iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066014

Ensembl Protein ID

ENSMPUP00000012896.1

UniProt Accession

M3YNI9; M3YNI9_MUSPF

Genbank Protein ID

ENSMPUP00000012896

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01030266

Gene Name

USP47

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000012995.1	ENSMPUT00000013105.1	ENSMPUP00000012896.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.60e-76	255.3	174	548

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    +++e++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q
   Q: 174  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEESE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQ 256
           6******************************...5555443.5899*********************************9998..9*** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +D+qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++ 
   Q: 257  HDVQELCRVMFDALEQKW--------------------------KQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRP 319
           ******************..........................678999*************************************95 PP
   S: 179  ke.etkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
              +++  s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f  
   Q: 320  YGsSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFID 408
           54045678******************************************************************************999 PP
   S: 267  speekqke.....................................................kkkYeLiavvvHsGslssGHYvayvkne 302
            ++ek+ +                                                     + +YeL++v+vHsGs+ +GHY+a++k+ 
   Q: 409  VEDEKSPQtesctdsgaenegschsdqmsndfsnddgvdegiclesnsgtekiskpgleknSLIYELFSVMVHSGSAAGGHYYACIKSF 497
           9777766678888888999999999999999999999999999999999999999999999***************************6 PP
   S: 303  kgk.WllfdDskVtevkeeevleetg................staYvlfYk 336
           +++ W+ f+D++V+ +++e++++++g                ++aY+l+Y+
   Q: 498  SDEqWYSFNDQHVSRITQEDIKKTHGgssgsrgyyssafassTNAYMLIYR 548
           5555*******************888************************8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLAESLLAYL LHFYTDNTQI ENAAEEPRVL CIIQDTTNSK TVNERITLNL PASTPLRKLF 60
EDVANKVGYI NGTFDLVWGN GINTADMAPL DHTSDKSLLD ASFEPGKKNF LHLTDKDGEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGAAATGT TTCCCATCAT AATGCATCGT AAGTGCATTT CCCACATGTG AGTCATGCTG 60
GCAGAATCTC TTTTGGCATA CTTGTTACAT TTTTATACGG ATAACACACA GGTAGGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006284--P:base-excision repair
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002228	Ailuropoda melanoleuca	97.77	0.00e+00	2543.00
IUUC-Apl-003486	Anas platyrhynchos	90.48	0.00e+00	2335.00
IUUC-Aca-005061	Anolis carolinensis	88.10	0.00e+00	2373.00
IUUC-Ame-011206	Astyanax mexicanus	80.98	0.00e+00	2095.00
IUUC-Bta-012942	Bos taurus	98.06	0.00e+00	2546.00
IUUC-Cel-018600	Caenorhabditis elegans	50.00	5.00e-120	426.00
IUUC-Cja-018950	Callithrix jacchus	98.51	0.00e+00	2395.00
IUUC-Cfa-020299	Canis familiaris	99.48	0.00e+00	2600.00
IUUC-Cpo-021943	Cavia porcellus	97.62	0.00e+00	2511.00
IUUC-Csa-023285	Chlorocebus sabaeus	98.44	0.00e+00	2533.00
IUUC-Cho-025006	Choloepus hoffmanni	89.72	0.00e+00	2207.00
IUUC-Cin-025145	Ciona intestinalis	42.10	0.00e+00	731.00
IUUC-Csv-025839	Ciona savignyi	50.23	2.00e-166	580.00
IUUC-Dre-027959	Danio rerio	81.39	0.00e+00	2038.00
IUUC-Dno-030023	Dasypus novemcinctus	95.69	0.00e+00	2404.00
IUUC-Dor-030994	Dipodomys ordii	97.72	0.00e+00	964.00
IUUC-Dme-031604	Drosophila melanogaster	49.05	2.00e-145	510.00
IUUC-Ete-032596	Echinops telfairi	81.19	0.00e+00	1309.00
IUUC-Eca-033913	Equus caballus	98.44	0.00e+00	2552.00
IUUC-Eeu-034518	Erinaceus europaeus	89.95	0.00e+00	2169.00
IUUC-Fca-035997	Felis catus	99.26	0.00e+00	2590.00
IUUC-Fal-037088	Ficedula albicollis	89.81	0.00e+00	2113.00
IUUC-Gmo-038920	Gadus morhua	77.66	0.00e+00	1979.00
IUUC-Gga-040953	Gallus gallus	89.52	0.00e+00	2328.00
IUUC-Gac-042400	Gasterosteus aculeatus	79.68	0.00e+00	2023.00
IUUC-Ggo-044820	Gorilla gorilla	95.76	0.00e+00	2489.00
IUUC-Hsa-046634	Homo sapiens	98.36	0.00e+00	2529.00
IUUC-Lch-050440	Latimeria chalumnae	86.60	0.00e+00	2261.00
IUUC-Loc-051904	Lepisosteus oculatus	84.96	0.00e+00	2206.00
IUUC-Laf-053760	Loxodonta africana	97.10	0.00e+00	2547.00
IUUC-Mcc-054637	Macaca mulatta	98.51	0.00e+00	2535.00
IUUC-Meu-056904	Macropus eugenii	95.60	0.00e+00	1697.00
IUUC-Mga-059556	Meleagris gallopavo	88.85	0.00e+00	2313.00
IUUC-Mmr-061192	Microcebus murinus	98.81	0.00e+00	2541.00
IUUC-Mdo-061929	Monodelphis domestica	95.76	0.00e+00	2508.00
IUUC-Mmu-063726	Mus musculus	94.57	0.00e+00	2508.00
IUUC-Mlu-067232	Myotis lucifugus	98.07	0.00e+00	2520.00
IUUC-Nle-069619	Nomascus leucogenys	98.29	0.00e+00	2528.00
IUUC-Opr-070224	Ochotona princeps	93.27	0.00e+00	1143.00
IUUC-Ont-071384	Oreochromis niloticus	81.09	0.00e+00	2054.00
IUUC-Oan-073208	Ornithorhynchus anatinus	89.18	0.00e+00	2392.00
IUUC-Ocu-074285	Oryctolagus cuniculus	98.21	0.00e+00	2529.00
IUUC-Ola-087051	Oryzias latipes	79.50	0.00e+00	1981.00
IUUC-Oga-088928	Otolemur garnettii	98.14	0.00e+00	2530.00
IUUC-Oar-090215	Ovis aries	98.37	0.00e+00	2553.00
IUUC-Ptr-091035	Pan troglodytes	98.36	0.00e+00	2530.00
IUUC-Pan-092377	Papio anubis	97.99	0.00e+00	2511.00
IUUC-Pfo-096722	Poecilia formosa	80.60	0.00e+00	2049.00
IUUC-Pab-098723	Pongo abelii	98.29	0.00e+00	2531.00
IUUC-Pca-100105	Procavia capensis	93.00	0.00e+00	2325.00
IUUC-Pva-102514	Pteropus vampyrus	99.13	0.00e+00	926.00
IUUC-Rno-105384	Rattus norvegicus	95.68	0.00e+00	2451.00
IUUC-Sha-106982	Sarcophilus harrisii	93.67	0.00e+00	2509.00
IUUC-Sar-113723	Sorex araneus	87.08	0.00e+00	937.00
IUUC-Ssc-115671	Sus scrofa	98.43	0.00e+00	2056.00
IUUC-Tgu-116722	Taeniopygia guttata	88.41	0.00e+00	2310.00
IUUC-Tru-118380	Takifugu rubripes	78.37	0.00e+00	2049.00
IUUC-Tsy-119646	Tarsius syrichta	91.73	0.00e+00	2315.00
IUUC-Tni-120762	Tetraodon nigroviridis	78.59	0.00e+00	2073.00
IUUC-Tbe-127861	Tupaia belangeri	95.61	0.00e+00	2375.00
IUUC-Ttr-129254	Tursiops truncatus	92.75	0.00e+00	1468.00
IUUC-Vpa-130141	Vicugna pacos	99.18	0.00e+00	1159.00
IUUC-Xtr-132700	Xenopus tropicalis	82.17	0.00e+00	2199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence