iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064186

Ensembl Protein ID

ENSMUSP00000130560.1

UniProt Accession

E9Q5R6; E9Q5R6_MOUSE

Genbank Protein ID

ENSMUSP00000130560

Protein Name

Rho guanine nucleotide exchange factor 37

Genbank Nucleotide ID

AC153155

Gene Name

Arhgef37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000045094.7	ENSMUST00000171629.1	ENSMUSP00000130560.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.60e-12	47.6	605	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvek 61
           + +v + y++ a ++ eL+l++G  v+++  ++++ + +W     e++g+rG +P+nF ++
   Q: 605  MSQVVAVYPFVARSTHELSLQAGQPVTILeaQDKKGNPEWSLV--EANGQRGYVPSNFLAR 663
           67899************************9889999****977..9************987 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHMLR LCASDIRSHL 60
QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA HLIGNLFLEF QEEFEQVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCTTCCC AGAGCCGGGC AGCTGGAGCC CAGCGGGTGC AAGTGACTCC GGAGGGCATC 60
CGGCGCGTGC GCGGTGAGTC CAGCCCGGCG ACGGCGACAG GATGCCGCCA GGAGGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF03114--BAR
PF00621--RhoGEF
PF07653--SH3_2
PF14604--SH3_9

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction

KEGG

mmu:328967

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	38.18	1.00e-123	437.00
IUUC-Bta-012848	Bos taurus	77.96	0.00e+00	1017.00
IUUC-Cfa-021281	Canis familiaris	77.81	0.00e+00	1031.00
IUUC-Csa-023043	Chlorocebus sabaeus	79.44	0.00e+00	1046.00
IUUC-Dre-028496	Danio rerio	40.49	5.00e-129	454.00
IUUC-Ggo-044900	Gorilla gorilla	79.29	0.00e+00	1055.00
IUUC-Hsa-045684	Homo sapiens	79.44	0.00e+00	1085.00
IUUC-Lch-050096	Latimeria chalumnae	46.35	2.00e-160	559.00
IUUC-Loc-051937	Lepisosteus oculatus	40.92	3.00e-131	462.00
IUUC-Mcc-054950	Macaca mulatta	79.14	0.00e+00	1043.00
IUUC-Meu-056383	Macropus eugenii	63.96	1.00e-163	570.00
IUUC-Mdo-062021	Monodelphis domestica	64.25	0.00e+00	842.00
IUUC-Ptr-090508	Pan troglodytes	78.99	0.00e+00	1051.00
IUUC-Pan-092517	Papio anubis	79.14	0.00e+00	1029.00
IUUC-Pfo-096703	Poecilia formosa	37.67	4.00e-121	429.00
IUUC-Pab-098542	Pongo abelii	79.29	0.00e+00	1053.00
IUUC-Rno-105455	Rattus norvegicus	91.57	0.00e+00	1209.00
IUUC-Sha-106562	Sarcophilus harrisii	63.09	0.00e+00	851.00
IUUC-Ttr-128242	Tursiops truncatus	75.15	0.00e+00	985.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence