iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106744

Ensembl Protein ID

ENSSHAP00000015853.1

UniProt Accession

G3WK98; G3WK98_SARHA

Genbank Protein ID

ENSSHAP00000015853

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01232862

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000013506.1	ENSSHAT00000015982.1	ENSSHAP00000015853.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.40e-13	48.2	216	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +lydy++ n ++L+l+kG+  l++  ee    W+++ ++ +g++G +P+n+v+++e
   Q: 216  LKRVVALYDYTPMNANDLQLQKGEEYLIL--EESTLPWWRA-RDKNGREGYIPNNYVTEAE 273
           6899************************9..888899****.6***************987 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSVDVEK 60
ITCVETVVPE KNPPPERQIP RKGEEASEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGACCCGT CTCTCTCCCT CTCTCTCCCT GCCCTGCCCC CCCCCCCATT TCTGCATTTC 60
TCCTTTCTCT CTGCCTGCCC ATTCCTGCAA TCTTGAAACC ACCTTCGTGG CCTGGCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00402--TECBTKDOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

KEGG

shr:100929183

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	93.47	0.00e+00	1248.00
IUUC-Apl-003907	Anas platyrhynchos	86.26	0.00e+00	1139.00
IUUC-Aca-004978	Anolis carolinensis	76.10	0.00e+00	1050.00
IUUC-Ame-010694	Astyanax mexicanus	56.98	1.00e-151	529.00
IUUC-Bta-012467	Bos taurus	93.63	0.00e+00	1250.00
IUUC-Cja-018841	Callithrix jacchus	92.87	0.00e+00	1239.00
IUUC-Cfa-020983	Canis familiaris	93.63	0.00e+00	1228.00
IUUC-Cpo-021307	Cavia porcellus	93.78	0.00e+00	1251.00
IUUC-Csa-023508	Chlorocebus sabaeus	92.35	0.00e+00	931.00
IUUC-Dre-028544	Danio rerio	57.46	2.00e-147	514.00
IUUC-Dno-029828	Dasypus novemcinctus	92.72	0.00e+00	1226.00
IUUC-Dor-030102	Dipodomys ordii	85.95	0.00e+00	1031.00
IUUC-Ete-032981	Echinops telfairi	85.89	0.00e+00	1122.00
IUUC-Eca-033594	Equus caballus	93.93	0.00e+00	1252.00
IUUC-Eeu-035281	Erinaceus europaeus	88.77	0.00e+00	982.00
IUUC-Fca-035495	Felis catus	93.17	0.00e+00	1222.00
IUUC-Fal-036719	Ficedula albicollis	86.04	0.00e+00	1170.00
IUUC-Gga-041193	Gallus gallus	86.19	0.00e+00	1147.00
IUUC-Gac-042383	Gasterosteus aculeatus	45.97	6.00e-128	450.00
IUUC-Hsa-045931	Homo sapiens	93.63	0.00e+00	1231.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	93.78	0.00e+00	1251.00
IUUC-Lch-049868	Latimeria chalumnae	75.38	0.00e+00	985.00
IUUC-Loc-052730	Lepisosteus oculatus	56.85	9.00e-162	563.00
IUUC-Laf-053516	Loxodonta africana	93.04	0.00e+00	1268.00
IUUC-Mcc-054795	Macaca mulatta	93.63	0.00e+00	1231.00
IUUC-Meu-056157	Macropus eugenii	86.80	0.00e+00	1112.00
IUUC-Mga-059529	Meleagris gallopavo	85.82	0.00e+00	977.00
IUUC-Mmr-060824	Microcebus murinus	89.38	0.00e+00	1155.00
IUUC-Mdo-063036	Monodelphis domestica	96.87	0.00e+00	1266.00
IUUC-Mmu-064047	Mus musculus	93.32	0.00e+00	1247.00
IUUC-Mpu-066810	Mustela putorius furo	93.63	0.00e+00	1249.00
IUUC-Mlu-067671	Myotis lucifugus	92.61	0.00e+00	1237.00
IUUC-Nle-069108	Nomascus leucogenys	93.63	0.00e+00	1231.00
IUUC-Opr-070505	Ochotona princeps	73.18	0.00e+00	647.00
IUUC-Ont-072585	Oreochromis niloticus	59.50	4.00e-164	570.00
IUUC-Oan-073495	Ornithorhynchus anatinus	92.11	0.00e+00	1253.00
IUUC-Ocu-074416	Oryctolagus cuniculus	93.63	0.00e+00	1248.00
IUUC-Ola-086938	Oryzias latipes	58.60	5.00e-157	546.00
IUUC-Oga-088995	Otolemur garnettii	92.45	0.00e+00	1218.00
IUUC-Oar-089632	Ovis aries	92.87	0.00e+00	1228.00
IUUC-Ptr-090941	Pan troglodytes	93.47	0.00e+00	1229.00
IUUC-Pan-091900	Papio anubis	90.59	0.00e+00	1182.00
IUUC-Psi-093048	Pelodiscus sinensis	85.17	0.00e+00	1113.00
IUUC-Pfo-096955	Poecilia formosa	59.58	1.00e-163	569.00
IUUC-Pab-097587	Pongo abelii	93.63	0.00e+00	1231.00
IUUC-Pca-100374	Procavia capensis	83.89	4.00e-141	494.00
IUUC-Pva-102583	Pteropus vampyrus	93.17	0.00e+00	1219.00
IUUC-Rno-104868	Rattus norvegicus	88.67	0.00e+00	1163.00
IUUC-Sar-113041	Sorex araneus	93.04	0.00e+00	1087.00
IUUC-Ssc-115294	Sus scrofa	93.47	0.00e+00	1248.00
IUUC-Tgu-116458	Taeniopygia guttata	53.39	0.00e+00	719.00
IUUC-Tsy-118945	Tarsius syrichta	92.67	0.00e+00	827.00
IUUC-Ttr-128769	Tursiops truncatus	84.22	0.00e+00	1114.00
IUUC-Vpa-130517	Vicugna pacos	88.52	0.00e+00	703.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence