iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004803

Ensembl Protein ID

ENSACAP00000012107.3

UniProt Accession

H9GIS6; H9GIS6_ANOCA

Protein Name

Non-specific serine/threonine protein kinase

Gene Name

MARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012178.3	ENSACAT00000012352.3	ENSACAP00000012107.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	85.93	0.00e+00	1330.00	IUUC-Hsa-046901

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSNSGRSPLP TLTENTEQTA IGHPESKPST KSNMLRGRTP ATSADEQPHI GNYRLLKTIG 60
KGNFAKVKLA RHVLTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 120

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Nucleotide Sequence
(Fasta)

CCAAGTTGGG TTTAAGACAC TTAGGAATTT CCCCTACACT CAGAATACTC ATTCGGTTGT 60
TTCCGTAGAC TCCGAGCTCA ACCCGTTCGG CTATTTCCGT ATTCAGCGAG CCGAAATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc
SM00165--UBA

Gene Ontology

GO:0005884--C:actin filament
GO:0016328--C:lateral plasma membrane
GO:0097427--C:microtubule bundle
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0003723--F:RNA binding
GO:0030010--P:establishment of cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0010976--P:positive regulation of neuron projection development
GO:0050770--P:regulation of axonogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011854	Astyanax mexicanus	65.73	0.00e+00	963.00
IUUC-Cel-018198	Caenorhabditis elegans	74.00	2.00e-161	563.00
IUUC-Cja-019475	Callithrix jacchus	84.52	0.00e+00	1276.00
IUUC-Cfa-020356	Canis familiaris	86.08	0.00e+00	1308.00
IUUC-Cgl-026480	Colletotrichum gloeosporioides	43.01	3.00e-69	256.00
IUUC-Dre-028467	Danio rerio	68.38	0.00e+00	952.00
IUUC-Dno-029653	Dasypus novemcinctus	86.62	0.00e+00	1309.00
IUUC-Dor-030743	Dipodomys ordii	86.92	0.00e+00	1295.00
IUUC-Ete-032528	Echinops telfairi	89.97	0.00e+00	1152.00
IUUC-Eca-033799	Equus caballus	86.89	0.00e+00	1296.00
IUUC-Eeu-034949	Erinaceus europaeus	92.37	0.00e+00	902.00
IUUC-Fca-035596	Felis catus	85.93	0.00e+00	1329.00
IUUC-Gac-042044	Gasterosteus aculeatus	68.79	0.00e+00	934.00
IUUC-Hsa-046901	Homo sapiens	85.93	0.00e+00	1330.00
IUUC-Lch-049551	Latimeria chalumnae	76.84	0.00e+00	1137.00
IUUC-Loc-051934	Lepisosteus oculatus	64.64	0.00e+00	897.00
IUUC-Mcc-055104	Macaca mulatta	85.93	0.00e+00	1330.00
IUUC-Meu-056525	Macropus eugenii	87.71	0.00e+00	1308.00
IUUC-Mmr-060697	Microcebus murinus	86.06	0.00e+00	1330.00
IUUC-Mmu-063467	Mus musculus	85.42	0.00e+00	1285.00
IUUC-Mpu-066665	Mustela putorius furo	87.26	0.00e+00	1318.00
IUUC-Opr-070302	Ochotona princeps	85.28	0.00e+00	1306.00
IUUC-Ont-071386	Oreochromis niloticus	66.50	0.00e+00	905.00
IUUC-Pan-092847	Papio anubis	85.93	0.00e+00	1330.00
IUUC-Pva-103239	Pteropus vampyrus	86.92	0.00e+00	1285.00
IUUC-Pgr-103687	Puccinia graminis	46.18	2.00e-70	260.00
IUUC-Ptt-103944	Puccinia triticina	44.73	5.00e-67	249.00
IUUC-Ssc-116439	Sus scrofa	87.97	0.00e+00	915.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence