iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030397.10	ENSMUST00000085715.6	ENSMUSP00000082862.5
ENSMUSG00000030397.10	ENSMUST00000209058.1	ENSMUSP00000147002.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	97.61	0.00e+00	1355.00	IUUC-Hsa-045897

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity).

Protein Sequence
(Fasta)

MSSRTALAPG NDRNSDTHGT LGSGRSSDKG PSWSSRSLGA RCRNSIASCP EEQPHVGNYR 60
LLRTIGKGNF AKVKLARHIL TGREVAIKII DKTQLNPSSL QKLFREVRIM KGLNHPNIVK 120

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Nucleotide Sequence
(Fasta)

GGTCGCCTCC CTCCGCCGCC GCCCCGGGCC GGCTCCGCGC CCCCTCCCCG GCCCCCGCCC 60
GTGCACCCTC CCGCCTGCCC GCCGCCCAGA TGGCGCCCCG GGTTCCCCTT GCACGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0418--Kinase
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA

PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0000930--C:gamma-tubulin complex
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0005815--C:microtubule organizing center
GO:0043005--C:neuron projection
GO:0005524--F:ATP binding
GO:0043015--F:gamma-tubulin binding
GO:0008017--F:microtubule binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0051301--P:cell division
GO:0030030--P:cell projection organization
GO:0030010--P:establishment of cell polarity
GO:0001578--P:microtubule bundle formation
GO:0000226--P:microtubule cytoskeleton organization
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0008284--P:positive regulation of cell proliferation

KEGG

mmu:232944

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013546	Bos taurus	96.74	0.00e+00	1263.00
IUUC-Cja-019522	Callithrix jacchus	98.01	0.00e+00	1336.00
IUUC-Cfa-020231	Canis familiaris	95.28	0.00e+00	1273.00
IUUC-Cpo-022532	Cavia porcellus	96.28	0.00e+00	1279.00
IUUC-Csa-023700	Chlorocebus sabaeus	95.49	0.00e+00	1268.00
IUUC-Dor-030478	Dipodomys ordii	94.83	0.00e+00	1212.00
IUUC-Eca-033684	Equus caballus	95.14	0.00e+00	1059.00
IUUC-Fca-035898	Felis catus	96.73	0.00e+00	1306.00
IUUC-Gmo-039460	Gadus morhua	72.58	0.00e+00	949.00
IUUC-Gac-042324	Gasterosteus aculeatus	68.73	0.00e+00	983.00
IUUC-Ggo-044770	Gorilla gorilla	93.90	0.00e+00	1207.00
IUUC-Hsa-045897	Homo sapiens	97.61	0.00e+00	1322.00
IUUC-Itr-049080	Ictidomys tridecemlineatus	97.60	0.00e+00	1369.00
IUUC-Lch-049752	Latimeria chalumnae	67.97	0.00e+00	947.00
IUUC-Laf-053534	Loxodonta africana	93.61	0.00e+00	1272.00
IUUC-Mcc-054804	Macaca mulatta	97.74	0.00e+00	1303.00
IUUC-Meu-056140	Macropus eugenii	93.88	0.00e+00	1324.00
IUUC-Mmr-060587	Microcebus murinus	97.61	0.00e+00	1340.00
IUUC-Mlu-067933	Myotis lucifugus	83.86	0.00e+00	1030.00
IUUC-Nle-069719	Nomascus leucogenys	92.10	0.00e+00	1039.00
IUUC-Opr-070607	Ochotona princeps	89.49	0.00e+00	1215.00
IUUC-Ont-071444	Oreochromis niloticus	70.80	0.00e+00	1011.00
IUUC-Ola-086790	Oryzias latipes	63.92	0.00e+00	921.00
IUUC-Oga-088194	Otolemur garnettii	97.61	0.00e+00	1302.00
IUUC-Ptr-091413	Pan troglodytes	97.74	0.00e+00	1304.00
IUUC-Pab-098074	Pongo abelii	95.88	0.00e+00	1261.00
IUUC-Pva-103242	Pteropus vampyrus	97.87	0.00e+00	1280.00
IUUC-Rno-105368	Rattus norvegicus	99.20	0.00e+00	1348.00
IUUC-Tru-117575	Takifugu rubripes	67.31	0.00e+00	918.00
IUUC-Ttr-129093	Tursiops truncatus	95.10	0.00e+00	1225.00
IUUC-Xtr-132367	Xenopus tropicalis	72.62	0.00e+00	846.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence