iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106476

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01072688

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000013963.1	ENSSHAT00000016548.1	ENSSHAP00000016411.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.00e-15	54.8	357	404
E3 adaptor/Cullin RING/DCX/DWD	2.60e-34	115.9	152	186
UBD/Beta-Prp	2.30e-48	165.1	126	361

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 357  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 404
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtl.lvsGsdDgtikvWDlrt 32
           gH+d v++l+f  s++l lvs+s+D+t+++WDl +
   Q: 152  GHQDVVRDLSFtpSGNLiLVSASRDKTLRIWDLNK 186
           8***********5445537*************965 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+ +gk++++l+gh + v+++s+sp+ + l 
   Q: 126  ILATGLNDGQIKIWEVQTGRLLLNLSGHQDVVRDLSFTPSGNlILVSASRDKTLRIWDLNkDGKQIQVLSGHLQWVYCCSISPDCSMLC 214
           79*********************************************************989*********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lrtl           +  h +s +s+ f
   Q: 215  SAAGEKSVLLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGEKLRTLqhvldsqldytRDVHASSLRSVRF 302
           ********************.**************************************************99999888999999999* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++      +  +n ++  f+p++ ++++g+ Dg +++W
   Q: 303  SPEGLYLATVADDRLLRIWALELKT--PVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFW 361
           *********************9886..56789999************************** PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

SPDLREVPLL LAELKPGRPH QFDWKSSCET WSVAFSPDGS WFAWSQGHCI VKLIPWPLEE 60
QFIPRGFEPK SRSSKTDPKG RGSPKEKTLD CGQIVWGLAF SPWPSPPSRK LWARVCPQAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCCAGACC TCAGAGGTGC GTAATCCACC CCCTCATTTC ACAGATGAGG AAACAGGCCC 60
AGAGGGGAGG AGTGACCTGG CTAGGGTCAC ATGAGTGGGC TTTTCACACC TTACCTGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	91.81	0.00e+00	747.00
IUUC-Apl-004107	Anas platyrhynchos	69.27	1.00e-132	465.00
IUUC-Aca-004354	Anolis carolinensis	72.64	2.00e-165	575.00
IUUC-Bta-012627	Bos taurus	91.84	0.00e+00	711.00
IUUC-Cja-018897	Callithrix jacchus	91.00	0.00e+00	722.00
IUUC-Cfa-020122	Canis familiaris	92.06	0.00e+00	748.00
IUUC-Cpo-022540	Cavia porcellus	91.84	0.00e+00	733.00
IUUC-Csa-023719	Chlorocebus sabaeus	91.52	0.00e+00	724.00
IUUC-Cho-024367	Choloepus hoffmanni	91.64	5.00e-157	546.00
IUUC-Dno-029021	Dasypus novemcinctus	92.35	0.00e+00	734.00
IUUC-Dor-030321	Dipodomys ordii	91.77	0.00e+00	724.00
IUUC-Ete-032955	Echinops telfairi	92.23	0.00e+00	721.00
IUUC-Eca-033485	Equus caballus	92.60	0.00e+00	707.00
IUUC-Fca-035389	Felis catus	92.05	0.00e+00	728.00
IUUC-Fal-037184	Ficedula albicollis	85.87	8.00e-145	505.00
IUUC-Gga-041014	Gallus gallus	78.80	4.00e-177	613.00
IUUC-Ggo-045585	Gorilla gorilla	91.84	0.00e+00	733.00
IUUC-Hsa-046344	Homo sapiens	91.84	0.00e+00	733.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	92.31	0.00e+00	729.00
IUUC-Lch-050131	Latimeria chalumnae	69.78	2.00e-166	578.00
IUUC-Loc-052807	Lepisosteus oculatus	53.57	8.00e-118	417.00
IUUC-Laf-053528	Loxodonta africana	92.60	0.00e+00	715.00
IUUC-Mcc-055665	Macaca mulatta	91.84	0.00e+00	733.00
IUUC-Meu-056054	Macropus eugenii	95.71	0.00e+00	765.00
IUUC-Mga-059326	Meleagris gallopavo	78.70	0.00e+00	637.00
IUUC-Mmr-060815	Microcebus murinus	91.07	0.00e+00	726.00
IUUC-Mdo-062000	Monodelphis domestica	98.00	0.00e+00	806.00
IUUC-Mmu-063927	Mus musculus	92.56	0.00e+00	730.00
IUUC-Mpu-065726	Mustela putorius furo	90.75	0.00e+00	717.00
IUUC-Mlu-067527	Myotis lucifugus	93.33	7.00e-113	399.00
IUUC-Nle-069680	Nomascus leucogenys	91.58	0.00e+00	726.00
IUUC-Opr-070356	Ochotona princeps	92.48	0.00e+00	745.00
IUUC-Oan-073647	Ornithorhynchus anatinus	84.31	1.00e-135	475.00
IUUC-Ocu-073973	Oryctolagus cuniculus	92.60	0.00e+00	736.00
IUUC-Oga-088797	Otolemur garnettii	91.60	0.00e+00	727.00
IUUC-Oar-089187	Ovis aries	91.84	0.00e+00	711.00
IUUC-Ptr-091317	Pan troglodytes	91.84	0.00e+00	732.00
IUUC-Pan-092694	Papio anubis	84.20	4.00e-179	620.00
IUUC-Psi-093392	Pelodiscus sinensis	80.65	0.00e+00	640.00
IUUC-Pab-098145	Pongo abelii	91.52	0.00e+00	725.00
IUUC-Pca-100454	Procavia capensis	83.46	0.00e+00	659.00
IUUC-Pva-102986	Pteropus vampyrus	83.96	0.00e+00	662.00
IUUC-Rno-104931	Rattus norvegicus	90.49	0.00e+00	714.00
IUUC-Ssc-115643	Sus scrofa	92.27	0.00e+00	727.00
IUUC-Tgu-117522	Taeniopygia guttata	63.26	1.00e-135	476.00
IUUC-Tsy-119301	Tarsius syrichta	92.23	0.00e+00	745.00
IUUC-Tni-120198	Tetraodon nigroviridis	49.52	4.00e-108	384.00
IUUC-Ttr-128683	Tursiops truncatus	92.29	0.00e+00	726.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence