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Tag Content
iUUCD ID IUUC-Oar-090220
Ensembl Protein ID ENSOARP00000004434.1
UniProt Accession W5P1Y5; W5P1Y5_SHEEP
Genbank Protein ID ENSOARP00000004434
Protein Name Uncharacterized protein
Genbank Nucleotide ID AMGL01037161
Gene Name FBXW7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOARG00000004146.1 ENSOART00000004512.1 ENSOARP00000004434.1
ENSOARG00000004146.1 ENSOART00000004513.1 ENSOARP00000004435.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.10e-61 199.4 625 658
UBD/Beta-Prp 5.00e-96 321.6 372 658
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 625  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 658
           9*********449******************976 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 372  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 456
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           gh+++v+++++++  ++ ++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g 
   Q: 457  GHTSTVRCMHLHEksYTRRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG- 541
           *************9888************************.****************..***************************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           ht++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ 
   Q: 542  HTNRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 626
           ***********9..9**************************************..********************************** PP
   S: 268  isvavlsfgdnvlvlgsedskvniwklkknep 299
           ++v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 627  SAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 658
           ***************************98776 PP
   
Organism Ovis aries
Protein Sequence
(Fasta)
MNQELLSVGS KRRRTGGSLR GNPSSSQADE EQMNRVVEEE QQPRHQEEEH AARNGEVVGA 60
EPRPGGQSES QQGQLEENNN RFISVEEDSS GNQEEQEEDE EHAGEQDEED EEDEEMDQES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oar-090220|E3,WD_repeat;UBD,Beta-Prp|Ovis aries
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGCAGCC TCCGCCCAGA AGAAACTTTA TAAGTCAGAA ATCCGGAGCC TCCCAAACGG 60
GACTGTCGGG GAGAAGTGGC CCGGGACGCG CAGAAGACCC AGCCTGAAGA GACCCGGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oar-090220|E3,WD_repeat;UBD,Beta-Prp|Ovis aries
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 96.07 0.00e+00 1217.00
IUUC-Apl-003489 Anas platyrhynchos 89.31 0.00e+00 1186.00
IUUC-Aca-005318 Anolis carolinensis 98.53 0.00e+00 1097.00
IUUC-Ago-007794 Ashbya gossypii 31.02 9.00e-62 231.00
IUUC-Acl-008123 Aspergillus clavatus 32.21 1.00e-74 274.00
IUUC-Afl-008730 Aspergillus flavus 31.19 1.00e-73 271.00
IUUC-Afu-009014 Aspergillus fumigatus 32.34 3.00e-75 276.00
IUUC-Ani-009332 Aspergillus nidulans 33.27 4.00e-80 292.00
IUUC-Ang-009790 Aspergillus niger 31.33 4.00e-75 275.00
IUUC-Aor-010215 Aspergillus oryzae 30.53 2.00e-74 273.00
IUUC-Ate-010535 Aspergillus terreus 31.90 5.00e-76 278.00
IUUC-Ame-010898 Astyanax mexicanus 94.31 0.00e+00 1043.00
IUUC-Bgr-012075 Blumeria graminis 33.20 1.00e-79 290.00
IUUC-Bta-012391 Bos taurus 99.27 0.00e+00 1100.00
IUUC-Bci-013725 Botrytis cinerea 33.01 3.00e-78 286.00
IUUC-Cel-018495 Caenorhabditis elegans 36.28 3.00e-93 335.00
IUUC-Cja-018902 Callithrix jacchus 96.34 0.00e+00 1211.00
IUUC-Cfa-020237 Canis familiaris 95.67 0.00e+00 1218.00
IUUC-Cpo-022234 Cavia porcellus 99.27 0.00e+00 1102.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.05 3.00e-47 182.00
IUUC-Csa-023532 Chlorocebus sabaeus 96.34 0.00e+00 1188.00
IUUC-Cho-025026 Choloepus hoffmanni 82.70 0.00e+00 763.00
IUUC-Cin-025516 Ciona intestinalis 69.49 9.00e-140 489.00
IUUC-Csv-026312 Ciona savignyi 74.84 0.00e+00 751.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 34.61 7.00e-85 308.00
IUUC-Cne-027018 Cryptococcus neoformans 33.46 8.00e-74 272.00
IUUC-Cme-027168 Cyanidioschyzon merolae 30.88 2.00e-31 130.00
IUUC-Dre-028303 Danio rerio 93.39 0.00e+00 1045.00
IUUC-Dno-029576 Dasypus novemcinctus 94.09 0.00e+00 1193.00
IUUC-Dor-030196 Dipodomys ordii 91.15 0.00e+00 1202.00
IUUC-Dse-031558 Dothistroma septosporum 38.94 3.00e-70 259.00
IUUC-Dme-031702 Drosophila melanogaster 76.00 0.00e+00 799.00
IUUC-Ete-032791 Echinops telfairi 90.26 0.00e+00 1001.00
IUUC-Eca-033424 Equus caballus 99.27 0.00e+00 1101.00
IUUC-Eeu-034996 Erinaceus europaeus 92.58 0.00e+00 1177.00
IUUC-Fca-036422 Felis catus 95.24 0.00e+00 1231.00
IUUC-Fal-037267 Ficedula albicollis 98.53 0.00e+00 1092.00
IUUC-Fox-037800 Fusarium oxysporum 33.86 2.00e-84 306.00
IUUC-Fso-038258 Fusarium solani 34.00 3.00e-83 303.00
IUUC-Gmo-039119 Gadus morhua 83.49 0.00e+00 900.00
IUUC-Ggr-039781 Gaeumannomyces graminis 34.65 4.00e-85 309.00
IUUC-Gga-040667 Gallus gallus 91.96 0.00e+00 1180.00
IUUC-Gac-042423 Gasterosteus aculeatus 74.54 0.00e+00 798.00
IUUC-Ggo-044422 Gorilla gorilla 96.34 0.00e+00 1193.00
IUUC-Hsa-045898 Homo sapiens 96.20 0.00e+00 1192.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 98.94 0.00e+00 968.00
IUUC-Kpa-049097 Komagataella pastoris 32.06 2.00e-76 280.00
IUUC-Lch-050414 Latimeria chalumnae 93.90 0.00e+00 1088.00
IUUC-Loc-052348 Lepisosteus oculatus 96.51 0.00e+00 1070.00
IUUC-Lma-053185 Leptosphaeria maculans 32.41 4.00e-72 266.00
IUUC-Laf-054054 Loxodonta africana 95.10 0.00e+00 1229.00
IUUC-Mcc-055056 Macaca mulatta 96.34 0.00e+00 1188.00
IUUC-Meu-056778 Macropus eugenii 92.16 0.00e+00 729.00
IUUC-Mor-057076 Magnaporthe oryzae 34.12 8.00e-85 308.00
IUUC-Mpo-057423 Magnaporthe poae 40.00 1.00e-71 264.00
IUUC-Mla-059081 Melampsora laricipopulina 32.45 6.00e-74 271.00
IUUC-Mga-059255 Meleagris gallopavo 91.56 0.00e+00 1169.00
IUUC-Mvi-060490 Microbotryum violaceum 38.75 2.00e-67 251.00
IUUC-Mmr-061292 Microcebus murinus 96.20 0.00e+00 1215.00
IUUC-Mdo-062304 Monodelphis domestica 91.71 0.00e+00 1205.00
IUUC-Mmu-063610 Mus musculus 92.16 0.00e+00 1269.00
IUUC-Mpu-065931 Mustela putorius furo 95.79 0.00e+00 1217.00
IUUC-Mlu-066976 Myotis lucifugus 95.37 0.00e+00 1249.00
IUUC-Nfi-068428 Neosartorya fischeri 31.74 4.00e-75 275.00
IUUC-Ncr-068688 Neurospora crassa 35.74 3.00e-87 316.00
IUUC-Nle-070174 Nomascus leucogenys 96.06 0.00e+00 1191.00
IUUC-Opr-070851 Ochotona princeps 85.68 0.00e+00 649.00
IUUC-Ont-071997 Oreochromis niloticus 93.76 0.00e+00 1068.00
IUUC-Oan-072936 Ornithorhynchus anatinus 92.96 0.00e+00 1235.00
IUUC-Ocu-074742 Oryctolagus cuniculus 98.93 0.00e+00 1131.00
IUUC-Ola-087098 Oryzias latipes 93.39 0.00e+00 1055.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.08 1.00e-37 149.00
IUUC-Oga-088884 Otolemur garnettii 98.96 0.00e+00 779.00
IUUC-Ptr-090492 Pan troglodytes 96.20 0.00e+00 1192.00
IUUC-Pan-091770 Papio anubis 96.62 0.00e+00 1188.00
IUUC-Psi-093207 Pelodiscus sinensis 99.27 0.00e+00 1102.00
IUUC-Pma-094749 Petromyzon marinus 83.06 0.00e+00 941.00
IUUC-Pno-095026 Phaeosphaeria nodorum 38.56 1.00e-70 261.00
IUUC-Pfo-096493 Poecilia formosa 94.86 0.00e+00 1054.00
IUUC-Pab-098141 Pongo abelii 99.27 0.00e+00 1102.00
IUUC-Pca-100571 Procavia capensis 95.41 0.00e+00 837.00
IUUC-Pva-102988 Pteropus vampyrus 95.79 0.00e+00 1223.00
IUUC-Pgr-103612 Puccinia graminis 35.66 3.00e-62 233.00
IUUC-Ptt-103698 Puccinia triticina 35.55 7.00e-42 166.00
IUUC-Pte-104275 Pyrenophora teres 32.37 2.00e-73 270.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 38.76 7.00e-70 258.00
IUUC-Rno-105706 Rattus norvegicus 97.04 0.00e+00 1140.00
IUUC-Sce-106314 Saccharomyces cerevisiae 29.19 6.00e-62 232.00
IUUC-Sha-107653 Sarcophilus harrisii 94.24 0.00e+00 1231.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 33.46 2.00e-79 290.00
IUUC-Spo-108115 Schizosaccharomyces pombe 31.88 3.00e-61 229.00
IUUC-Sar-113600 Sorex araneus 91.14 0.00e+00 1107.00
IUUC-Sre-114901 Sporisorium reilianum 43.90 3.00e-67 250.00
IUUC-Ssc-115787 Sus scrofa 95.63 0.00e+00 1197.00
IUUC-Tgu-117510 Taeniopygia guttata 91.56 0.00e+00 1175.00
IUUC-Tru-117819 Takifugu rubripes 93.47 0.00e+00 1079.00
IUUC-Tsy-118828 Tarsius syrichta 95.79 0.00e+00 1227.00
IUUC-Tni-120468 Tetraodon nigroviridis 94.13 0.00e+00 1068.00
IUUC-Tre-122193 Trichoderma reesei 36.02 3.00e-85 309.00
IUUC-Tvi-122615 Trichoderma virens 34.82 1.00e-83 303.00
IUUC-Tme-127021 Tuber melanosporum 34.34 2.00e-83 303.00
IUUC-Tbe-127925 Tupaia belangeri 99.26 0.00e+00 1100.00
IUUC-Ttr-128899 Tursiops truncatus 96.48 0.00e+00 1218.00
IUUC-Uma-129449 Ustilago maydis 46.50 2.00e-66 248.00
IUUC-Vda-129802 Verticillium dahliae 35.98 9.00e-88 317.00
IUUC-Vpa-130082 Vicugna pacos 95.82 0.00e+00 1035.00
IUUC-Xtr-132213 Xenopus tropicalis 85.01 0.00e+00 1160.00
IUUC-Xma-133646 Xiphophorus maculatus 94.69 0.00e+00 1050.00
IUUC-Yli-134429 Yarrowia lipolytica 34.07 2.00e-86 313.00
Created Date 25-Jun-2017

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