iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121672

Ensembl Protein ID

EOY34575

UniProt Accession

A0A061GXI7; A0A061GXI7_THECC

Genbank Protein ID

EOY34575.1

Protein Name

Ubiquitin-activating enzyme 1 isoform 1

Genbank Nucleotide ID

CM001887

Gene Name

TCM_042199

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_042199	EOY34575	EOY34575
TCM_042199	EOY34576	EOY34576

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.60e-166	554.4	487	974

Active Site

Position(s)	Description	Evidence
668	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahees 96
           YD Qi ++G++ q+kl+ +kv++vG g+lGcE+lKn +l+Gv     g++t++D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +np+ ++ea +++
   Q: 487  YDAQISVFGSKLQKKLEDSKVFIVGSGALGCEFLKNVALMGVscgsqGKLTITDDDVIEKSNLSRQFLFRDWNIGQAKSTVAASAAASINPQLKIEALQNR 587
           ***************************************************************************************************** PP
   S: 97   iteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.... 190
           + +++e+++   F ++++vV++aldn+ ar++v+++cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa    
   Q: 588  VGPETENVFndtFWENLTVVINALDNVNARLYVDQRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWArsef 688
           *******999****************************************************************************************999 PP
   S: 191  ........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv......... 274
                   + +n +l++  +      +   ++ ++ ++++ + l  e+ e+f++++++a+  f+ ++ n +kql+  f+ d  t+ ++pfw+         
   Q: 689  egllektpAEVNAYLSNPVEYAASMRDAGDAQAKDNLERILECLDREKCETFQDCVAWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSapkrfphpl 789
           99999999666666666666666666677788888888888999999****************************************************** PP
   S: 275  .................................................sfcsnaealqvpekvekdeevvkasap....lylllralerfekk..kgrkp 320
                                                              ++   +++++ek ++  +++    +    +  l+ +le+ +++  +g   
   Q: 790  qfsstdpshlhfimaasilraetfgiavpdqvknpkmlaeaienvivpdFQPKEGVKINTDEKDTSLSTASV---NdeamINELFYKLELCKNNlpSGFRL 887
           *******************99999999998888777777777666666322333333444443333333322...13347666666666666553388889 PP
   S: 321  gelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           + ++fekddd   ++dl++a+an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++Kv++g  k e ++n+f ++a+
   Q: 888  KPIQFEKDDDTnyHMDLIAALANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGahKVEDYRNTFANLAL 974
           99*******************************.**************************************99999******99875 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MLPRKRAGEG EVVEGESENN NNSNNIKDIA VTSPIKKHRF SAAAAADLTA NNNTVAIGNN 60
SSNHSSGSVL EPTIMAPGDA NHNDIDEDLH SRQLAVYGRE TMRLLFASNI LISGMNGLGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGATGTTCG TGACTCAAAA CGACGACGGA TCACCTCAAT CAAAAAAATC TCCCACAATT 60
TGCGTTTCTT TCCATGATTG AATCATTCGC CGTTGGCTTG CAGCCACGGC CCCACGTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	44.98	0.00e+00	875.00
IUUC-Acl-008181	Aspergillus clavatus	45.03	0.00e+00	811.00
IUUC-Afl-008455	Aspergillus flavus	45.98	0.00e+00	811.00
IUUC-Afu-009065	Aspergillus fumigatus	46.22	0.00e+00	840.00
IUUC-Ani-009371	Aspergillus nidulans	46.82	0.00e+00	818.00
IUUC-Ang-009737	Aspergillus niger	45.68	0.00e+00	816.00
IUUC-Aor-010007	Aspergillus oryzae	45.98	0.00e+00	811.00
IUUC-Ate-010466	Aspergillus terreus	45.85	0.00e+00	847.00
IUUC-Ame-010933	Astyanax mexicanus	45.36	0.00e+00	828.00
IUUC-Bgr-012281	Blumeria graminis	45.15	0.00e+00	818.00
IUUC-Bci-013721	Botrytis cinerea	45.76	0.00e+00	798.00
IUUC-Cel-018260	Caenorhabditis elegans	39.56	0.00e+00	657.00
IUUC-Cja-019152	Callithrix jacchus	45.30	0.00e+00	876.00
IUUC-Cfa-020622	Canis familiaris	43.84	0.00e+00	828.00
IUUC-Cpo-022526	Cavia porcellus	45.35	0.00e+00	864.00
IUUC-Csa-023780	Chlorocebus sabaeus	45.39	0.00e+00	880.00
IUUC-Cin-025790	Ciona intestinalis	44.32	0.00e+00	862.00
IUUC-Csv-026084	Ciona savignyi	43.47	0.00e+00	838.00
IUUC-Cne-026960	Cryptococcus neoformans	45.13	0.00e+00	857.00
IUUC-Cme-027290	Cyanidioschyzon merolae	38.78	0.00e+00	675.00
IUUC-Dre-028149	Danio rerio	45.98	0.00e+00	847.00
IUUC-Dno-028884	Dasypus novemcinctus	45.20	0.00e+00	880.00
IUUC-Dor-030229	Dipodomys ordii	43.45	0.00e+00	828.00
IUUC-Dse-031524	Dothistroma septosporum	43.76	0.00e+00	811.00
IUUC-Dme-032045	Drosophila melanogaster	44.79	0.00e+00	833.00
IUUC-Ete-033124	Echinops telfairi	39.22	4.00e-125	441.00
IUUC-Eca-033330	Equus caballus	44.90	0.00e+00	871.00
IUUC-Fca-036255	Felis catus	45.00	0.00e+00	866.00
IUUC-Fox-038007	Fusarium oxysporum	47.42	1.00e-135	476.00
IUUC-Fso-038339	Fusarium solani	46.81	0.00e+00	836.00
IUUC-Ggr-039823	Gaeumannomyces graminis	45.04	0.00e+00	855.00
IUUC-Gac-041773	Gasterosteus aculeatus	44.70	0.00e+00	838.00
IUUC-Ggo-045336	Gorilla gorilla	45.20	0.00e+00	862.00
IUUC-Hsa-045982	Homo sapiens	45.20	0.00e+00	860.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	45.10	0.00e+00	874.00
IUUC-Kpa-049112	Komagataella pastoris	47.39	0.00e+00	851.00
IUUC-Lch-050371	Latimeria chalumnae	46.67	0.00e+00	877.00
IUUC-Lpe-051299	Leersia perrieri	77.24	0.00e+00	1620.00
IUUC-Loc-052936	Lepisosteus oculatus	46.07	0.00e+00	866.00
IUUC-Lma-053315	Leptosphaeria maculans	46.31	0.00e+00	876.00
IUUC-Mcc-055843	Macaca mulatta	45.39	0.00e+00	882.00
IUUC-Meu-056258	Macropus eugenii	44.77	0.00e+00	861.00
IUUC-Mor-057269	Magnaporthe oryzae	44.90	0.00e+00	837.00
IUUC-Mpo-057435	Magnaporthe poae	45.18	0.00e+00	829.00
IUUC-Mla-059176	Melampsora laricipopulina	48.13	0.00e+00	877.00
IUUC-Mvi-060437	Microbotryum violaceum	43.74	0.00e+00	802.00
IUUC-Mmr-061405	Microcebus murinus	44.03	0.00e+00	835.00
IUUC-Mdo-062032	Monodelphis domestica	44.38	0.00e+00	852.00
IUUC-Mmu-063721	Mus musculus	45.24	0.00e+00	880.00
IUUC-Mpu-066409	Mustela putorius furo	45.29	0.00e+00	881.00
IUUC-Mlu-067217	Myotis lucifugus	45.10	0.00e+00	867.00
IUUC-Nfi-068407	Neosartorya fischeri	46.19	0.00e+00	822.00
IUUC-Ncr-068698	Neurospora crassa	46.50	0.00e+00	837.00
IUUC-Nle-070072	Nomascus leucogenys	42.66	0.00e+00	785.00
IUUC-Opr-070715	Ochotona princeps	35.69	1.00e-150	526.00
IUUC-Ont-071671	Oreochromis niloticus	45.67	0.00e+00	860.00
IUUC-Ocu-074544	Oryctolagus cuniculus	45.29	0.00e+00	879.00
IUUC-Ogu-078305	Oryza glumaepatula	77.30	0.00e+00	1613.00
IUUC-Olo-081089	Oryza longistaminata	77.60	0.00e+00	1617.00
IUUC-Oru-084469	Oryza rufipogon	77.60	0.00e+00	1617.00
IUUC-Ola-087002	Oryzias latipes	45.97	0.00e+00	861.00
IUUC-Oga-088594	Otolemur garnettii	45.21	0.00e+00	860.00
IUUC-Pan-092114	Papio anubis	45.39	0.00e+00	882.00
IUUC-Pno-095154	Phaeosphaeria nodorum	45.37	0.00e+00	847.00
IUUC-Pfo-097184	Poecilia formosa	45.36	0.00e+00	853.00
IUUC-Pab-097861	Pongo abelii	45.00	0.00e+00	845.00
IUUC-Pca-100347	Procavia capensis	42.92	0.00e+00	703.00
IUUC-Pgr-103336	Puccinia graminis	45.64	0.00e+00	822.00
IUUC-Ptt-103939	Puccinia triticina	46.42	0.00e+00	825.00
IUUC-Pte-104200	Pyrenophora teres	46.47	0.00e+00	883.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	47.36	0.00e+00	879.00
IUUC-Rno-105462	Rattus norvegicus	44.61	0.00e+00	855.00
IUUC-Sce-106245	Saccharomyces cerevisiae	46.11	0.00e+00	872.00
IUUC-Sha-107142	Sarcophilus harrisii	44.87	0.00e+00	872.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	44.71	0.00e+00	837.00
IUUC-Spo-108034	Schizosaccharomyces pombe	44.73	0.00e+00	828.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	45.66	0.00e+00	799.00
IUUC-Sar-113737	Sorex araneus	45.10	0.00e+00	866.00
IUUC-Sre-115148	Sporisorium reilianum	46.21	0.00e+00	827.00
IUUC-Ssc-115777	Sus scrofa	45.17	0.00e+00	873.00
IUUC-Tru-118742	Takifugu rubripes	45.77	0.00e+00	818.00
IUUC-Tni-120401	Tetraodon nigroviridis	46.10	0.00e+00	826.00
IUUC-Tvi-122259	Trichoderma virens	46.25	0.00e+00	819.00
IUUC-Tme-127055	Tuber melanosporum	44.63	0.00e+00	799.00
IUUC-Ttr-128331	Tursiops truncatus	45.39	0.00e+00	867.00
IUUC-Uma-129387	Ustilago maydis	45.71	0.00e+00	822.00
IUUC-Vda-129977	Verticillium dahliae	47.72	0.00e+00	816.00
IUUC-Vpa-130716	Vicugna pacos	38.25	0.00e+00	650.00
IUUC-Xtr-132026	Xenopus tropicalis	39.92	0.00e+00	661.00
IUUC-Xma-133805	Xiphophorus maculatus	45.56	0.00e+00	840.00
IUUC-Yli-134547	Yarrowia lipolytica	45.57	0.00e+00	854.00
IUUC-Zma-135052	Zea mays	79.65	0.00e+00	1673.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence