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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046308
UUCD1 version UUC-HoS-00671
Ensembl Protein ID ENSP00000354724.5
UniProt Accession Q3KNV8; D3DVN1; O15262; PCGF3_HUMAN
Genbank Protein ID CAA04477.1; EAW82652.1; EAW82653.1; EAW82656.1; AAI07062.1
Protein Name Polycomb group RING finger protein 3; RING finger protein 3A
Genbank Nucleotide ID AJ001019; CH471131; CH471131; CH471131; BC107061
Gene Name PCGF3; RNF3; RNF3A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000185619.18 ENST00000362003.9 ENSP00000354724.5
ENSG00000185619.18 ENST00000400151.6 ENSP00000383015.2
ENSG00000185619.18 ENST00000430644.5 ENSP00000402946.1
ENSG00000185619.18 ENST00000620529.1 ENSP00000479441.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/RAWUL RAWUL 21282530; 22325352; 23523425
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.90e-06 28.4 17 56
ULD/UDP/UFD/RAWUL 8.40e-27 95.2 155 236
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   + d + v+ C H+f+++Cl k+         + +CP+Cr
   Q: 17   CRLCSGYLIDATTVTECLHTFCRSCLVKY------LEENNTCPTCR 56
           9***9999999999***************......9*********8 PP
   

   ULD/UDP/UFD/RAWUL
   S: 1    islsLeplesnkakddsklkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk.kegpLvLqYr 86
           +s++Le+ +s+k ++   lk+k++rcsa++tV hlkkf+a+kl+lss +e+d+lc++e+L++++tL+++ ++++w+ k++pL+L+Yr
   Q: 155  VSICLEC-NSSKLRG---LKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFV-VVTRWRfKKAPLLLHYR 236
           69*****.9999***...***************************************************.******99********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.
 Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.
Protein Sequence
(Fasta)
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH 60
QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046308|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGCCGCGG GGTGGGAGCC CAGACGCACA CCGCGCATGC TCCGAGCGCG GCGCCCCCGA 60
CGCGGCGCTC GGCTCGGCTC GGGCATTTCC GCCTCTTTGT TTTAAACTCC GGACGGGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046308|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008270--F:zinc ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:10336
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002400 Ailuropoda melanoleuca 97.52 1.00e-135 475.00
IUUC-Apl-004072 Anas platyrhynchos 95.38 1.00e-92 331.00
IUUC-Aca-004484 Anolis carolinensis 95.04 2.00e-133 468.00
IUUC-Aly-005422 Arabidopsis lyrata 40.00 1.00e-12 67.80
IUUC-Ath-007274 Arabidopsis thaliana 40.48 2.00e-12 66.60
IUUC-Ame-011838 Astyanax mexicanus 90.91 1.00e-126 445.00
IUUC-Bta-012853 Bos taurus 80.58 6.00e-112 396.00
IUUC-Bdi-015045 Brachypodium distachyon 44.44 9.00e-13 68.20
IUUC-Bra-017953 Brassica rapa 34.78 6.00e-09 55.50
IUUC-Cel-018403 Caenorhabditis elegans 31.40 6.00e-34 139.00
IUUC-Cja-019195 Callithrix jacchus 82.33 1.00e-114 405.00
IUUC-Cfa-021121 Canis familiaris 98.35 4.00e-142 497.00
IUUC-Cpo-021904 Cavia porcellus 97.11 7.00e-134 469.00
IUUC-Cre-022788 Chlamydomonas reinhardtii 31.17 1.00e-07 51.20
IUUC-Csa-024029 Chlorocebus sabaeus 100.00 2.00e-144 504.00
IUUC-Cin-025711 Ciona intestinalis 49.55 5.00e-55 207.00
IUUC-Csv-026354 Ciona savignyi 49.59 2.00e-60 225.00
IUUC-Dno-029902 Dasypus novemcinctus 97.52 6.00e-136 476.00
IUUC-Dor-030528 Dipodomys ordii 88.48 2.00e-105 375.00
IUUC-Dme-032006 Drosophila melanogaster 55.79 8.00e-77 279.00
IUUC-Eca-033585 Equus caballus 98.76 2.00e-142 498.00
IUUC-Fca-035514 Felis catus 99.17 6.00e-143 499.00
IUUC-Fal-036909 Ficedula albicollis 96.28 1.00e-134 472.00
IUUC-Gmo-039424 Gadus morhua 69.76 2.00e-91 328.00
IUUC-Gga-040513 Gallus gallus 96.69 2.00e-135 474.00
IUUC-Gac-041417 Gasterosteus aculeatus 74.49 3.00e-88 317.00
IUUC-Ggo-044870 Gorilla gorilla 100.00 2.00e-144 504.00
IUUC-Hvu-047653 Hordeum vulgare 43.66 6.00e-11 62.40
IUUC-Itr-048221 Ictidomys tridecemlineatus 95.45 2.00e-132 464.00
IUUC-Lpe-051152 Leersia perrieri 47.89 1.00e-11 64.70
IUUC-Loc-052499 Lepisosteus oculatus 91.02 2.00e-127 447.00
IUUC-Laf-053480 Loxodonta africana 98.35 5.00e-142 496.00
IUUC-Mcc-054829 Macaca mulatta 100.00 2.00e-144 504.00
IUUC-Meu-056337 Macropus eugenii 76.96 1.00e-89 322.00
IUUC-Mtr-057854 Medicago truncatula 41.98 4.00e-11 62.40
IUUC-Mga-059490 Meleagris gallopavo 93.72 1.00e-110 392.00
IUUC-Mmr-061326 Microcebus murinus 97.11 7.00e-135 472.00
IUUC-Mdo-062485 Monodelphis domestica 97.94 5.00e-136 476.00
IUUC-Mmu-063919 Mus musculus 97.52 4.00e-134 470.00
IUUC-Mpu-066589 Mustela putorius furo 99.17 6.00e-143 499.00
IUUC-Nle-069442 Nomascus leucogenys 100.00 2.00e-144 504.00
IUUC-Opr-070753 Ochotona princeps 74.38 1.00e-92 332.00
IUUC-Ont-072514 Oreochromis niloticus 90.91 3.00e-124 437.00
IUUC-Oan-073034 Ornithorhynchus anatinus 83.40 4.00e-120 423.00
IUUC-Ocu-074720 Oryctolagus cuniculus 97.11 3.00e-135 474.00
IUUC-Obr-076192 Oryza brachyantha 45.07 7.00e-12 65.10
IUUC-Oin-079944 Oryza indica 46.48 3.00e-11 63.20
IUUC-Oni-082107 Oryza nivara 35.35 1.00e-09 57.40
IUUC-Opu-083871 Oryza punctata 45.07 9.00e-12 65.10
IUUC-Ola-087347 Oryzias latipes 90.08 9.00e-123 432.00
IUUC-Oga-088901 Otolemur garnettii 97.11 7.00e-135 472.00
IUUC-Ptr-090761 Pan troglodytes 99.59 1.00e-135 475.00
IUUC-Pan-092617 Papio anubis 100.00 2.00e-144 504.00
IUUC-Psi-093117 Pelodiscus sinensis 97.53 2.00e-135 474.00
IUUC-Pfo-096724 Poecilia formosa 91.32 1.00e-124 438.00
IUUC-Pab-097921 Pongo abelii 99.59 1.00e-135 474.00
IUUC-Pca-100156 Procavia capensis 98.24 7.00e-133 466.00
IUUC-Pva-102841 Pteropus vampyrus 98.50 1.00e-116 411.00
IUUC-Ptt-103843 Puccinia triticina 40.38 1.00e-05 44.30
IUUC-Rno-105088 Rattus norvegicus 97.52 4.00e-134 470.00
IUUC-Sha-107034 Sarcophilus harrisii 97.53 1.00e-135 475.00
IUUC-Sit-110108 Setaria italica 43.66 5.00e-11 62.40
IUUC-Sar-113067 Sorex araneus 66.50 1.00e-68 252.00
IUUC-Ssc-115483 Sus scrofa 97.50 3.00e-110 390.00
IUUC-Tgu-116929 Taeniopygia guttata 96.28 9.00e-135 472.00
IUUC-Tca-121638 Theobroma cacao 40.74 3.00e-11 63.20
IUUC-Tbe-127854 Tupaia belangeri 80.17 2.00e-102 365.00
IUUC-Ttr-128958 Tursiops truncatus 92.98 6.00e-127 446.00
IUUC-Vvi-131533 Vitis vinifera 40.74 9.00e-11 61.60
IUUC-Xtr-131955 Xenopus tropicalis 87.40 2.00e-120 424.00
IUUC-Xma-133504 Xiphophorus maculatus 91.32 1.00e-124 438.00
Created Date 25-Jun-2017

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