iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ola-087052

Ensembl Protein ID

ENSORLP00000018192.1

UniProt Accession

H2MHS4; H2MHS4_ORYLA

Genbank Protein ID

ENSORLP00000018192

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

BAAF04020431

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000014514.1	ENSORLT00000018193.1	ENSORLP00000018192.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	51.31	7.00e-125	445.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oryzias latipes

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MLLRQSSVQI RQLFGPALRS RISPASSELE TLSPPRLSPR DPLGDMYPEE SRGSGGVAAV 60
DFLEGTYDYA APNPATTPLY SQSSTGYYSA PLETNGPPSE GSLQSLGSGP TSPLVFVPSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGCTCA GACAGAGCTC GGTGCAGATC AGGCAGCTGT TCGGACCAGC ACTCAGATCC 60
AGGATCAGCC CAGCCTCCTC AGAGCTGGAG ACCCTCTCCC CACCTCGCCT CTCGCCCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	60.29	1.00e-128	452.00
IUUC-Apl-003688	Anas platyrhynchos	52.06	3.00e-131	461.00
IUUC-Aca-005222	Anolis carolinensis	50.27	1.00e-134	473.00
IUUC-Ame-010731	Astyanax mexicanus	63.29	5.00e-170	590.00
IUUC-Bta-013112	Bos taurus	49.01	3.00e-134	471.00
IUUC-Cja-019408	Callithrix jacchus	48.51	3.00e-131	461.00
IUUC-Cfa-020694	Canis familiaris	51.91	5.00e-131	461.00
IUUC-Cpo-021426	Cavia porcellus	49.16	7.00e-127	447.00
IUUC-Csa-023736	Chlorocebus sabaeus	54.43	6.00e-132	464.00
IUUC-Dre-027698	Danio rerio	61.54	1.00e-171	596.00
IUUC-Dno-029477	Dasypus novemcinctus	58.75	2.00e-127	449.00
IUUC-Dor-030572	Dipodomys ordii	57.28	2.00e-126	445.00
IUUC-Ete-032849	Echinops telfairi	46.49	7.00e-84	304.00
IUUC-Eca-033605	Equus caballus	49.42	4.00e-134	471.00
IUUC-Eeu-034683	Erinaceus europaeus	53.16	3.00e-54	205.00
IUUC-Fca-035928	Felis catus	60.10	4.00e-128	451.00
IUUC-Fal-036754	Ficedula albicollis	53.55	7.00e-144	503.00
IUUC-Gmo-038872	Gadus morhua	72.28	2.00e-161	561.00
IUUC-Gga-040988	Gallus gallus	53.19	1.00e-140	493.00
IUUC-Gac-042015	Gasterosteus aculeatus	80.42	0.00e+00	718.00
IUUC-Ggo-044749	Gorilla gorilla	59.95	1.00e-130	460.00
IUUC-Hsa-046944	Homo sapiens	60.39	2.00e-131	462.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	48.41	4.00e-130	458.00
IUUC-Loc-052414	Lepisosteus oculatus	61.92	0.00e+00	632.00
IUUC-Mcc-054781	Macaca mulatta	59.71	2.00e-130	459.00
IUUC-Meu-056232	Macropus eugenii	50.17	8.00e-129	453.00
IUUC-Mga-059319	Meleagris gallopavo	53.19	2.00e-140	492.00
IUUC-Mmr-061636	Microcebus murinus	53.61	3.00e-55	209.00
IUUC-Mdo-062661	Monodelphis domestica	52.89	2.00e-132	465.00
IUUC-Mmu-063330	Mus musculus	50.44	5.00e-130	457.00
IUUC-Mpu-065757	Mustela putorius furo	48.84	2.00e-134	473.00
IUUC-Mlu-067712	Myotis lucifugus	55.60	2.00e-129	456.00
IUUC-Nle-069283	Nomascus leucogenys	55.82	4.00e-131	461.00
IUUC-Opr-070391	Ochotona princeps	54.62	7.00e-129	454.00
IUUC-Ont-071369	Oreochromis niloticus	81.58	0.00e+00	759.00
IUUC-Oan-073734	Ornithorhynchus anatinus	40.41	6.00e-58	217.00
IUUC-Ocu-074292	Oryctolagus cuniculus	49.09	2.00e-131	462.00
IUUC-Oga-088586	Otolemur garnettii	50.42	2.00e-130	459.00
IUUC-Oar-090156	Ovis aries	59.90	2.00e-130	459.00
IUUC-Ptr-091321	Pan troglodytes	59.95	1.00e-130	460.00
IUUC-Pan-092851	Papio anubis	59.71	2.00e-130	459.00
IUUC-Psi-093434	Pelodiscus sinensis	50.95	4.00e-139	488.00
IUUC-Pfo-097379	Poecilia formosa	82.09	0.00e+00	816.00
IUUC-Pab-097735	Pongo abelii	59.95	1.00e-130	460.00
IUUC-Pva-102125	Pteropus vampyrus	48.67	1.00e-131	463.00
IUUC-Rno-106121	Rattus norvegicus	49.83	2.00e-130	459.00
IUUC-Sha-107547	Sarcophilus harrisii	51.70	1.00e-130	459.00
IUUC-Sar-113650	Sorex araneus	44.68	3.00e-74	271.00
IUUC-Tgu-117175	Taeniopygia guttata	53.19	1.00e-142	499.00
IUUC-Tru-117545	Takifugu rubripes	76.39	0.00e+00	763.00
IUUC-Tsy-119586	Tarsius syrichta	55.38	2.00e-111	395.00
IUUC-Tni-120121	Tetraodon nigroviridis	73.09	0.00e+00	756.00
IUUC-Tbe-127548	Tupaia belangeri	51.71	8.00e-102	364.00
IUUC-Ttr-128374	Tursiops truncatus	57.21	4.00e-117	414.00
IUUC-Vpa-130464	Vicugna pacos	47.24	1.00e-81	296.00
IUUC-Xtr-132171	Xenopus tropicalis	53.96	6.00e-134	471.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence