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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046879
UUCD1 version UUC-HoS-00191
Ensembl Protein ID ENSP00000340648.3
UniProt Accession Q7Z6Z7; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9; HUWE1_HUMAN
Genbank Protein ID AAV90838.1; AAY98258.1; AAX24125.1; CAI39580.1; CAI39580.1; CAI39580.1; CAI42354.1; CAI42354.1; CAI42354.1; CAI42654.1; CAI42654.1; CAI42654.1; BAC06833.1; BAA20771.3; BAB13404.1; AAF28950.1; AAH02602.2; AAH63505.1; AAC62492.1; CAG33094.1; CAB82393.1
Protein Name E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Homologous to E6AP carboxyl terminus homologous protein 9; Large structure of UREB1; Mcl-1 ubiquitin ligase E3; Upstream regulatory element-binding protein 1
Genbank Nucleotide ID AY772009; DQ097177; AY929612; AL592046; Z94044; Z97054; Z94044; AL592046; Z97054; Z97054; AL592046; Z94044; AB071605; AB002310; AB046798; AF161390; BC002602; BC063505; AF057569; CR456813; AL162050
Gene Name HUWE1; KIAA0312; KIAA1578; UREB1; HSPC272
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000086758.15 ENST00000426907.5 ENSP00000403236.1
ENSG00000086758.15 ENST00000612484.4 ENSP00000479451.1
ENSG00000086758.15 ENST00000342160.7 ENSP00000340648.3
ENSG00000086758.15 ENST00000468322.2 ENSP00000483891.1
ENSG00000086758.15 ENST00000622887.1 ENSP00000484417.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 18617514; 20007713; 18923429; 18923429; 18488021; 19713937; 20210701; 16213503; 20624960; 25147182
UBD/Alpha-Helix/UBA UBA 15567145; 15989957; 19713937
Classification
Family E-value Score Start End
E3 activity/HECT 1.70e-121 407.4 4039 4373
UBD/Alpha-Helix/UBA 1.90e-07 32.7 1318 1355
Active Site
Position(s) Description Evidence
4341 Glycyl thioester intermediate N/A
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll++ 
   Q: 4039 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLLECY 4127
           6799*******************************************************86.99************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+lv+++r
   Q: 4128 FTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMR 4214
           **********************************99...*************************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgs 271
           ++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r++fLqFvTg+
   Q: 4215 MTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGT 4303
           ******************************************************66.********************************* PP
   S: 272  srlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 4304 SKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 4373
           ************99998999999988899***************************************97 PP
   

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1318 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1355
           89**********************.7***********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.
 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.
Protein Sequence
(Fasta)
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046879|E3,HECT;UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGGCTTTC GACTGAGGGC TAGCGAGGGG AGCAGGGCTG GAGCAGGGCT GGAGCAGGGC 60
TGGAGCAGGG CTGAAGCAGG GCTGAAGCAG GGCCGCGGAC CCCGCACGCT CCTGCGGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046879|E3,HECT;UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0991--Mental retardation
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE
Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE
SMART

SM00119--HECTc
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0034774--C:secretory granule lumen
GO:0003677--F:DNA binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0030154--P:cell differentiation
GO:0016574--P:histone ubiquitination
GO:0043312--P:neutrophil degranulation
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
KEGG hsa:10075
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000627 Aegilops tauschii 46.95 3.00e-106 382.00
IUUC-Aml-001684 Ailuropoda melanoleuca 99.34 0.00e+00 4435.00
IUUC-Atr-003044 Amborella trichopoda 52.69 8.00e-126 447.00
IUUC-Apl-003729 Anas platyrhynchos 93.54 0.00e+00 696.00
IUUC-Aca-005263 Anolis carolinensis 92.60 0.00e+00 3133.00
IUUC-Aly-006083 Arabidopsis lyrata 51.77 3.00e-126 448.00
IUUC-Ath-007472 Arabidopsis thaliana 51.77 2.00e-126 449.00
IUUC-Ago-008005 Ashbya gossypii 46.53 4.00e-131 464.00
IUUC-Acl-008254 Aspergillus clavatus 46.46 6.00e-134 474.00
IUUC-Afl-008712 Aspergillus flavus 45.57 1.00e-135 478.00
IUUC-Afu-009022 Aspergillus fumigatus 46.27 2.00e-133 472.00
IUUC-Ani-009412 Aspergillus nidulans 46.83 2.00e-135 478.00
IUUC-Ang-009771 Aspergillus niger 46.83 3.00e-134 475.00
IUUC-Aor-010186 Aspergillus oryzae 44.74 3.00e-126 446.00
IUUC-Ate-010253 Aspergillus terreus 46.99 2.00e-134 475.00
IUUC-Ame-011067 Astyanax mexicanus 81.00 0.00e+00 3666.00
IUUC-Bgr-012043 Blumeria graminis 46.62 4.00e-139 491.00
IUUC-Bta-012813 Bos taurus 98.92 0.00e+00 4462.00
IUUC-Bci-013995 Botrytis cinerea 45.97 1.00e-137 486.00
IUUC-Bdi-014884 Brachypodium distachyon 51.99 5.00e-127 451.00
IUUC-Bol-016533 Brassica oleracea 58.33 6.00e-89 320.00
IUUC-Bra-016637 Brassica rapa 44.36 4.00e-123 438.00
IUUC-Cel-018179 Caenorhabditis elegans 61.52 0.00e+00 646.00
IUUC-Cja-018741 Callithrix jacchus 99.50 0.00e+00 4458.00
IUUC-Cfa-020083 Canis familiaris 97.51 0.00e+00 4429.00
IUUC-Cpo-021923 Cavia porcellus 98.09 0.00e+00 4392.00
IUUC-Cre-022900 Chlamydomonas reinhardtii 48.83 1.00e-119 423.00
IUUC-Csa-023853 Chlorocebus sabaeus 99.67 0.00e+00 4458.00
IUUC-Cho-024718 Choloepus hoffmanni 100.00 0.00e+00 815.00
IUUC-Cin-025627 Ciona intestinalis 42.86 0.00e+00 1933.00
IUUC-Csv-025824 Ciona savignyi 48.10 0.00e+00 1447.00
IUUC-Cgl-026647 Colletotrichum gloeosporioides 53.11 3.00e-136 481.00
IUUC-Cne-027095 Cryptococcus neoformans 41.51 4.00e-105 378.00
IUUC-Cme-027267 Cyanidioschyzon merolae 50.00 1.00e-115 412.00
IUUC-Dre-028525 Danio rerio 82.12 0.00e+00 3650.00
IUUC-Dno-029680 Dasypus novemcinctus 98.34 0.00e+00 4371.00
IUUC-Dor-030902 Dipodomys ordii 96.20 0.00e+00 1216.00
IUUC-Dse-031197 Dothistroma septosporum 47.12 4.00e-138 488.00
IUUC-Dme-032122 Drosophila melanogaster 68.19 0.00e+00 792.00
IUUC-Ete-032690 Echinops telfairi 90.76 0.00e+00 1257.00
IUUC-Eca-033915 Equus caballus 98.79 0.00e+00 4411.00
IUUC-Eeu-034963 Erinaceus europaeus 93.82 0.00e+00 2964.00
IUUC-Fca-035824 Felis catus 99.29 0.00e+00 4444.00
IUUC-Fox-037756 Fusarium oxysporum 53.53 6.00e-137 484.00
IUUC-Fso-038464 Fusarium solani 54.48 1.00e-136 483.00
IUUC-Gmo-039073 Gadus morhua 83.05 0.00e+00 3660.00
IUUC-Ggr-039946 Gaeumannomyces graminis 52.98 3.00e-134 475.00
IUUC-Gga-040309 Gallus gallus 98.38 0.00e+00 654.00
IUUC-Gac-042430 Gasterosteus aculeatus 83.40 0.00e+00 3744.00
IUUC-Gma-043129 Glycine max 47.50 4.00e-126 447.00
IUUC-Ggo-044785 Gorilla gorilla 99.96 0.00e+00 4428.00
IUUC-Hvu-047697 Hordeum vulgare 44.99 1.00e-127 452.00
IUUC-Itr-048430 Ictidomys tridecemlineatus 99.26 0.00e+00 1484.00
IUUC-Kpa-049228 Komagataella pastoris 48.78 8.00e-141 496.00
IUUC-Lch-050252 Latimeria chalumnae 88.90 0.00e+00 3373.00
IUUC-Lpe-051550 Leersia perrieri 51.99 8.00e-127 450.00
IUUC-Loc-052472 Lepisosteus oculatus 83.72 0.00e+00 3759.00
IUUC-Lma-053159 Leptosphaeria maculans 45.69 5.00e-136 481.00
IUUC-Laf-054154 Loxodonta africana 98.34 0.00e+00 4402.00
IUUC-Mcc-055085 Macaca mulatta 98.03 0.00e+00 4406.00
IUUC-Meu-056727 Macropus eugenii 94.43 0.00e+00 1912.00
IUUC-Mor-057201 Magnaporthe oryzae 46.49 6.00e-135 477.00
IUUC-Mpo-057597 Magnaporthe poae 46.11 5.00e-133 471.00
IUUC-Mtr-058273 Medicago truncatula 52.46 2.00e-126 449.00
IUUC-Mla-058888 Melampsora laricipopulina 49.12 4.00e-116 411.00
IUUC-Mvi-060320 Microbotryum violaceum 40.95 3.00e-123 438.00
IUUC-Mmr-060820 Microcebus murinus 97.16 0.00e+00 4375.00
IUUC-Mdo-062930 Monodelphis domestica 91.97 0.00e+00 4148.00
IUUC-Mmu-063601 Mus musculus 98.55 0.00e+00 4295.00
IUUC-Mac-065557 Musa acuminata 52.09 5.00e-119 424.00
IUUC-Mpu-066653 Mustela putorius furo 97.38 0.00e+00 4314.00
IUUC-Mlu-067418 Myotis lucifugus 98.34 0.00e+00 4480.00
IUUC-Nfi-068278 Neosartorya fischeri 46.46 6.00e-134 474.00
IUUC-Ncr-068813 Neurospora crassa 46.68 4.00e-136 481.00
IUUC-Nle-069418 Nomascus leucogenys 99.58 0.00e+00 4398.00
IUUC-Opr-070187 Ochotona princeps 84.51 0.00e+00 888.00
IUUC-Ont-071300 Oreochromis niloticus 83.74 0.00e+00 3711.00
IUUC-Oan-073046 Ornithorhynchus anatinus 88.62 0.00e+00 5299.00
IUUC-Ocu-074178 Oryctolagus cuniculus 98.75 0.00e+00 4469.00
IUUC-Oba-075757 Oryza barthii 51.76 7.00e-127 450.00
IUUC-Obr-076553 Oryza brachyantha 45.17 6.00e-126 447.00
IUUC-Ogl-077520 Oryza glaberrima 51.76 7.00e-127 450.00
IUUC-Ogu-078278 Oryza glumaepatula 51.76 6.00e-127 450.00
IUUC-Oin-079767 Oryza indica 51.76 6.00e-127 450.00
IUUC-Olo-080380 Oryza longistaminata 51.28 4.00e-125 444.00
IUUC-Ome-081925 Oryza meridionalis 51.28 3.00e-125 444.00
IUUC-Oni-082619 Oryza nivara 51.76 7.00e-127 450.00
IUUC-Opu-083684 Oryza punctata 51.28 3.00e-125 445.00
IUUC-Oru-084501 Oryza rufipogon 51.76 6.00e-127 450.00
IUUC-Osa-086251 Oryza sativa 51.76 2.00e-125 442.00
IUUC-Ola-087437 Oryzias latipes 85.32 0.00e+00 2135.00
IUUC-Olu-087813 Ostreococcus lucimarinus 50.50 8.00e-114 403.00
IUUC-Oga-088903 Otolemur garnettii 99.13 0.00e+00 4401.00
IUUC-Oar-090210 Ovis aries 97.31 0.00e+00 4409.00
IUUC-Ptr-090502 Pan troglodytes 100.00 0.00e+00 3419.00
IUUC-Pan-092368 Papio anubis 99.69 0.00e+00 3445.00
IUUC-Pma-094246 Petromyzon marinus 74.50 0.00e+00 1295.00
IUUC-Pno-094871 Phaeosphaeria nodorum 52.76 1.00e-134 476.00
IUUC-Ppa-095657 Physcomitrella patens 51.36 3.00e-125 445.00
IUUC-Pfo-096232 Poecilia formosa 80.96 0.00e+00 3678.00
IUUC-Pab-098583 Pongo abelii 99.96 0.00e+00 4432.00
IUUC-Pop-099613 Populus trichocarpa 53.16 4.00e-128 454.00
IUUC-Pca-100310 Procavia capensis 83.93 0.00e+00 1659.00
IUUC-Ppe-102109 Prunus persica 52.46 1.00e-126 449.00
IUUC-Pva-102116 Pteropus vampyrus 98.96 0.00e+00 4474.00
IUUC-Pgr-103465 Puccinia graminis 43.29 2.00e-127 452.00
IUUC-Ptt-103813 Puccinia triticina 41.21 6.00e-115 410.00
IUUC-Pte-104018 Pyrenophora teres 52.53 3.00e-133 471.00
IUUC-Pyt-104713 Pyrenophora triticirepentis 52.41 3.00e-133 471.00
IUUC-Rno-105889 Rattus norvegicus 90.67 0.00e+00 3889.00
IUUC-Sce-106449 Saccharomyces cerevisiae 45.11 2.00e-126 449.00
IUUC-Sha-106961 Sarcophilus harrisii 90.45 0.00e+00 4093.00
IUUC-Sja-107814 Schizosaccharomyces japonicus 45.54 5.00e-128 454.00
IUUC-Spo-108024 Schizosaccharomyces pombe 45.24 1.00e-130 462.00
IUUC-Smo-109428 Selaginella moellendorffii 51.10 1.00e-130 462.00
IUUC-Sit-110598 Setaria italica 52.46 1.00e-127 452.00
IUUC-Sly-111285 Solanum lycopersicum 51.67 8.00e-128 453.00
IUUC-Stu-112582 Solanum tuberosum 32.35 5.00e-57 216.00
IUUC-Sar-113291 Sorex araneus 93.28 0.00e+00 2753.00
IUUC-Sbi-114042 Sorghum bicolor 52.46 7.00e-128 453.00
IUUC-Sre-114958 Sporisorium reilianum 56.50 8.00e-139 487.00
IUUC-Ssc-115754 Sus scrofa 99.46 0.00e+00 4447.00
IUUC-Tru-118570 Takifugu rubripes 83.11 0.00e+00 3763.00
IUUC-Tsy-119159 Tarsius syrichta 92.80 0.00e+00 2094.00
IUUC-Tni-120836 Tetraodon nigroviridis 77.63 0.00e+00 2005.00
IUUC-Tca-121479 Theobroma cacao 51.29 1.00e-124 442.00
IUUC-Tre-121909 Trichoderma reesei 53.41 6.00e-133 470.00
IUUC-Tvi-122370 Trichoderma virens 53.18 6.00e-133 470.00
IUUC-Tae-125214 Triticum aestivum 51.04 2.00e-125 444.00
IUUC-Tme-127172 Tuber melanosporum 46.99 4.00e-139 491.00
IUUC-Tbe-127506 Tupaia belangeri 96.15 0.00e+00 1504.00
IUUC-Ttr-129253 Tursiops truncatus 91.48 0.00e+00 2204.00
IUUC-Uma-129355 Ustilago maydis 49.06 4.00e-141 494.00
IUUC-Vda-129886 Verticillium dahliae 47.44 2.00e-138 489.00
IUUC-Vpa-130708 Vicugna pacos 97.65 0.00e+00 3883.00
IUUC-Vvi-131170 Vitis vinifera 51.00 7.00e-127 449.00
IUUC-Xtr-132123 Xenopus tropicalis 84.54 0.00e+00 6394.00
IUUC-Xma-133869 Xiphophorus maculatus 81.02 0.00e+00 3690.00
IUUC-Yli-134657 Yarrowia lipolytica 45.44 4.00e-130 461.00
IUUC-Zma-135570 Zea mays 44.58 3.00e-128 455.00
Created Date 25-Jun-2017

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