iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041777

UUCD1 version

UUC-GaA-00658

Ensembl Protein ID

ENSGACP00000017004.3

UniProt Accession

G3PHC9; G3PHC9_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000012853.3	ENSGACT00000017038.3	ENSGACP00000017004.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-118	395.1	2085	2549

Active Site

Position(s)	Description	Evidence
2518	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2085 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgfyvqrscglfpapfpqdsee 2170
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             +  klF+flG++l+k++qd+rl+dlp s++f+kll                                                  
   Q: 2171 leRISKLFHFLGVFLAKCIQDNRLVDLPVSQPFFKLLcmgdikstmskllyhsrgappghgadrplpflllseasteesqetyslgs 2257
           *************************************99999999999999999999999999999999999999999888888888 PP
   S: 101  .....................lgkklsledleevdpelykslkeikena.......es...........................di 132
                                 +  l+++d++ v+p+++ +lke+ke+a       +s                           +i
   Q: 2258 fdedsksefimdppkpkppawYHGILTWDDFQLVNPHRASFLKEVKELAvkrrqilSSkslcedekntrlqdlmlrnplgsgpplSI 2344
           7777777776666666665555557***********************976665550056666777889999999999999****** PP
   S: 133  eelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellic 219
           e+lgl+++f++s+++ g  +++ Lk++G++++Vt+eN+eeYv+l++++++++gi++q+eafreGfn+v+p+e+ls+F+++e+++++c
   Q: 2345 EDLGLNFQFCPSSKVHGFSAVD-LKTNGDDEMVTMENAEEYVELMLDFCMHTGIQKQMEAFREGFNRVFPMEKLSSFSHKEVQMILC 2430
           ************9988888777.**************************************************************** PP
   S: 220  Ge..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnT 303
           G+  ++++++d+ + t+ k g+t+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nT
   Q: 2431 GNqsPSWTADDIINYTEPKLGFTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDSSYPSVNT 2517
           **6666777777777777********************************************************************* PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFels 336
           C++yLkLPeYss++i++e+Ll+A++e kgF+l+
   Q: 2518 CVHYLKLPEYSSEDIMRERLLAATME-KGFHLN 2549
           **************************.****86 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG TGGACCCAGA CACCCTGCTG GAGTGGCTGC AGATGGGGCA GGGCGACGAG 60
CGGGACATGC AGCTGATCGC TCTGGAGCAG CTCTGCATGC TGCTGCTCAT GTCGGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	86.44	0.00e+00	2562.00
IUUC-Apl-003493	Anas platyrhynchos	86.25	0.00e+00	2571.00
IUUC-Aca-004521	Anolis carolinensis	85.96	0.00e+00	2791.00
IUUC-Ame-011258	Astyanax mexicanus	91.94	0.00e+00	2385.00
IUUC-Bta-012835	Bos taurus	86.20	0.00e+00	2566.00
IUUC-Cel-018153	Caenorhabditis elegans	42.98	5.00e-178	619.00
IUUC-Cja-019174	Callithrix jacchus	85.48	0.00e+00	2510.00
IUUC-Cfa-021115	Canis familiaris	85.85	0.00e+00	2516.00
IUUC-Cpo-022382	Cavia porcellus	80.89	0.00e+00	2347.00
IUUC-Csa-023230	Chlorocebus sabaeus	86.32	0.00e+00	2561.00
IUUC-Cho-024711	Choloepus hoffmanni	89.83	0.00e+00	1142.00
IUUC-Cin-025342	Ciona intestinalis	52.45	0.00e+00	1333.00
IUUC-Csv-026031	Ciona savignyi	51.34	0.00e+00	1370.00
IUUC-Dre-027435	Danio rerio	90.52	0.00e+00	2915.00
IUUC-Dno-029954	Dasypus novemcinctus	86.32	0.00e+00	2563.00
IUUC-Dor-030734	Dipodomys ordii	88.86	0.00e+00	1318.00
IUUC-Dme-031739	Drosophila melanogaster	57.99	0.00e+00	1595.00
IUUC-Ete-033192	Echinops telfairi	85.19	0.00e+00	1124.00
IUUC-Eca-033434	Equus caballus	86.05	0.00e+00	2547.00
IUUC-Eeu-035031	Erinaceus europaeus	77.46	0.00e+00	991.00
IUUC-Fca-035998	Felis catus	83.91	0.00e+00	2460.00
IUUC-Fal-037468	Ficedula albicollis	81.66	0.00e+00	3791.00
IUUC-Gmo-038495	Gadus morhua	93.31	0.00e+00	1368.00
IUUC-Gga-040736	Gallus gallus	82.67	0.00e+00	3793.00
IUUC-Ggo-044677	Gorilla gorilla	82.83	0.00e+00	2401.00
IUUC-Hsa-045879	Homo sapiens	86.32	0.00e+00	2561.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	86.32	0.00e+00	2564.00
IUUC-Lch-050444	Latimeria chalumnae	85.60	0.00e+00	2486.00
IUUC-Loc-051986	Lepisosteus oculatus	85.77	0.00e+00	2820.00
IUUC-Laf-054230	Loxodonta africana	86.35	0.00e+00	2544.00
IUUC-Mcc-054787	Macaca mulatta	86.32	0.00e+00	2561.00
IUUC-Meu-056502	Macropus eugenii	83.64	0.00e+00	1020.00
IUUC-Mga-059409	Meleagris gallopavo	92.82	0.00e+00	1855.00
IUUC-Mmr-061667	Microcebus murinus	85.45	0.00e+00	2550.00
IUUC-Mdo-061960	Monodelphis domestica	86.22	0.00e+00	2561.00
IUUC-Mmu-063941	Mus musculus	85.77	0.00e+00	2541.00
IUUC-Mpu-065939	Mustela putorius furo	86.32	0.00e+00	2562.00
IUUC-Mlu-068112	Myotis lucifugus	86.14	0.00e+00	2558.00
IUUC-Nle-069001	Nomascus leucogenys	86.32	0.00e+00	2561.00
IUUC-Opr-071222	Ochotona princeps	89.09	0.00e+00	1987.00
IUUC-Ont-072101	Oreochromis niloticus	92.40	0.00e+00	4221.00
IUUC-Oan-072814	Ornithorhynchus anatinus	86.44	0.00e+00	2568.00
IUUC-Ocu-074011	Oryctolagus cuniculus	86.38	0.00e+00	2562.00
IUUC-Ola-086412	Oryzias latipes	89.54	0.00e+00	4054.00
IUUC-Oar-089668	Ovis aries	86.20	0.00e+00	2560.00
IUUC-Ptr-090517	Pan troglodytes	86.23	0.00e+00	2538.00
IUUC-Pan-091849	Papio anubis	83.21	0.00e+00	2432.00
IUUC-Psi-093390	Pelodiscus sinensis	80.37	0.00e+00	3676.00
IUUC-Pma-094628	Petromyzon marinus	81.84	0.00e+00	1513.00
IUUC-Pfo-097075	Poecilia formosa	90.23	0.00e+00	4164.00
IUUC-Pab-098176	Pongo abelii	86.32	0.00e+00	2561.00
IUUC-Pca-101123	Procavia capensis	69.67	0.00e+00	1140.00
IUUC-Pva-103008	Pteropus vampyrus	93.61	0.00e+00	1492.00
IUUC-Rno-105885	Rattus norvegicus	85.97	0.00e+00	2554.00
IUUC-Sha-107048	Sarcophilus harrisii	85.93	0.00e+00	2543.00
IUUC-Sar-113071	Sorex araneus	88.20	0.00e+00	1189.00
IUUC-Ssc-115963	Sus scrofa	86.20	0.00e+00	2560.00
IUUC-Tgu-117167	Taeniopygia guttata	75.65	0.00e+00	1289.00
IUUC-Tru-118626	Takifugu rubripes	91.21	0.00e+00	4244.00
IUUC-Tsy-119504	Tarsius syrichta	82.31	0.00e+00	2027.00
IUUC-Tni-119877	Tetraodon nigroviridis	91.14	0.00e+00	4196.00
IUUC-Tbe-127602	Tupaia belangeri	85.69	0.00e+00	974.00
IUUC-Ttr-128394	Tursiops truncatus	74.48	0.00e+00	1247.00
IUUC-Vpa-130280	Vicugna pacos	86.25	0.00e+00	2562.00
IUUC-Xtr-131787	Xenopus tropicalis	81.07	0.00e+00	2650.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence