iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167470.12	ENST00000591446.6	ENSP00000467679.1
ENSG00000167470.12	ENST00000586843.2	ENSP00000466835.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	10974535

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	7.40e-10	40.2	32	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           ++ + s++g++++l v+p++tV  L+++++++l++p e+ +L+ k++ L  + +L+++g+ dgs++ l+++++ 
   Q: 32   SLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSG-KLQEFGVGDGSKLTLVPTVEA 104
           6778999******************************************999.*****************9875 PP

Organism

Homo sapiens

Functional Description
(View)

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Protein Sequence
(Fasta)

MEPQPGGARS CRRGAPGGAC ELGPAAEAAP MSLAIHSTTG TRYDLAVPPD ETVEGLRKRL 60
SQRLKVPKER LALLHKDTRL SSGKLQEFGV GDGSKLTLVP TVEAGLMSQA SRPEQSVMQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATAAAGGCT GAGGGCCGCG CGCTTGGCCC AGACCGGCCC GGCCAGCGCG CATTCGGCCC 60
CGGACGAAGG TACTCGCAGC ACTTGGAGCG CAGAACCGGC CGCGCCCGGT GAGTGTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion

KEGG

hsa:90007

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001211	Ailuropoda melanoleuca	82.00	3.00e-82	298.00
IUUC-Aca-004280	Anolis carolinensis	65.12	9.00e-45	174.00
IUUC-Aly-006539	Arabidopsis lyrata	34.09	6.00e-03	33.50
IUUC-Ame-011299	Astyanax mexicanus	77.46	2.00e-66	247.00
IUUC-Bta-013082	Bos taurus	76.86	6.00e-159	553.00
IUUC-Cel-018301	Caenorhabditis elegans	26.83	1.00e-03	37.00
IUUC-Cja-019102	Callithrix jacchus	97.00	0.00e+00	652.00
IUUC-Cfa-020096	Canis familiaris	89.13	9.00e-179	619.00
IUUC-Cpo-022290	Cavia porcellus	81.45	1.00e-159	556.00
IUUC-Csa-023581	Chlorocebus sabaeus	98.51	0.00e+00	639.00
IUUC-Cin-025582	Ciona intestinalis	51.06	8.00e-36	144.00
IUUC-Csv-025994	Ciona savignyi	52.38	9.00e-36	144.00
IUUC-Dre-027459	Danio rerio	67.12	9.00e-67	248.00
IUUC-Dor-030604	Dipodomys ordii	92.84	3.00e-145	508.00
IUUC-Dme-031978	Drosophila melanogaster	50.37	6.00e-30	126.00
IUUC-Eca-034126	Equus caballus	82.54	1.00e-75	275.00
IUUC-Fal-037190	Ficedula albicollis	72.86	4.00e-62	232.00
IUUC-Fso-038183	Fusarium solani	33.90	2.60e-01	32.00
IUUC-Gmo-039292	Gadus morhua	78.53	2.00e-66	245.00
IUUC-Gga-040242	Gallus gallus	63.33	5.00e-126	444.00
IUUC-Gac-042379	Gasterosteus aculeatus	76.51	1.00e-64	239.00
IUUC-Gma-043175	Glycine max	37.33	8.00e-06	42.00
IUUC-Ggo-045533	Gorilla gorilla	88.42	7.00e-156	543.00
IUUC-Itr-048112	Ictidomys tridecemlineatus	82.86	6.00e-136	477.00
IUUC-Lch-050469	Latimeria chalumnae	56.16	6.00e-125	441.00
IUUC-Loc-051781	Lepisosteus oculatus	79.08	2.00e-59	223.00
IUUC-Mcc-055441	Macaca mulatta	92.94	9.00e-149	520.00
IUUC-Meu-056379	Macropus eugenii	64.00	1.00e-115	410.00
IUUC-Mtr-057978	Medicago truncatula	31.17	2.00e-04	37.40
IUUC-Mdo-061920	Monodelphis domestica	85.19	3.00e-60	225.00
IUUC-Mmu-063828	Mus musculus	82.30	5.00e-169	587.00
IUUC-Mpu-066091	Mustela putorius furo	88.06	8.00e-176	610.00
IUUC-Mlu-067919	Myotis lucifugus	93.48	5.00e-20	91.70
IUUC-Nle-069450	Nomascus leucogenys	86.78	4.00e-94	338.00
IUUC-Opr-070444	Ochotona princeps	77.90	3.00e-92	331.00
IUUC-Ont-071842	Oreochromis niloticus	77.71	2.00e-64	240.00
IUUC-Ola-087286	Oryzias latipes	61.76	3.00e-57	216.00
IUUC-Oga-088735	Otolemur garnettii	87.66	8.00e-173	600.00
IUUC-Oar-089367	Ovis aries	77.75	9.00e-115	406.00
IUUC-Pan-092335	Papio anubis	89.44	3.00e-165	574.00
IUUC-Psi-093850	Pelodiscus sinensis	44.14	3.00e-55	209.00
IUUC-Pfo-096547	Poecilia formosa	73.37	1.00e-64	240.00
IUUC-Pab-097811	Pongo abelii	96.03	6.00e-138	483.00
IUUC-Pop-099759	Populus trichocarpa	33.33	1.00e-04	37.40
IUUC-Pca-100261	Procavia capensis	72.61	2.00e-132	465.00
IUUC-Pva-102408	Pteropus vampyrus	88.25	7.00e-175	607.00
IUUC-Rno-105442	Rattus norvegicus	81.71	2.00e-170	592.00
IUUC-Sly-110979	Solanum lycopersicum	32.05	3.00e-05	40.40
IUUC-Stu-112279	Solanum tuberosum	34.67	2.00e-05	40.40
IUUC-Ssc-115388	Sus scrofa	83.41	1.00e-128	453.00
IUUC-Tgu-116546	Taeniopygia guttata	60.58	9.00e-92	330.00
IUUC-Tru-118322	Takifugu rubripes	76.51	5.00e-64	238.00
IUUC-Tni-120877	Tetraodon nigroviridis	68.60	3.00e-62	233.00
IUUC-Ttr-128596	Tursiops truncatus	83.79	4.00e-142	497.00
IUUC-Xtr-132534	Xenopus tropicalis	58.08	3.00e-112	398.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence