iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107201

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01077924

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000000187.1	ENSSHAT00000000224.1	ENSSHAP00000000220.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.40e-13	49.9	106	153

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l++ ++r+Lq+LCR++I+ ++g+++l    k+PL+++LkdYL+++++q
   Q: 106  VTPLRQLRVRPLQELCRKSIVATFGRDNL---GKIPLNPVLKDYLKSFPFQ 153
           56789999*********************...****************986 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

FRSQADYFSI TRASALLDAC GFYWGPLSVN VAHEKLKDEP VGTFLVRDSR QKNCFFAISV 60
KMASGPTSIR VNFQAGRFNL DGSRETFDCL FKLLEHYLNS PRKMLVTPLR QLRVRPLQEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCGCTCCC AAGCGGACTA CTTCAGCATC ACCCGAGCCA GCGCCTTGCT GGACGCCTGT 60
GGCTTCTACT GGGGGCCGCT GAGTGTGAAC GTGGCCCATG AGAAACTCAA GGATGAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	74.03	8.00e-64	235.00
IUUC-Apl-003313	Anas platyrhynchos	83.77	1.00e-76	278.00
IUUC-Aca-005109	Anolis carolinensis	67.10	4.00e-62	230.00
IUUC-Ame-011550	Astyanax mexicanus	53.55	4.00e-50	190.00
IUUC-Bta-013411	Bos taurus	80.52	1.00e-73	268.00
IUUC-Cja-019595	Callithrix jacchus	81.17	5.00e-74	270.00
IUUC-Cfa-020563	Canis familiaris	79.87	4.00e-73	266.00
IUUC-Cpo-021374	Cavia porcellus	80.52	1.00e-73	268.00
IUUC-Csa-023333	Chlorocebus sabaeus	81.82	1.00e-74	271.00
IUUC-Dre-028507	Danio rerio	50.68	5.00e-43	166.00
IUUC-Dno-029406	Dasypus novemcinctus	81.82	6.00e-74	269.00
IUUC-Ete-032399	Echinops telfairi	79.87	1.00e-72	265.00
IUUC-Eca-033519	Equus caballus	80.52	1.00e-71	261.00
IUUC-Fal-036726	Ficedula albicollis	83.77	5.00e-77	280.00
IUUC-Gmo-039667	Gadus morhua	43.36	1.00e-23	102.00
IUUC-Gga-040970	Gallus gallus	83.77	1.00e-76	278.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.87	5.00e-34	136.00
IUUC-Ggo-045569	Gorilla gorilla	81.17	2.00e-74	270.00
IUUC-Hsa-046010	Homo sapiens	81.17	5.00e-74	270.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	81.17	6.00e-74	270.00
IUUC-Lch-050219	Latimeria chalumnae	64.47	2.00e-59	221.00
IUUC-Loc-052494	Lepisosteus oculatus	62.34	3.00e-57	214.00
IUUC-Laf-054219	Loxodonta africana	78.68	5.00e-61	226.00
IUUC-Mcc-054830	Macaca mulatta	81.82	1.00e-74	271.00
IUUC-Meu-056565	Macropus eugenii	98.70	4.00e-88	316.00
IUUC-Mga-060153	Meleagris gallopavo	83.12	9.00e-76	275.00
IUUC-Mmr-061365	Microcebus murinus	81.17	6.00e-74	270.00
IUUC-Mdo-062824	Monodelphis domestica	99.35	3.00e-88	317.00
IUUC-Mmu-064120	Mus musculus	79.87	5.00e-73	266.00
IUUC-Mpu-066839	Mustela putorius furo	81.17	4.00e-74	270.00
IUUC-Mlu-067829	Myotis lucifugus	79.87	4.00e-73	266.00
IUUC-Nle-069592	Nomascus leucogenys	79.22	2.00e-71	261.00
IUUC-Ont-072173	Oreochromis niloticus	44.52	3.00e-36	144.00
IUUC-Ocu-073996	Oryctolagus cuniculus	81.17	8.00e-74	269.00
IUUC-Ola-087158	Oryzias latipes	45.81	4.00e-37	147.00
IUUC-Oga-088076	Otolemur garnettii	81.17	5.00e-74	270.00
IUUC-Ptr-091241	Pan troglodytes	81.17	4.00e-74	270.00
IUUC-Pan-091836	Papio anubis	81.82	9.00e-75	272.00
IUUC-Psi-093628	Pelodiscus sinensis	84.42	6.00e-77	279.00
IUUC-Pfo-097501	Poecilia formosa	41.56	2.00e-33	135.00
IUUC-Pab-098170	Pongo abelii	81.17	5.00e-74	270.00
IUUC-Pop-100072	Populus trichocarpa	33.33	1.30e-02	33.50
IUUC-Pva-102796	Pteropus vampyrus	80.52	1.00e-73	268.00
IUUC-Rno-105319	Rattus norvegicus	79.87	5.00e-73	266.00
IUUC-Ssc-116004	Sus scrofa	81.17	4.00e-74	270.00
IUUC-Tgu-116836	Taeniopygia guttata	82.47	3.00e-75	273.00
IUUC-Tru-118090	Takifugu rubripes	42.58	6.00e-34	136.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.87	3.00e-30	124.00
IUUC-Vpa-130235	Vicugna pacos	81.17	5.00e-74	270.00
IUUC-Xtr-132610	Xenopus tropicalis	72.08	5.00e-67	246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence