iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000039985.5	ENSRNOT00000083861.2	ENSRNOP00000074590.1
ENSRNOG00000039985.5	ENSRNOT00000061455.5	ENSRNOP00000058174.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.70e-51	172.1	8	152

Active Site

Position(s)	Description	Evidence
98	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYegg..........vFkleiefpedYPfkPPkvkfltkifhPnvyenG 79
           Rl++++k+l++dpp+g+s  p+++ +++ w+++i+Gpe+tp+e+g          +Fkl+ief+e+YP kPP+v+f++k+fhPnvy++G
   Q: 8    RLMRDFKRLQEDPPAGVSGAPSEN-NIMVWNAVIFGPEGTPFEDGthvettgqlgTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADG 95
           9**********************9.9****************98633333333337********************************* PP
   S: 80   kvClsilkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Cl+il+  ++Wsp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 96   SICLDILQ--NRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 152
           *******9..**********************************************996 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTHVETTGQL 60
GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGTTCTC CTCAGGTTGG TTCGGCCCCC GTCTACTCAG GGGTGGTGCT TAGCCGGCGC 60
CAGACCGACC CTCGGCTTCG GAGAGGTAGT GCTGTTCCTC TCGGTGCTCC CTCGGCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006281--P:DNA repair
GO:0033522--P:histone H2A ubiquitination
GO:0016574--P:histone ubiquitination
GO:0001701--P:in utero embryonic development
GO:0060135--P:maternal process involved in female pregnancy
GO:0008284--P:positive regulation of cell proliferation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0009411--P:response to UV

KEGG

rno:298317

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011594	Astyanax mexicanus	93.83	2.00e-86	310.00
IUUC-Cja-018783	Callithrix jacchus	93.83	2.00e-86	310.00
IUUC-Cpo-021323	Cavia porcellus	93.21	3.00e-86	310.00
IUUC-Csa-023588	Chlorocebus sabaeus	93.83	2.00e-86	310.00
IUUC-Dre-028358	Danio rerio	93.83	2.00e-86	310.00
IUUC-Eca-033562	Equus caballus	92.07	8.00e-85	305.00
IUUC-Eeu-035191	Erinaceus europaeus	75.31	2.00e-64	237.00
IUUC-Fca-036581	Felis catus	93.83	2.00e-86	310.00
IUUC-Fal-037474	Ficedula albicollis	92.25	2.00e-66	243.00
IUUC-Gmo-038517	Gadus morhua	93.83	2.00e-86	310.00
IUUC-Gga-040588	Gallus gallus	93.83	2.00e-86	310.00
IUUC-Gac-041504	Gasterosteus aculeatus	93.21	5.00e-86	309.00
IUUC-Ggo-044896	Gorilla gorilla	93.83	2.00e-86	310.00
IUUC-Hsa-046383	Homo sapiens	93.83	2.00e-86	310.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	93.83	2.00e-86	310.00
IUUC-Lch-049964	Latimeria chalumnae	93.83	2.00e-86	310.00
IUUC-Loc-051731	Lepisosteus oculatus	93.83	2.00e-86	310.00
IUUC-Laf-053680	Loxodonta africana	93.83	2.00e-86	310.00
IUUC-Mcc-055546	Macaca mulatta	93.83	6.00e-86	310.00
IUUC-Meu-056231	Macropus eugenii	93.83	2.00e-86	310.00
IUUC-Mmr-060956	Microcebus murinus	91.98	5.00e-83	299.00
IUUC-Mdo-062292	Monodelphis domestica	93.83	2.00e-86	310.00
IUUC-Mmu-063680	Mus musculus	93.83	2.00e-86	310.00
IUUC-Nle-069121	Nomascus leucogenys	93.83	2.00e-86	310.00
IUUC-Ocu-074550	Oryctolagus cuniculus	93.83	4.00e-86	310.00
IUUC-Olo-081018	Oryza longistaminata	68.07	3.00e-64	237.00
IUUC-Ola-086407	Oryzias latipes	93.83	2.00e-86	310.00
IUUC-Oga-088659	Otolemur garnettii	93.83	2.00e-86	310.00
IUUC-Ptr-091305	Pan troglodytes	93.83	2.00e-86	310.00
IUUC-Pan-092740	Papio anubis	93.83	6.00e-86	310.00
IUUC-Psi-094094	Pelodiscus sinensis	93.83	2.00e-86	310.00
IUUC-Pfo-096656	Poecilia formosa	93.21	3.00e-86	310.00
IUUC-Pab-097972	Pongo abelii	93.83	2.00e-86	310.00
IUUC-Pca-100906	Procavia capensis	87.65	5.00e-79	285.00
IUUC-Pva-102380	Pteropus vampyrus	92.59	9.00e-85	305.00
IUUC-Ssc-116265	Sus scrofa	93.83	2.00e-86	310.00
IUUC-Tgu-117383	Taeniopygia guttata	93.83	2.00e-86	310.00
IUUC-Tru-117924	Takifugu rubripes	94.44	2.00e-83	300.00
IUUC-Tni-119743	Tetraodon nigroviridis	90.12	2.00e-82	297.00
IUUC-Tca-121551	Theobroma cacao	74.21	5.00e-70	256.00
IUUC-Ttr-129050	Tursiops truncatus	93.17	2.00e-83	300.00
IUUC-Xtr-132301	Xenopus tropicalis	93.83	2.00e-86	310.00
IUUC-Xma-133937	Xiphophorus maculatus	93.83	2.00e-86	310.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence