iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004764

UUCD1 version

UUC-AnC-00451

Ensembl Protein ID

ENSACAP00000000240.2

UniProt Accession

G1K8E1; G1K8E1_ANOCA

Protein Name

Uncharacterized protein

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000000212.3	ENSACAT00000000246.3	ENSACAP00000000240.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.80e-179	597.2	65	666

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+n+c++k++  lY++l++v+e+++ +q+     +s d+   Lk++n++W+++++q+ ++r+if
   Q: 65   KLHEAVRAIQTSTSIKYNLEELYQAVENVCSYKASPTLYRQLRQVCEDHVkAQILLFSTDSLDSVlSLKKINKCWQDHCRQMIMIRSIF 153
           5899**********************************************99*************88********************** PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r +i++d  +++++++ +l lie+eR+geavdr+ll+++ ++l++L     ++yk+sFE +fle
   Q: 154  LFLDRTYVLQNSMLPSIWDMGLELFRSHIISDklVQTKTIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKDSFEPRFLE 237
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
            t+++y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++m +L+
   Q: 238  DTNRLYTAEGQRLMQEREVPEYLHHVNKRLEEEADRVVTYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDNLLDENRIADLTQMCQLF 326
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll+ ++++ik+ g+++++++ek+kd   +V++ll++k+k++++++ +F++++k ++ ++++fetf+nk+     +++p E
   Q: 327  SRVKGGQQLLLQYWSEYIKNFGTTIVVNPEKDKD---MVQELLDFKDKVDHIIEVCFQKNEKCINLMKESFETFINKR-----PNKPaE 407
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 408  LIAKYVDSKLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 496
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFk...eekentees..esvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelk 523
           d+++S+d++ qFk    + +n  ++  +  ++   v   g+  t+s +   s+P++    + +  ++   +  g  L+ q t     + 
   Q: 497  DMELSKDIMVQFKqeyVNLQNPIAQprTPKSIRKGVSHLGCCYTYSYKILQSIPEKNLLEFTIAGTYHIGHSLGTYLTSQPTILPHIIS 585
           *************444334555555224456666677788888887777678888888888888888899999**************** PP
   S: 524  aelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
            ++k gk+e+qVs fQ++v L+fn+ +++s+ee+k+at+++e+eL+rtlqsL+++k++vl+k+p +k++e++d+f++N +f
   Q: 586  NTIKGGKKEFQVSLFQTLVFLMFNDGDEFSFEEIKMATGIEESELKRTLQSLACGKARVLNKSPRGKDVEDGDKFIFNADF 666
           ******************************************************************************998 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAGEPQKKQQ QRHLSALVGH TNGLTKPASL AGGRSGAVAS KKLIIKNFRE RPTLPDNYTR 60
ETWQKLHEAV RAIQTSTSIK YNLEELYQAV ENVCSYKASP TLYRQLRQVC EDHVKAQILL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTTCTTTA GCGCAGGATT CAATGGCACC GAGCCATGGC TTTGCAAGCG GTGCCAAACC 60
GCGCCAGTCC CAGCGTGTAG GAGGCGCCCG CTCTGTCCCG CCGTGATCCC TCCTTTCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0030097--P:hemopoiesis
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Meu-056492	Macropus eugenii	72.54	2.00e-166	579.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence