iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132360

Ensembl Protein ID

ENSXETP00000013582.3

UniProt Accession

F7DYP1; F7DYP1_XENTR

Genbank Protein ID

ENSXETP00000013582

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01079355

Gene Name

FRK; frk

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000006166.3	ENSXETT00000013582.3	ENSXETP00000013582.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-12	46.7	77	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk..elegkrGlfPenFvekle 63
            +   +ly+ye+ + deL++k+Gd++l+i  +++ + W+k++   +  + +G +P n+v+ ++
   Q: 77   RNSYVALYSYEGRTPDELSFKAGDQMLII--DTTHASWWKAKLlrTRGKAEGYVPFNYVAPVS 137
           567789***********************..9999******7774555679********9986 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

CYSCTRGIAE KLISEMGNCC RKNCSCLSCV LPCVFKEEKR SGSNSFNGIV IQNPVITTQL 60
DGPQVPPRFV NQGEQQRNSY VALYSYEGRT PDELSFKAGD QMLIIDTTHA SWWKAKLLRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTATAGCT GTACCAGAGG AATTGCTGAA AAATTAATCT CAGAGATGGG GAATTGTTGT 60
AGGAAAAATT GCAGCTGCTT AAGCTGTGTG CTTCCCTGTG TCTTTAAAGA AGAGAAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000727	Aegilops tauschii	29.23	7.00e-22	99.40
IUUC-Atr-002967	Amborella trichopoda	30.57	2.00e-22	100.00
IUUC-Apl-003394	Anas platyrhynchos	57.06	5.00e-178	617.00
IUUC-Aca-004553	Anolis carolinensis	58.85	0.00e+00	654.00
IUUC-Cja-019885	Callithrix jacchus	59.43	0.00e+00	657.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	28.87	6.00e-21	94.70
IUUC-Cin-025605	Ciona intestinalis	51.80	2.00e-152	531.00
IUUC-Dre-028274	Danio rerio	55.47	7.00e-167	580.00
IUUC-Dno-029689	Dasypus novemcinctus	59.23	0.00e+00	647.00
IUUC-Dme-031976	Drosophila melanogaster	58.10	6.00e-165	573.00
IUUC-Eeu-034770	Erinaceus europaeus	46.27	8.00e-121	426.00
IUUC-Fal-036892	Ficedula albicollis	56.39	4.00e-176	610.00
IUUC-Gga-041072	Gallus gallus	58.96	3.00e-179	620.00
IUUC-Gma-043806	Glycine max	28.32	3.00e-24	107.00
IUUC-Hvu-047815	Hordeum vulgare	28.99	6.00e-20	92.80
IUUC-Loc-052913	Lepisosteus oculatus	55.53	6.00e-168	583.00
IUUC-Mtr-058733	Medicago truncatula	29.37	1.00e-24	108.00
IUUC-Mga-059456	Meleagris gallopavo	59.03	6.00e-179	620.00
IUUC-Mmr-061480	Microcebus murinus	59.20	0.00e+00	639.00
IUUC-Mlu-067167	Myotis lucifugus	58.11	4.00e-177	613.00
IUUC-Nle-069786	Nomascus leucogenys	59.25	0.00e+00	659.00
IUUC-Ont-072417	Oreochromis niloticus	60.39	2.00e-168	585.00
IUUC-Opu-083905	Oryza punctata	30.68	8.00e-21	95.90
IUUC-Ola-086419	Oryzias latipes	59.05	2.00e-164	572.00
IUUC-Pan-092732	Papio anubis	59.06	0.00e+00	652.00
IUUC-Psi-093899	Pelodiscus sinensis	61.39	0.00e+00	675.00
IUUC-Pma-094230	Petromyzon marinus	55.89	7.00e-158	550.00
IUUC-Pfo-096035	Poecilia formosa	53.25	1.00e-157	549.00
IUUC-Rno-105269	Rattus norvegicus	58.49	0.00e+00	643.00
IUUC-Tgu-116491	Taeniopygia guttata	62.45	6.00e-176	610.00
IUUC-Tni-120512	Tetraodon nigroviridis	53.64	1.00e-165	575.00
IUUC-Tae-123310	Triticum aestivum	29.23	4.00e-22	99.80
IUUC-Tur-126643	Triticum urartu	29.51	2.00e-22	100.00
IUUC-Ttr-128817	Tursiops truncatus	59.06	0.00e+00	652.00
IUUC-Vpa-130389	Vicugna pacos	56.44	6.00e-173	600.00
IUUC-Vvi-131372	Vitis vinifera	27.76	1.00e-23	104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence