iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008360

Ensembl Protein ID

CADACLAP00007273

UniProt Accession

A1CUD6; LIS11_ASPCL

Genbank Protein ID

EAW06923.1

Protein Name

Nuclear distribution protein nudF 1; Lissencephaly-1 homolog 1

Genbank Nucleotide ID

DS027060

Gene Name

ACLA_086220; nudF-1; lis1-1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00007464	CADACLAT00007464	CADACLAP00007273

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-49	161.3	354	388
UBD/Beta-Prp	3.20e-67	225.7	112	465

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH ++v++laf ++ ++l+s sdD+ti++WDl++ 
   Q: 354  GHDNWVRALAFhPGgKYLLSVSDDKTIRCWDLTQE 388
           8***********999****************9975 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkgheds 96
           ++h s++tcv+f+p  s la+gs+d tik+wd++ g l r+++gh+++v +v++   +   +l+++s+D tik+wd+s ++k ++tl gh++s
   Q: 112  ESHRSPVTCVAFHPVFSSLASGSDDTTIKIWDWELGELERTVKGHTKAVLDVDYGGPRGgtLLASCSSDLTIKLWDPSdDYKNIRTLPGHDHS 204
           56888*************************************************7544446**************88769************* PP
   S: 97   vlslsfsp........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           v s++f p        sg+ lvs+s+d+t+r+wd+ tg+c++ tlsgh ++v+ v+ + dg+ l+++++Dr+ rlWdl+ ++   t+ g h++
   Q: 205  VSSVRFIPsgaagspmSGNLLVSASRDKTLRIWDVTTGYCVK-TLSGHVDWVRAVAPSIDGRFLFAAGDDRIPRLWDLSAAETRSTFLG-HEH 295
           ******999999999999************************.******************9999999********************9.*** PP
   S: 182  svyslsfdsng.....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
            ++++++ +                       +++++gs+d+t++lwd  +g+ ++tl gh+++v+ ++f+p +++l+s+s+D++ir+Wdl++
   Q: 296  VIECVAIAPAAsyphlavlsglkkppsasssaEFFATGSRDKTIRLWDS-RGNLIKTLVGHDNWVRALAFHPGGKYLLSVSDDKTIRCWDLTQ 387
           ******55555555555666666666666667****************8.7889************************************976 PP
   S: 254  g.dllktlqlhn........................ssvisvavlsfgdnvl............................vlgsedskvniw 292
             ++++t++ ++                                                                    ++gs d+kv+++
   Q: 388  EcKCVRTIADTHehfvtclrwapplikdsgangdagA--------------NgtpaatttsngarqdpnaankisircviATGSVDQKVRVF 465
           549*******995344443333333333333333331..............04444444444444444444444455544777777777777 PP

Organism

Aspergillus clavatus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSQLLTTRQA EELHKSIIAY LASVNLSESA TTLRAELGDA VTIDDATIKK YEGLLEKKWT 60
SVVRLQKKIM DLESRCAALQ SELDSATPTS LLRKNQDPTA WLPRAPPRHT LESHRSPVTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCAGT TACTCACGAC GCGGCAGGCA GAGGAGCTGT ATGTCCCTGG TCCTGCACAA 60
CTGGGAAGGC TGTGAGAGAA CGAGTTTGAA GAAGCTGACC GCGCTCGACA CTCTGCAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

act:ACLA_086220

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	46.95	5.00e-104	369.00
IUUC-Apl-004024	Anas platyrhynchos	47.03	2.00e-107	380.00
IUUC-Aca-004564	Anolis carolinensis	46.53	5.00e-105	372.00
IUUC-Ago-007862	Ashbya gossypii	29.95	1.00e-40	158.00
IUUC-Afl-008502	Aspergillus flavus	62.78	8.00e-162	561.00
IUUC-Afu-008848	Aspergillus fumigatus	92.29	0.00e+00	892.00
IUUC-Ani-009173	Aspergillus nidulans	59.74	1.00e-161	561.00
IUUC-Ang-009873	Aspergillus niger	57.42	6.00e-156	541.00
IUUC-Ate-010523	Aspergillus terreus	59.14	7.00e-164	568.00
IUUC-Ame-010969	Astyanax mexicanus	46.53	7.00e-107	378.00
IUUC-Bgr-011972	Blumeria graminis	68.31	0.00e+00	663.00
IUUC-Bta-013106	Bos taurus	47.03	2.00e-107	380.00
IUUC-Bci-013615	Botrytis cinerea	73.66	0.00e+00	692.00
IUUC-Cel-018459	Caenorhabditis elegans	42.68	2.00e-93	334.00
IUUC-Cja-018755	Callithrix jacchus	46.55	7.00e-105	372.00
IUUC-Cfa-020749	Canis familiaris	47.03	2.00e-107	380.00
IUUC-Cpo-022371	Cavia porcellus	47.03	2.00e-107	380.00
IUUC-Csa-023524	Chlorocebus sabaeus	47.63	2.00e-90	324.00
IUUC-Cho-024764	Choloepus hoffmanni	44.69	2.00e-89	320.00
IUUC-Cin-025753	Ciona intestinalis	44.39	7.00e-98	348.00
IUUC-Csv-025817	Ciona savignyi	44.63	3.00e-101	360.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	72.82	0.00e+00	673.00
IUUC-Cne-027087	Cryptococcus neoformans	52.26	2.00e-113	400.00
IUUC-Dre-028314	Danio rerio	46.53	2.00e-107	380.00
IUUC-Dno-029050	Dasypus novemcinctus	47.03	2.00e-107	380.00
IUUC-Dor-030222	Dipodomys ordii	43.42	1.00e-97	348.00
IUUC-Dse-031164	Dothistroma septosporum	68.15	0.00e+00	643.00
IUUC-Dme-031745	Drosophila melanogaster	45.45	1.00e-96	345.00
IUUC-Ete-032508	Echinops telfairi	47.57	8.00e-71	258.00
IUUC-Eca-034288	Equus caballus	46.45	4.00e-103	365.00
IUUC-Eeu-034984	Erinaceus europaeus	43.18	2.00e-96	344.00
IUUC-Fca-036498	Felis catus	47.03	2.00e-107	380.00
IUUC-Fal-036920	Ficedula albicollis	47.03	2.00e-107	380.00
IUUC-Fox-037996	Fusarium oxysporum	69.05	0.00e+00	671.00
IUUC-Fso-038160	Fusarium solani	66.45	0.00e+00	640.00
IUUC-Gmo-038983	Gadus morhua	46.53	3.00e-107	379.00
IUUC-Ggr-040051	Gaeumannomyces graminis	66.81	0.00e+00	636.00
IUUC-Gga-040623	Gallus gallus	47.03	2.00e-107	380.00
IUUC-Gac-041613	Gasterosteus aculeatus	47.04	3.00e-107	380.00
IUUC-Ggo-045410	Gorilla gorilla	43.21	5.00e-88	316.00
IUUC-Hsa-046358	Homo sapiens	47.03	2.00e-107	380.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	47.03	2.00e-107	380.00
IUUC-Kpa-049351	Komagataella pastoris	30.11	5.00e-48	183.00
IUUC-Lch-049936	Latimeria chalumnae	46.53	4.00e-107	379.00
IUUC-Loc-052476	Lepisosteus oculatus	46.70	2.00e-103	367.00
IUUC-Lma-053170	Leptosphaeria maculans	74.41	0.00e+00	684.00
IUUC-Laf-053713	Loxodonta africana	46.17	2.00e-105	373.00
IUUC-Mcc-054628	Macaca mulatta	47.03	4.00e-107	379.00
IUUC-Meu-055927	Macropus eugenii	38.95	2.00e-51	193.00
IUUC-Mor-056962	Magnaporthe oryzae	69.57	0.00e+00	672.00
IUUC-Mpo-057583	Magnaporthe poae	67.02	3.00e-178	615.00
IUUC-Mla-058819	Melampsora laricipopulina	45.24	3.00e-113	399.00
IUUC-Mga-059945	Meleagris gallopavo	46.78	5.00e-107	379.00
IUUC-Mvi-060403	Microbotryum violaceum	50.21	2.00e-127	447.00
IUUC-Mmr-061289	Microcebus murinus	46.52	2.00e-104	370.00
IUUC-Mdo-061912	Monodelphis domestica	46.78	3.00e-106	376.00
IUUC-Mmu-063253	Mus musculus	47.03	2.00e-107	380.00
IUUC-Mpu-066638	Mustela putorius furo	47.03	2.00e-107	380.00
IUUC-Mlu-067267	Myotis lucifugus	46.15	1.00e-104	371.00
IUUC-Nfi-068571	Neosartorya fischeri	86.30	0.00e+00	802.00
IUUC-Ncr-068862	Neurospora crassa	69.05	0.00e+00	634.00
IUUC-Nle-069087	Nomascus leucogenys	45.30	1.00e-87	314.00
IUUC-Opr-070579	Ochotona princeps	47.03	2.00e-107	380.00
IUUC-Ont-072432	Oreochromis niloticus	47.04	1.00e-106	378.00
IUUC-Oan-073072	Ornithorhynchus anatinus	47.03	2.00e-107	380.00
IUUC-Ocu-074180	Oryctolagus cuniculus	47.03	2.00e-107	380.00
IUUC-Ola-086815	Oryzias latipes	46.78	2.00e-107	380.00
IUUC-Oga-088219	Otolemur garnettii	46.17	3.00e-105	373.00
IUUC-Oar-090394	Ovis aries	47.03	2.00e-107	380.00
IUUC-Ptr-091517	Pan troglodytes	47.03	2.00e-107	380.00
IUUC-Pan-092421	Papio anubis	47.03	4.00e-107	379.00
IUUC-Psi-093370	Pelodiscus sinensis	47.03	4.00e-107	379.00
IUUC-Pma-094319	Petromyzon marinus	46.18	1.00e-88	318.00
IUUC-Pno-094815	Phaeosphaeria nodorum	73.23	0.00e+00	695.00
IUUC-Pfo-097089	Poecilia formosa	46.78	1.00e-107	381.00
IUUC-Pab-098421	Pongo abelii	47.03	2.00e-107	380.00
IUUC-Pca-100120	Procavia capensis	37.39	6.00e-61	226.00
IUUC-Pva-102960	Pteropus vampyrus	46.78	7.00e-106	375.00
IUUC-Pgr-103538	Puccinia graminis	49.05	2.00e-121	427.00
IUUC-Ptt-103990	Puccinia triticina	43.46	1.00e-42	166.00
IUUC-Pte-104261	Pyrenophora teres	73.23	0.00e+00	687.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	73.45	0.00e+00	688.00
IUUC-Rno-105123	Rattus norvegicus	47.03	2.00e-107	380.00
IUUC-Sce-106208	Saccharomyces cerevisiae	27.38	2.00e-36	144.00
IUUC-Sha-107010	Sarcophilus harrisii	46.78	2.00e-106	377.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	37.29	4.00e-72	263.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	74.77	0.00e+00	666.00
IUUC-Sar-113309	Sorex araneus	46.19	2.00e-101	360.00
IUUC-Sre-115003	Sporisorium reilianum	50.64	2.00e-127	446.00
IUUC-Ssc-116148	Sus scrofa	47.03	2.00e-107	380.00
IUUC-Tgu-117299	Taeniopygia guttata	47.03	2.00e-107	380.00
IUUC-Tru-117721	Takifugu rubripes	46.80	3.00e-107	380.00
IUUC-Tsy-119493	Tarsius syrichta	46.78	1.00e-105	374.00
IUUC-Tni-120355	Tetraodon nigroviridis	46.55	8.00e-106	375.00
IUUC-Tre-121977	Trichoderma reesei	64.54	3.00e-173	599.00
IUUC-Tvi-122661	Trichoderma virens	65.03	2.00e-170	590.00
IUUC-Tme-127031	Tuber melanosporum	66.52	4.00e-180	622.00
IUUC-Tbe-127492	Tupaia belangeri	39.70	1.00e-48	184.00
IUUC-Ttr-128929	Tursiops truncatus	47.03	4.00e-107	379.00
IUUC-Uma-129347	Ustilago maydis	50.43	2.00e-125	440.00
IUUC-Vda-129837	Verticillium dahliae	73.56	0.00e+00	662.00
IUUC-Vpa-130532	Vicugna pacos	40.20	2.00e-86	310.00
IUUC-Xtr-131985	Xenopus tropicalis	47.03	9.00e-108	381.00
IUUC-Xma-133314	Xiphophorus maculatus	46.75	1.00e-107	380.00
IUUC-Yli-134403	Yarrowia lipolytica	41.51	2.00e-99	353.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence