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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063170
UUCD1 version UUC-MuM-00292
Ensembl Protein ID ENSMUSP00000096248.4
UniProt Accession O88907; Q8C6H5; PIAS1_MOUSE
Genbank Protein ID AAC36701.1; BAC35902.1; AAH51417.1
Protein Name E3 SUMO-protein ligase PIAS1; DEAD/H box-binding protein 1; Protein inhibitor of activated STAT protein 1; RING-type E3 ubiquitin transferase PIAS1
Genbank Nucleotide ID AF077950; AK075708; BC051417
Gene Name Pias1; Ddxbp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032405.10 ENSMUST00000098651.5 ENSMUSP00000096248.4
ENSMUSG00000032405.10 ENSMUST00000215501.1 ENSMUSP00000149235.1
ENSMUSG00000032405.10 ENSMUST00000214830.1 ENSMUSP00000150834.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 98.00 0.00e+00 1152.00 IUUC-Hsa-046146
E3 activity/RING/RING 28.61 6.00e-28 120.00 IUUC-Spo-108339
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).
 Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).
Protein Sequence
(Fasta)
MADSAELKQM VMSLRVSELQ VLLGYAGRNK HGRKHELLTK ALHLLKAGCS PAVQMKIKEL 60
YRRRFPQKIM TPADLSIPNV HSSPMPPTLS PSTIPQLTYD GHPASSPLLP VSLLGPKHEL 120
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Protein Fasta Sequence


>IUUC-Mmu-063170|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GGCAGTGAGG GAAGGAGGAC AAGGAGACAG AGGATGAAGA AGAGGATGAG GACAAGGACA 60
AGGAAATGAG TAAGTATCAG ATCTTGAAGT CTTTGCCTCA AAGTGACACA TAGAATCTCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063170|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027227--PIAS1
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ
PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING
Pfam

PF14324--PINIT
PF02891--zf-MIZ
SMART

SM00513--SAP
Gene Ontology

GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0019899--F:enzyme binding
GO:0061665--F:SUMO ligase activity
GO:0019789--F:SUMO transferase activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0045444--P:fat cell differentiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235--P:positive regulation of protein sumoylation
GO:0051152--P:positive regulation of smooth muscle cell differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0016925--P:protein sumoylation
GO:0065004--P:protein-DNA complex assembly
GO:0042127--P:regulation of cell proliferation
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning
KEGG mmu:56469
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001984 Ailuropoda melanoleuca 98.14 0.00e+00 1172.00
IUUC-Apl-003376 Anas platyrhynchos 94.01 0.00e+00 1177.00
IUUC-Aca-004444 Anolis carolinensis 85.80 0.00e+00 1080.00
IUUC-Aly-006507 Arabidopsis lyrata 35.48 2.00e-14 75.10
IUUC-Ame-011812 Astyanax mexicanus 74.96 0.00e+00 811.00
IUUC-Bta-012457 Bos taurus 98.16 0.00e+00 1187.00
IUUC-Bci-013700 Botrytis cinerea 29.49 1.00e-29 124.00
IUUC-Bol-015250 Brassica oleracea 27.75 2.00e-17 84.70
IUUC-Cel-018231 Caenorhabditis elegans 37.26 4.00e-50 193.00
IUUC-Cfa-020481 Canis familiaris 98.31 0.00e+00 1176.00
IUUC-Cpo-021940 Cavia porcellus 98.16 0.00e+00 1203.00
IUUC-Csa-023964 Chlorocebus sabaeus 98.00 0.00e+00 1174.00
IUUC-Cho-024812 Choloepus hoffmanni 80.57 0.00e+00 718.00
IUUC-Csv-026329 Ciona savignyi 38.51 1.00e-78 287.00
IUUC-Cne-026824 Cryptococcus neoformans 40.37 1.00e-19 91.70
IUUC-Cme-027209 Cyanidioschyzon merolae 33.33 5.00e-15 76.60
IUUC-Dre-027526 Danio rerio 76.43 0.00e+00 891.00
IUUC-Dno-029550 Dasypus novemcinctus 97.98 0.00e+00 1174.00
IUUC-Dor-030325 Dipodomys ordii 83.20 0.00e+00 715.00
IUUC-Dme-032018 Drosophila melanogaster 47.41 6.00e-102 365.00
IUUC-Ete-032366 Echinops telfairi 85.63 0.00e+00 680.00
IUUC-Eca-033639 Equus caballus 98.29 0.00e+00 1162.00
IUUC-Eeu-034994 Erinaceus europaeus 85.64 0.00e+00 666.00
IUUC-Fca-035986 Felis catus 98.14 0.00e+00 1159.00
IUUC-Fal-036926 Ficedula albicollis 94.30 0.00e+00 1117.00
IUUC-Fso-038103 Fusarium solani 33.95 2.00e-26 113.00
IUUC-Gmo-039058 Gadus morhua 73.14 0.00e+00 827.00
IUUC-Gga-040755 Gallus gallus 93.87 0.00e+00 1180.00
IUUC-Gac-042204 Gasterosteus aculeatus 72.13 0.00e+00 840.00
IUUC-Ggo-044494 Gorilla gorilla 95.34 0.00e+00 1123.00
IUUC-Hsa-046146 Homo sapiens 98.00 0.00e+00 1174.00
IUUC-Itr-048994 Ictidomys tridecemlineatus 97.83 0.00e+00 1157.00
IUUC-Lch-049611 Latimeria chalumnae 84.26 0.00e+00 1034.00
IUUC-Loc-052851 Lepisosteus oculatus 78.00 0.00e+00 855.00
IUUC-Laf-053486 Loxodonta africana 96.12 0.00e+00 1132.00
IUUC-Mcc-055123 Macaca mulatta 98.00 0.00e+00 1174.00
IUUC-Meu-056556 Macropus eugenii 68.20 0.00e+00 749.00
IUUC-Mor-057185 Magnaporthe oryzae 31.86 2.00e-25 110.00
IUUC-Mga-059790 Meleagris gallopavo 95.85 0.00e+00 1054.00
IUUC-Mmr-060785 Microcebus murinus 97.67 0.00e+00 1158.00
IUUC-Mdo-061916 Monodelphis domestica 96.58 0.00e+00 1169.00
IUUC-Mpu-066609 Mustela putorius furo 98.31 0.00e+00 1176.00
IUUC-Mlu-067164 Myotis lucifugus 96.43 0.00e+00 1139.00
IUUC-Ncr-068929 Neurospora crassa 32.72 2.00e-26 114.00
IUUC-Nle-070004 Nomascus leucogenys 98.00 0.00e+00 1174.00
IUUC-Opr-070738 Ochotona princeps 77.60 0.00e+00 806.00
IUUC-Ont-071607 Oreochromis niloticus 76.85 0.00e+00 845.00
IUUC-Oan-073567 Ornithorhynchus anatinus 89.61 0.00e+00 1132.00
IUUC-Ocu-073833 Oryctolagus cuniculus 98.16 0.00e+00 1149.00
IUUC-Ola-086471 Oryzias latipes 72.88 0.00e+00 877.00
IUUC-Olu-087742 Ostreococcus lucimarinus 30.14 1.00e-10 60.80
IUUC-Oga-088527 Otolemur garnettii 96.93 0.00e+00 1144.00
IUUC-Oar-089470 Ovis aries 97.83 0.00e+00 1170.00
IUUC-Ptr-091086 Pan troglodytes 98.00 0.00e+00 1174.00
IUUC-Pan-092236 Papio anubis 98.00 0.00e+00 1174.00
IUUC-Psi-093900 Pelodiscus sinensis 92.86 0.00e+00 1147.00
IUUC-Pma-094693 Petromyzon marinus 65.38 9.00e-177 613.00
IUUC-Pfo-096236 Poecilia formosa 75.98 0.00e+00 867.00
IUUC-Pab-098400 Pongo abelii 98.00 0.00e+00 1173.00
IUUC-Pva-102327 Pteropus vampyrus 89.25 0.00e+00 1038.00
IUUC-Rno-105980 Rattus norvegicus 99.85 0.00e+00 1202.00
IUUC-Spo-108339 Schizosaccharomyces pombe 28.30 3.00e-28 120.00
IUUC-Stu-112120 Solanum tuberosum 36.61 1.00e-17 85.10
IUUC-Sar-113126 Sorex araneus 97.20 0.00e+00 1179.00
IUUC-Sbi-114542 Sorghum bicolor 31.38 7.00e-17 82.40
IUUC-Sre-115069 Sporisorium reilianum 34.21 4.00e-21 97.10
IUUC-Ssc-115394 Sus scrofa 98.55 0.00e+00 1057.00
IUUC-Tgu-117164 Taeniopygia guttata 92.96 0.00e+00 876.00
IUUC-Tru-117960 Takifugu rubripes 76.21 0.00e+00 832.00
IUUC-Tsy-119069 Tarsius syrichta 96.58 0.00e+00 1117.00
IUUC-Tni-120583 Tetraodon nigroviridis 73.64 0.00e+00 823.00
IUUC-Tre-122003 Trichoderma reesei 32.92 5.00e-28 119.00
IUUC-Tbe-127466 Tupaia belangeri 86.21 4.00e-147 515.00
IUUC-Ttr-128717 Tursiops truncatus 91.40 0.00e+00 1044.00
IUUC-Vpa-130624 Vicugna pacos 94.58 0.00e+00 1065.00
IUUC-Vvi-131637 Vitis vinifera 29.32 5.00e-17 83.60
Created Date 25-Jun-2017

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