iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000059871.6	ENSDART00000083719.6	ENSDARP00000078154.4
ENSDARG00000059871.6	ENSDART00000173687.1	ENSDARP00000142955.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.80e-11	43.6	399	425
ULD/UDP/UBQ/UBQ_Other	1.40e-10	41.8	227	296

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
           ++WaC++CT++N+P +++CemCs  R+
   Q: 399  PGWACPTCTYINKPTRPGCEMCSADRP 425
           79**********************998 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadygl.kdgstihll 70
           v+v+++ +s   ++kv p++t++ LK+++++  g++p+ qr+++ G+ L  d+++La+yg+ +dg+t++l+
   Q: 227  VVVEDASSScCVSVKVFPHSTIGALKQQVFSDYGFHPRVQRWVI-GQSLcSDHRSLASYGVqRDGDTAFLY 296
           7899999999**********************************.66666*********662699999998 PP

Organism

Danio rerio

Functional Description
(View)

Component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.

Protein Sequence
(Fasta)

MSLSSGGWTR ASPPAQSSSS HLGHEASQSA CSTVLMSVKV SVCHSGIRPL CLPGAGDESL 60
RLQLSMDPGK AGEFRLALRD ISATAAGRSV FIAEFDLKTV QYEVKTPLCH ELSLATPPHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGAGCCG TGTGTTTCTT CCTGCTCTGA CGCTCAACTT CCCTCTATCC GAAACTAAAA 60
CAAAGATGAC AAGGCCGCGA CTTTTGCGTA AATGTCCGGA TCAGAGAGTT GTAGGACATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002867--IBR_dom
IPR011993--PH_dom-like
IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF16764--Sharpin_PH
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0016874--F:ligase activity
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0071600--P:otic vesicle morphogenesis
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination

KEGG

dre:569903

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003627	Anas platyrhynchos	67.31	3.00e-17	79.30
IUUC-Aca-004762	Anolis carolinensis	52.14	0.00e+00	655.00
IUUC-Ame-011545	Astyanax mexicanus	75.41	0.00e+00	1003.00
IUUC-Csv-026069	Ciona savignyi	54.80	4.00e-84	304.00
IUUC-Cne-026853	Cryptococcus neoformans	38.98	1.00e-03	38.10
IUUC-Eeu-034454	Erinaceus europaeus	72.90	6.00e-47	181.00
IUUC-Fal-037440	Ficedula albicollis	57.14	5.00e-21	92.00
IUUC-Gmo-038561	Gadus morhua	82.45	1.00e-147	516.00
IUUC-Gga-040198	Gallus gallus	46.54	7.00e-48	184.00
IUUC-Gac-041319	Gasterosteus aculeatus	67.16	0.00e+00	696.00
IUUC-Lch-050269	Latimeria chalumnae	53.08	0.00e+00	687.00
IUUC-Loc-052776	Lepisosteus oculatus	69.76	0.00e+00	932.00
IUUC-Meu-055912	Macropus eugenii	38.98	2.00e-30	126.00
IUUC-Mga-059615	Meleagris gallopavo	67.69	2.00e-21	93.20
IUUC-Ont-071314	Oreochromis niloticus	70.82	0.00e+00	934.00
IUUC-Ola-087012	Oryzias latipes	65.45	0.00e+00	865.00
IUUC-Pma-094407	Petromyzon marinus	45.16	5.00e-133	468.00
IUUC-Pfo-096767	Poecilia formosa	67.82	0.00e+00	1003.00
IUUC-Sha-107342	Sarcophilus harrisii	50.46	2.00e-152	532.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	24.52	1.00e-03	37.70
IUUC-Tru-118096	Takifugu rubripes	70.44	0.00e+00	751.00
IUUC-Tni-120890	Tetraodon nigroviridis	68.09	0.00e+00	668.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence