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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104853
Ensembl Protein ID ENSRNOP00000071286.1
UniProt Accession P63331; O88591; P13353; PP2AA_RAT
Genbank Protein ID CAA34166.1; CAB42983.1; AAA41904.1; AAH70914.1; AAH72531.1
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Genbank Nucleotide ID X16043; X14159; M33114; BC070914; BC072531
Gene Name LOC103694903; Ppp2ca
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000056485.1 ENSRNOT00000079985.1 ENSRNOP00000071286.1
Annotation
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UIM 99.68 0.00e+00 648.00 IUUC-Hsa-046871
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
 PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
Protein Sequence
(Fasta)
MDEKLFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60
QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104853|UBD,UIM|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
ATGGACGAGA AGTTGTTCAC CAAGGAGCTG GACCAGTGGA TCGAGCAGCT GAACGAGTGC 60
AAGCAGCTCT CCGAGTCCCA GGTCAAGAGC CTCTGCGAGA AGGTGAGCTG CTCTAGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104853|UBD,UIM|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0464--Manganese
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR004843--Calcineurin-like_PHP_ApaH
IPR029052--Metallo-depent_PP-like
IPR006186--Ser/Thr-sp_prot-phosphatase
PROSITE

PS00125--SER_THR_PHOSPHATASE
Pfam

PF00149--Metallophos
PRINTS

PR00114--STPHPHTASE
SMART

SM00156--PP2Ac
Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0014069--C:postsynaptic density
GO:0000922--C:spindle pole
GO:0043195--C:terminal bouton
GO:0019899--F:enzyme binding
GO:0044325--F:ion channel binding
GO:0046872--F:metal ion binding
GO:1990405--F:protein antigen binding
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0046983--F:protein dimerization activity
GO:0019904--F:protein domain specific binding
GO:0046982--F:protein heterodimerization activity
GO:0043422--F:protein kinase B binding
GO:0019901--F:protein kinase binding
GO:0051721--F:protein phosphatase 2A binding
GO:0019903--F:protein phosphatase binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0048156--F:tau protein binding
GO:0003231--P:cardiac ventricle development
GO:0071277--P:cellular response to calcium ion
GO:0071345--P:cellular response to cytokine stimulus
GO:0071361--P:cellular response to ethanol
GO:0071372--P:cellular response to follicle-stimulating hormone stimulus
GO:0071333--P:cellular response to glucose stimulus
GO:0032869--P:cellular response to insulin stimulus
GO:0071383--P:cellular response to steroid hormone stimulus
GO:0007507--P:heart development
GO:0051321--P:meiotic cell cycle
GO:1901020--P:negative regulation of calcium ion transmembrane transporter activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:0042992--P:negative regulation of transcription factor import into nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043065--P:positive regulation of apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0032516--P:positive regulation of phosphoprotein phosphatase activity
GO:0035307--P:positive regulation of protein dephosphorylation
GO:0006470--P:protein dephosphorylation
GO:0070208--P:protein heterotrimerization
GO:0031952--P:regulation of protein autophosphorylation
GO:0042176--P:regulation of protein catabolic process
GO:0001932--P:regulation of protein phosphorylation
GO:0010469--P:regulation of receptor activity
KEGG rno:103694903; rno:24672
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000073 Aegilops tauschii 81.40 1.00e-153 535.00
IUUC-Aml-001862 Ailuropoda melanoleuca 99.68 0.00e+00 648.00
IUUC-Atr-002565 Amborella trichopoda 82.39 4.00e-155 540.00
IUUC-Apl-004163 Anas platyrhynchos 97.10 0.00e+00 632.00
IUUC-Aca-005038 Anolis carolinensis 98.71 0.00e+00 644.00
IUUC-Aly-005921 Arabidopsis lyrata 80.20 9.00e-154 535.00
IUUC-Ath-007164 Arabidopsis thaliana 80.20 2.00e-153 535.00
IUUC-Ame-010907 Astyanax mexicanus 99.03 0.00e+00 644.00
IUUC-Bgr-012186 Blumeria graminis 84.04 9.00e-159 552.00
IUUC-Bta-013583 Bos taurus 99.68 0.00e+00 648.00
IUUC-Bci-013884 Botrytis cinerea 85.02 1.00e-160 558.00
IUUC-Bdi-014993 Brachypodium distachyon 81.40 1.00e-153 535.00
IUUC-Bra-017702 Brassica rapa 80.20 2.00e-154 538.00
IUUC-Cja-019549 Callithrix jacchus 99.68 0.00e+00 648.00
IUUC-Cfa-020295 Canis familiaris 99.68 0.00e+00 648.00
IUUC-Cpo-022311 Cavia porcellus 99.68 0.00e+00 648.00
IUUC-Cre-022625 Chlamydomonas reinhardtii 78.43 8.00e-148 516.00
IUUC-Csa-023283 Chlorocebus sabaeus 99.68 0.00e+00 648.00
IUUC-Cin-025581 Ciona intestinalis 93.07 1.00e-173 602.00
IUUC-Csv-026026 Ciona savignyi 91.91 8.00e-152 529.00
IUUC-Cgl-026758 Colletotrichum gloeosporioides 84.69 1.00e-160 558.00
IUUC-Cne-026997 Cryptococcus neoformans 85.38 2.00e-160 558.00
IUUC-Cme-027101 Cyanidioschyzon merolae 82.52 4.00e-158 550.00
IUUC-Dre-027487 Danio rerio 97.41 0.00e+00 639.00
IUUC-Dno-028872 Dasypus novemcinctus 99.68 0.00e+00 648.00
IUUC-Ete-032859 Echinops telfairi 99.68 0.00e+00 648.00
IUUC-Fca-036395 Felis catus 99.68 0.00e+00 648.00
IUUC-Fal-036826 Ficedula albicollis 100.00 1.00e-166 578.00
IUUC-Fox-037783 Fusarium oxysporum 86.00 5.00e-161 560.00
IUUC-Fso-038215 Fusarium solani 84.69 5.00e-161 560.00
IUUC-Gmo-038520 Gadus morhua 96.43 1.00e-179 622.00
IUUC-Ggr-039745 Gaeumannomyces graminis 84.69 2.00e-160 557.00
IUUC-Gga-040663 Gallus gallus 98.71 0.00e+00 644.00
IUUC-Gac-042221 Gasterosteus aculeatus 96.76 0.00e+00 633.00
IUUC-Gma-042753 Glycine max 81.73 3.00e-154 537.00
IUUC-Ggo-044960 Gorilla gorilla 99.68 0.00e+00 648.00
IUUC-Hsa-046871 Homo sapiens 99.68 0.00e+00 648.00
IUUC-Itr-048646 Ictidomys tridecemlineatus 99.68 0.00e+00 648.00
IUUC-Kpa-049311 Komagataella pastoris 76.49 1.00e-143 502.00
IUUC-Lch-050295 Latimeria chalumnae 99.03 0.00e+00 645.00
IUUC-Lpe-051261 Leersia perrieri 81.40 8.00e-155 539.00
IUUC-Loc-052336 Lepisosteus oculatus 99.35 0.00e+00 646.00
IUUC-Lma-053211 Leptosphaeria maculans 86.33 4.00e-161 560.00
IUUC-Laf-053835 Loxodonta africana 99.68 0.00e+00 648.00
IUUC-Mcc-055756 Macaca mulatta 99.68 0.00e+00 648.00
IUUC-Meu-056068 Macropus eugenii 75.08 8.00e-130 456.00
IUUC-Mor-057272 Magnaporthe oryzae 84.69 1.00e-160 558.00
IUUC-Mpo-057478 Magnaporthe poae 84.69 2.00e-160 558.00
IUUC-Mtr-057736 Medicago truncatula 80.40 4.00e-152 530.00
IUUC-Mla-059001 Melampsora laricipopulina 85.15 2.00e-161 561.00
IUUC-Mga-059904 Meleagris gallopavo 97.24 3.00e-170 590.00
IUUC-Mvi-060467 Microbotryum violaceum 85.86 6.00e-162 563.00
IUUC-Mmr-060867 Microcebus murinus 99.68 0.00e+00 648.00
IUUC-Mdo-062353 Monodelphis domestica 99.68 0.00e+00 648.00
IUUC-Mmu-064204 Mus musculus 100.00 0.00e+00 649.00
IUUC-Mac-064924 Musa acuminata 82.72 7.00e-156 542.00
IUUC-Mpu-066183 Mustela putorius furo 99.68 0.00e+00 648.00
IUUC-Mlu-067115 Myotis lucifugus 99.35 0.00e+00 645.00
IUUC-Ncr-068958 Neurospora crassa 86.67 4.00e-161 560.00
IUUC-Nle-069365 Nomascus leucogenys 99.68 0.00e+00 648.00
IUUC-Opr-071012 Ochotona princeps 99.68 0.00e+00 648.00
IUUC-Ont-071469 Oreochromis niloticus 97.09 0.00e+00 634.00
IUUC-Oan-072869 Ornithorhynchus anatinus 95.55 1.00e-167 581.00
IUUC-Ocu-074394 Oryctolagus cuniculus 99.68 0.00e+00 648.00
IUUC-Oba-075432 Oryza barthii 81.06 6.00e-154 536.00
IUUC-Ogl-077436 Oryza glaberrima 82.39 1.00e-154 538.00
IUUC-Ogu-078351 Oryza glumaepatula 81.06 6.00e-154 536.00
IUUC-Oin-080218 Oryza indica 82.39 2.00e-154 538.00
IUUC-Olo-080223 Oryza longistaminata 82.39 1.00e-154 538.00
IUUC-Ome-081581 Oryza meridionalis 82.39 2.00e-154 538.00
IUUC-Oni-082094 Oryza nivara 82.39 2.00e-154 538.00
IUUC-Opu-083544 Oryza punctata 82.06 1.00e-154 538.00
IUUC-Oru-084975 Oryza rufipogon 82.39 2.00e-154 538.00
IUUC-Osa-085945 Oryza sativa 82.39 2.00e-154 538.00
IUUC-Ola-087141 Oryzias latipes 96.76 0.00e+00 633.00
IUUC-Oga-087919 Otolemur garnettii 99.68 0.00e+00 648.00
IUUC-Oar-089240 Ovis aries 100.00 1.00e-166 578.00
IUUC-Ptr-091367 Pan troglodytes 99.03 0.00e+00 641.00
IUUC-Pan-091956 Papio anubis 99.68 0.00e+00 648.00
IUUC-Psi-094099 Pelodiscus sinensis 98.05 0.00e+00 630.00
IUUC-Pma-094369 Petromyzon marinus 90.70 5.00e-89 319.00
IUUC-Pno-094872 Phaeosphaeria nodorum 78.00 9.00e-138 482.00
IUUC-Ppa-095520 Physcomitrella patens 84.05 1.00e-158 552.00
IUUC-Pfo-097359 Poecilia formosa 97.41 0.00e+00 635.00
IUUC-Pop-099210 Populus trichocarpa 81.73 1.00e-154 538.00
IUUC-Pca-100122 Procavia capensis 86.41 1.00e-154 538.00
IUUC-Ppe-101822 Prunus persica 81.40 2.00e-153 535.00
IUUC-Pva-102237 Pteropus vampyrus 89.32 4.00e-163 566.00
IUUC-Pgr-103259 Puccinia graminis 84.49 2.00e-160 557.00
IUUC-Pte-104116 Pyrenophora teres 86.33 6.00e-161 559.00
IUUC-Pyt-104768 Pyrenophora triticirepentis 86.33 6.00e-161 559.00
IUUC-Sce-106338 Saccharomyces cerevisiae 76.16 1.00e-144 506.00
IUUC-Sha-107562 Sarcophilus harrisii 99.68 0.00e+00 649.00
IUUC-Sja-107705 Schizosaccharomyces japonicus 81.40 5.00e-154 536.00
IUUC-Spo-108240 Schizosaccharomyces pombe 80.07 3.00e-152 530.00
IUUC-Smo-109421 Selaginella moellendorffii 84.44 1.00e-158 551.00
IUUC-Sit-110313 Setaria italica 81.73 1.00e-154 538.00
IUUC-Sly-111492 Solanum lycopersicum 82.06 1.00e-154 538.00
IUUC-Stu-112108 Solanum tuberosum 82.06 1.00e-154 538.00
IUUC-Sar-113253 Sorex araneus 94.79 5.00e-174 603.00
IUUC-Sbi-114125 Sorghum bicolor 81.40 9.00e-154 535.00
IUUC-Sre-115054 Sporisorium reilianum 86.38 2.00e-161 561.00
IUUC-Tgu-117419 Taeniopygia guttata 98.71 0.00e+00 644.00
IUUC-Tru-117531 Takifugu rubripes 96.76 0.00e+00 632.00
IUUC-Tsy-119543 Tarsius syrichta 99.68 0.00e+00 648.00
IUUC-Tni-120904 Tetraodon nigroviridis 96.44 0.00e+00 630.00
IUUC-Tca-120941 Theobroma cacao 82.45 8.00e-155 539.00
IUUC-Tre-121939 Trichoderma reesei 84.67 5.00e-158 550.00
IUUC-Tvi-122516 Trichoderma virens 84.67 1.00e-158 551.00
IUUC-Tae-124897 Triticum aestivum 81.40 1.00e-153 535.00
IUUC-Tbe-127639 Tupaia belangeri 99.68 0.00e+00 648.00
IUUC-Ttr-128718 Tursiops truncatus 99.35 0.00e+00 647.00
IUUC-Uma-129470 Ustilago maydis 86.38 2.00e-161 561.00
IUUC-Vvi-131390 Vitis vinifera 81.73 4.00e-154 536.00
IUUC-Xtr-132784 Xenopus tropicalis 99.03 0.00e+00 644.00
IUUC-Xma-133450 Xiphophorus maculatus 96.44 0.00e+00 630.00
Created Date 25-Jun-2017

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