iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066834

Ensembl Protein ID

ENSMPUP00000017416.1

UniProt Accession

G9KSM3; G9KSM3_MUSPF

Genbank Protein ID

AES07902.1

Protein Name

TANK-binding kinase 1

Genbank Nucleotide ID

AEYP01031674

Gene Name

TBK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017528.1	ENSMPUT00000017674.1	ENSMPUP00000017416.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	8.10e-06	25.6	311	386

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL..eddktLady.glkdgstihllekks 74
           ++v sl+ +  +++ +++++t  ++ e ++k+++i +  q Liy+G+ L  e+++ ++++ + ++++ i+++ +++
   Q: 311  IHVFSLQQMtAHKIYIHSYNTATVFHELVYKQTKIISSNQELIYEGRRLvvEPGRLVQHFpKTTEENPIFVVSREP 386
           7899999999*************************************************************99876 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAACAAGA ACTCCTGACC AAGCCAAAAT GCAGAGCACT TCTAATCATC TGTGGCTTTT 60
ATCTGATATT TTAGGCCAAG GAGCTACTGC AAATGTCTTT CGTGGAAGGC ATAAGGTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003676--F:nucleic acid binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0002218--P:activation of innate immune response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0044565--P:dendritic cell proliferation
GO:0010629--P:negative regulation of gene expression
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1904417--P:positive regulation of xenophagy

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001638	Ailuropoda melanoleuca	99.18	0.00e+00	1510.00
IUUC-Apl-004028	Anas platyrhynchos	87.38	0.00e+00	1362.00
IUUC-Aca-004998	Anolis carolinensis	82.72	0.00e+00	1291.00
IUUC-Ame-011617	Astyanax mexicanus	71.03	0.00e+00	1069.00
IUUC-Bta-012799	Bos taurus	98.08	0.00e+00	1502.00
IUUC-Cja-019357	Callithrix jacchus	97.53	0.00e+00	1491.00
IUUC-Cfa-020309	Canis familiaris	98.35	0.00e+00	1502.00
IUUC-Cpo-022062	Cavia porcellus	96.57	0.00e+00	1473.00
IUUC-Csa-023517	Chlorocebus sabaeus	97.53	0.00e+00	1496.00
IUUC-Cho-025037	Choloepus hoffmanni	94.55	0.00e+00	982.00
IUUC-Cin-025580	Ciona intestinalis	40.88	4.00e-151	528.00
IUUC-Csv-025818	Ciona savignyi	40.84	5.00e-146	511.00
IUUC-Dre-027527	Danio rerio	71.11	0.00e+00	1082.00
IUUC-Dno-029475	Dasypus novemcinctus	85.67	0.00e+00	1138.00
IUUC-Dme-031698	Drosophila melanogaster	39.56	3.00e-133	469.00
IUUC-Ete-033090	Echinops telfairi	83.26	0.00e+00	1235.00
IUUC-Eca-033996	Equus caballus	96.16	0.00e+00	1480.00
IUUC-Eeu-035082	Erinaceus europaeus	88.70	0.00e+00	866.00
IUUC-Fca-035921	Felis catus	95.22	0.00e+00	1443.00
IUUC-Fal-037406	Ficedula albicollis	87.52	0.00e+00	1368.00
IUUC-Gmo-038721	Gadus morhua	70.91	0.00e+00	1051.00
IUUC-Gga-041234	Gallus gallus	86.97	0.00e+00	1361.00
IUUC-Gac-042315	Gasterosteus aculeatus	71.59	0.00e+00	1070.00
IUUC-Ggo-044885	Gorilla gorilla	90.95	0.00e+00	1376.00
IUUC-Hsa-046847	Homo sapiens	97.39	0.00e+00	1493.00
IUUC-Itr-047906	Ictidomys tridecemlineatus	96.33	0.00e+00	1473.00
IUUC-Lch-049731	Latimeria chalumnae	54.34	0.00e+00	776.00
IUUC-Loc-051879	Lepisosteus oculatus	72.94	0.00e+00	1109.00
IUUC-Laf-054232	Loxodonta africana	95.75	0.00e+00	1469.00
IUUC-Mcc-055447	Macaca mulatta	97.67	0.00e+00	1497.00
IUUC-Meu-056138	Macropus eugenii	96.98	0.00e+00	683.00
IUUC-Mga-059460	Meleagris gallopavo	85.77	0.00e+00	1333.00
IUUC-Mmr-061445	Microcebus murinus	97.67	0.00e+00	1491.00
IUUC-Mmu-064107	Mus musculus	94.38	0.00e+00	1438.00
IUUC-Mlu-068006	Myotis lucifugus	94.11	0.00e+00	1416.00
IUUC-Nle-069280	Nomascus leucogenys	97.26	0.00e+00	1491.00
IUUC-Opr-070728	Ochotona princeps	89.28	0.00e+00	1201.00
IUUC-Ont-071621	Oreochromis niloticus	72.74	0.00e+00	1087.00
IUUC-Oan-073162	Ornithorhynchus anatinus	92.00	0.00e+00	1373.00
IUUC-Ocu-074787	Oryctolagus cuniculus	97.40	0.00e+00	1488.00
IUUC-Ola-086737	Oryzias latipes	33.48	4.00e-28	120.00
IUUC-Oga-088764	Otolemur garnettii	95.47	0.00e+00	1467.00
IUUC-Oar-090333	Ovis aries	97.81	0.00e+00	1495.00
IUUC-Ptr-090568	Pan troglodytes	97.12	0.00e+00	1489.00
IUUC-Pan-091979	Papio anubis	97.40	0.00e+00	1488.00
IUUC-Psi-093336	Pelodiscus sinensis	87.65	0.00e+00	1350.00
IUUC-Pma-094200	Petromyzon marinus	44.48	2.00e-177	615.00
IUUC-Pfo-096354	Poecilia formosa	71.55	0.00e+00	1078.00
IUUC-Pab-098499	Pongo abelii	97.53	0.00e+00	1493.00
IUUC-Pva-102454	Pteropus vampyrus	96.16	0.00e+00	1454.00
IUUC-Rno-105595	Rattus norvegicus	94.51	0.00e+00	1431.00
IUUC-Sha-106864	Sarcophilus harrisii	93.72	0.00e+00	1451.00
IUUC-Sar-113728	Sorex araneus	89.14	0.00e+00	1280.00
IUUC-Tgu-117200	Taeniopygia guttata	86.20	0.00e+00	1348.00
IUUC-Tsy-119017	Tarsius syrichta	96.14	0.00e+00	1096.00
IUUC-Tni-120724	Tetraodon nigroviridis	70.80	0.00e+00	1072.00
IUUC-Tbe-127887	Tupaia belangeri	87.37	0.00e+00	1043.00
IUUC-Ttr-129111	Tursiops truncatus	90.40	0.00e+00	1362.00
IUUC-Vpa-130724	Vicugna pacos	98.77	0.00e+00	1507.00
IUUC-Xtr-132091	Xenopus tropicalis	74.42	0.00e+00	1164.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence