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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045798
UUCD1 version UUC-HoS-00272
Ensembl Protein ID ENSP00000326170.7
UniProt Accession Q8WZ73; E1P633; Q8NHW0; Q8TBY7; Q96BE6; RFFL_HUMAN
Genbank Protein ID AAL30771.1; AAM29181.1; BAC04059.1; CAI45952.1; EAW80172.1; EAW80173.1; EAW80176.1; EAW80177.1; EAW80178.1; AAH15681.2; AAH28424.1
Protein Name E3 ubiquitin-protein ligase rififylin; Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; FYVE-RING finger protein Sakura; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RING-type E3 ubiquitin transferase rififylin
Genbank Nucleotide ID AF434816; AY098935; AK093112; CR933651; CH471147; CH471147; CH471147; CH471147; CH471147; BC015681; BC028424
Gene Name RFFL; RNF189; RNF34L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000092871.16 ENST00000315249.11 ENSP00000326170.7
ENSG00000092871.16 ENST00000584655.5 ENSP00000463035.1
ENSG00000092871.16 ENST00000413582.6 ENSP00000408513.2
ENSG00000092871.16 ENST00000581039.1 ENSP00000462656.1
ENSG00000092871.16 ENST00000582308.1 ENSP00000462499.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18450452; 15069192
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.022 16.9 316 351
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC++++ d  ++l CgH+  +++C           ++   CP+Cr
   Q: 316  CKICMDSPID-CVLLECGHMVtCTKC----------GKRMNECPICR 351
           99********.888*****888****..........777799****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
 E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Protein Sequence
(Fasta)
MWATCCNWFC LDGQPEEVPP PQGARMQAYS NPGYSSFPSP TGLEPSCKSC GAHFANTARK 60
QTCLDCKKNF CMTCSSQVGN GPRLCLLCQR FRATAFQREE LMKMKVKDLR DYLSLHDIST 120
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Protein Fasta Sequence


>IUUC-Hsa-045798|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCCGGGCCG GGCCGGCTGG GGATGGGTGG GAGGGGGGGC CGACTTCCTG GGGCCGCCCG 60
TGAGGATGTC GCGACCGCCC CCGGGTGCCC CTCAGCCCCA GAGACGCCGC CGCGGCGGAG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045798|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0002039--F:p53 binding
GO:0002020--F:protease binding
GO:0019901--F:protein kinase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010762--P:regulation of fibroblast migration
GO:0032006--P:regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:117584
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001630 Ailuropoda melanoleuca 90.63 0.00e+00 637.00
IUUC-Apl-004124 Anas platyrhynchos 66.30 1.00e-125 442.00
IUUC-Aly-005548 Arabidopsis lyrata 47.06 1.00e-08 55.50
IUUC-Ame-011616 Astyanax mexicanus 59.67 9.00e-105 373.00
IUUC-Bta-012374 Bos taurus 85.95 0.00e+00 633.00
IUUC-Cja-019780 Callithrix jacchus 95.33 0.00e+00 688.00
IUUC-Cfa-021252 Canis familiaris 92.56 0.00e+00 647.00
IUUC-Cpo-022047 Cavia porcellus 91.46 0.00e+00 661.00
IUUC-Csa-023161 Chlorocebus sabaeus 98.35 0.00e+00 743.00
IUUC-Cho-024316 Choloepus hoffmanni 91.75 3.00e-157 547.00
IUUC-Cne-026858 Cryptococcus neoformans 25.15 8.00e-07 48.50
IUUC-Dre-028596 Danio rerio 55.92 4.00e-109 387.00
IUUC-Dno-029333 Dasypus novemcinctus 92.84 0.00e+00 670.00
IUUC-Ete-033163 Echinops telfairi 83.75 5.00e-166 577.00
IUUC-Eca-033994 Equus caballus 92.56 0.00e+00 679.00
IUUC-Eeu-035162 Erinaceus europaeus 86.67 4.00e-131 460.00
IUUC-Fca-036418 Felis catus 91.46 0.00e+00 694.00
IUUC-Fal-037427 Ficedula albicollis 65.40 2.00e-133 469.00
IUUC-Gga-041053 Gallus gallus 67.49 6.00e-132 463.00
IUUC-Ggo-045436 Gorilla gorilla 100.00 0.00e+00 755.00
IUUC-Itr-048077 Ictidomys tridecemlineatus 92.01 0.00e+00 649.00
IUUC-Lch-050639 Latimeria chalumnae 62.53 4.00e-126 444.00
IUUC-Laf-053355 Loxodonta africana 89.89 0.00e+00 629.00
IUUC-Mcc-055222 Macaca mulatta 97.80 0.00e+00 687.00
IUUC-Meu-056692 Macropus eugenii 77.96 1.00e-159 555.00
IUUC-Mga-059298 Meleagris gallopavo 66.39 7.00e-131 460.00
IUUC-Mmr-061792 Microcebus murinus 90.08 0.00e+00 641.00
IUUC-Mdo-062986 Monodelphis domestica 81.54 1.00e-170 592.00
IUUC-Mmu-063356 Mus musculus 89.53 0.00e+00 650.00
IUUC-Mpu-066273 Mustela putorius furo 91.74 0.00e+00 694.00
IUUC-Mlu-066953 Myotis lucifugus 91.46 0.00e+00 681.00
IUUC-Nle-070075 Nomascus leucogenys 98.62 0.00e+00 748.00
IUUC-Opr-070838 Ochotona princeps 89.53 0.00e+00 643.00
IUUC-Ont-071967 Oreochromis niloticus 50.96 8.00e-92 330.00
IUUC-Ocu-074807 Oryctolagus cuniculus 90.91 0.00e+00 681.00
IUUC-Obr-076159 Oryza brachyantha 41.07 4.00e-08 50.40
IUUC-Ola-086903 Oryzias latipes 48.40 7.00e-86 310.00
IUUC-Oga-088536 Otolemur garnettii 90.63 0.00e+00 630.00
IUUC-Oar-089838 Ovis aries 86.50 6.00e-179 620.00
IUUC-Ptr-090962 Pan troglodytes 99.72 0.00e+00 755.00
IUUC-Pan-092853 Papio anubis 97.80 0.00e+00 740.00
IUUC-Psi-093164 Pelodiscus sinensis 65.48 3.00e-127 447.00
IUUC-Pma-094104 Petromyzon marinus 44.65 3.00e-57 215.00
IUUC-Pno-094968 Phaeosphaeria nodorum 36.73 2.00e-08 56.20
IUUC-Pab-098304 Pongo abelii 99.17 0.00e+00 749.00
IUUC-Pca-100316 Procavia capensis 89.81 3.00e-178 617.00
IUUC-Ppe-101490 Prunus persica 37.80 1.00e-09 57.80
IUUC-Pva-102612 Pteropus vampyrus 77.96 2.00e-158 551.00
IUUC-Rno-105449 Rattus norvegicus 90.36 0.00e+00 649.00
IUUC-Sha-107578 Sarcophilus harrisii 80.44 4.00e-158 550.00
IUUC-Sar-113638 Sorex araneus 86.23 7.00e-176 609.00
IUUC-Ssc-116401 Sus scrofa 90.63 0.00e+00 685.00
IUUC-Tru-118765 Takifugu rubripes 49.59 1.00e-82 300.00
IUUC-Tsy-118850 Tarsius syrichta 90.43 1.00e-154 538.00
IUUC-Tbe-128086 Tupaia belangeri 85.12 0.00e+00 629.00
IUUC-Ttr-128249 Tursiops truncatus 69.42 4.00e-139 487.00
IUUC-Vpa-130816 Vicugna pacos 87.21 5.00e-41 160.00
Created Date 25-Jun-2017

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