775	Echinops telfairi	76.20	0.00e+00	1226.00
IUUC-Eca-033952	Equus caballus	85.32	0.00e+00	1452.00
IUUC-Eeu-034767	Erinaceus europaeus	81.88	0.00e+00	1357.00
IUUC-Fca-036211	Felis catus	92.05	0.00e+00	1424.00
IUUC-Fal-037248	Ficedula albicollis	93.39	0.00e+00	1479.00
IUUC-Fox-037854	Fusarium oxysporum	38.38	2.00e-123	436.00
IUUC-Fso-038138	Fusarium solani	38.62	2.00e-126	446.00
IUUC-Gmo-038754	Gadus morhua	87.12	0.00e+00	1384.00
IUUC-Ggr-040003	Gaeumannomyces graminis	36.15	1.00e-101	364.00
IUUC-Gga-041002	Gallus gallus	93.63	0.00e+00	1487.00
IUUC-Gac-041555	Gasterosteus aculeatus	87.20	0.00e+00	1389.00
IUUC-Gma-043960	Glycine max	59.38	0.00e+00	841.00
IUUC-Ggo-045468	Gorilla gorilla	86.11	0.00e+00	1431.00
IUUC-Hsa-046848	Homo sapiens	86.59	0.00e+00	1498.00
IUUC-Itr-048365	Ictidomys tridecemlineatus	85.81	0.00e+00	1476.00
IUUC-Lch-049858	Latimeria chalumnae	90.36	0.00e+00	1462.00
IUUC-Lpe-051446	Leersia perrieri	56.10	0.00e+00	817.00
IUUC-Loc-052415	Lepisosteus oculatus	87.90	0.00e+00	1415.00
IUUC-Lma-053080	Leptosphaeria maculans	35.96	2.00e-129	457.00
IUUC-Laf-053701	Loxodonta africana	85.73	0.00e+00	1479.00
IUUC-Mcc-055538	Macaca mulatta	85.03	0.00e+00	1462.00
IUUC-Mor-057102	Magnaporthe oryzae	35.87	1.00e-117	417.00
IUUC-Mpo-057342	Magnaporthe poae	37.15	6.00e-101	361.00
IUUC-Mtr-058660	Medicago truncatula	57.56	0.00e+00	830.00
IUUC-Mla-058936	Melampsora laricipopulina	40.24	3.00e-114	405.00
IUUC-Mga-059754	Meleagris gallopavo	93.40	0.00e+00	1478.00
IUUC-Mvi-060455	Microbotryum violaceum	41.78	3.00e-143	502.00
IUUC-Mmr-060870	Microcebus murinus	85.70	0.00e+00	1475.00
IUUC-Mmu-063751	Mus musculus	84.97	0.00e+00	1462.00
IUUC-Mac-064443	Musa acuminata	57.01	0.00e+00	840.00
IUUC-Mpu-065903	Mustela putorius furo	86.36	0.00e+00	1495.00
IUUC-Mlu-068213	Myotis lucifugus	86.47	0.00e+00	1497.00
IUUC-Ncr-068950	Neurospora crassa	36.93	5.00e-118	419.00
IUUC-Nle-069480	Nomascus leucogenys	86.59	0.00e+00	1496.00
IUUC-Opr-071164	Ochotona princeps	71.29	5.00e-140	491.00
IUUC-Oan-073607	Ornithorhynchus anatinus	93.13	0.00e+00	1466.00
IUUC-Ocu-074446	Oryctolagus cuniculus	86.70	0.00e+00	1494.00
IUUC-Oba-075198	Oryza barthii	56.38	0.00e+00	821.00
IUUC-Obr-076095	Oryza brachyantha	56.38	0.00e+00	822.00
IUUC-Ogl-077032	Oryza glaberrima	56.38	0.00e+00	820.00
IUUC-Ogu-078051	Oryza glumaepatula	56.90	0.00e+00	820.00
IUUC-Oin-079399	Oryza indica	60.07	0.00e+00	721.00
IUUC-Olo-080988	Oryza longistaminata	55.56	0.00e+00	811.00
IUUC-Ome-081600	Oryza meridionalis	55.69	0.00e+00	813.00
IUUC-Oni-082623	Oryza nivara	55.69	0.00e+00	813.00
IUUC-Opu-083762	Oryza punctata	55.44	0.00e+00	811.00
IUUC-Oru-084499	Oryza rufipogon	56.38	0.00e+00	821.00
IUUC-Ola-087157	Oryzias latipes	87.27	0.00e+00	1379.00
IUUC-Olu-087650	Ostreococcus lucimarinus	48.72	3.00e-180	625.00
IUUC-Oga-088416	Otolemur garnettii	84.22	0.00e+00	1425.00
IUUC-Oar-090230	Ovis aries	86.33	0.00e+00	1485.00
IUUC-Ptr-091153	Pan troglodytes	91.49	0.00e+00	1484.00
IUUC-Pan-091729	Papio anubis	86.59	0.00e+00	1496.00
IUUC-Psi-093773	Pelodiscus sinensis	93.06	0.00e+00	1479.00
IUUC-Pma-094678	Petromyzon marinus	84.24	0.00e+00	1038.00
IUUC-Pno-094946	Phaeosphaeria nodorum	34.87	8.00e-109	388.00
IUUC-Ppa-095688	Physcomitrella patens	60.86	0.00e+00	882.00
IUUC-Pfo-096828	Poecilia formosa	88.24	0.00e+00	1399.00
IUUC-Pab-097816	Pongo abelii	79.05	0.00e+00	1320.00
IUUC-Pca-100858	Procavia capensis	66.74	0.00e+00	1055.00
IUUC-Ppe-101142	Prunus persica	59.53	0.00e+00	844.00
IUUC-Pva-102995	Pteropus vampyrus	79.89	0.00e+00	1377.00
IUUC-Pgr-103334	Puccinia graminis	37.55	2.00e-105	377.00
IUUC-Pte-104167	Pyrenophora teres	35.35	4.00e-127	449.00
IUUC-Pyt-104736	Pyrenophora triticirepentis	35.57	2.00e-126	446.00
IUUC-Rno-106119	Rattus norvegicus	85.51	0.00e+00	1469.00
IUUC-Sha-106958	Sarcophilus harrisii	91.81	0.00e+00	1554.00
IUUC-Sja-107940	Schizosaccharomyces japonicus	33.70	5.00e-109	388.00
IUUC-Spo-108109	Schizosaccharomyces pombe	33.71	1.00e-109	390.00
IUUC-Ssl-108537	Sclerotinia sclerotiorum	39.13	1.00e-126	447.00
IUUC-Smo-109313	Selaginella moellendorffii	59.36	0.00e+00	895.00
IUUC-Sit-110626	Setaria italica	56.59	0.00e+00	826.00
IUUC-Sly-111497	Solanum lycopersicum	58.93	0.00e+00	851.00
IUUC-Sar-113581	Sorex araneus	81.46	0.00e+00	1003.00
IUUC-Sbi-113931	Sorghum bicolor	56.59	0.00e+00	827.00
IUUC-Tgu-116462	Taeniopygia guttata	93.03	0.00e+00	1472.00
IUUC-Tru-118299	Takifugu rubripes	88.22	0.00e+00	1400.00
IUUC-Tsy-119517	Tarsius syrichta	95.99	0.00e+00	702.00
IUUC-Tni-120811	Tetraodon nigroviridis	86.58	0.00e+00	1370.00
IUUC-Tca-121626	Theobroma cacao	56.63	0.00e+00	841.00
IUUC-Tae-123442	Triticum aestivum	56.90	0.00e+00	821.00
IUUC-Tur-126032	Triticum urartu	56.90	0.00e+00	820.00
IUUC-Tbe-127658	Tupaia belangeri	83.85	0.00e+00	1398.00
IUUC-Ttr-129112	Tursiops truncatus	78.94	0.00e+00	1329.00
IUUC-Vda-129701	Verticillium dahliae	38.58	4.00e-133	468.00
IUUC-Vpa-130217	Vicugna pacos	78.82	0.00e+00	1323.00
IUUC-Vvi-131133	Vitis vinifera	59.47	0.00e+00	851.00
IUUC-Xtr-132724	Xenopus tropicalis	89.88	0.00e+00	1426.00
IUUC-Xma-134149	Xiphophorus maculatus	88.47	0.00e+00	1408.00
IUUC-Zma-135529	Zea mays	56.73	0.00e+00	827.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence