iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062544

UUCD1 version

UUC-MoD-01097

Ensembl Protein ID

ENSMODP00000025726.1

UniProt Accession

P50103; F7APK9; UCHL1_MONDO

Genbank Protein ID

AAA89059.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L1; Neuron cytoplasmic protein 9.5; PGP 9.5; Ubiquitin thioesterase L1

Genbank Nucleotide ID

U32208

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000020568.3	ENSMODT00000026186.2	ENSMODP00000025726.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.10e-59	202.6	2	221

Active Site

Position(s)	Description	Evidence
90	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
161	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           ++ ++e +P+++++++ ++gv +d+++ ++ +L+++ lg+++ p ++llllF+++ ++e++rk+q++    e +++++  +++f+kq++
   Q: 2    QLKPMEINPEMLNKVLTRLGVGGDWKFVDVLGLEEDVLGTVPAPACALLLLFPLTAQHENFRKKQIE----ELKGQEVSPKVYFMKQTV 86
           5789*************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           gNsC+t++l+++++n++dkl +d G+ l+++ ++t + spe++a++++++++++++h+++a++++++ +          ++ +fhf+++
   Q: 87   GNSCGTIGLIHAVANNQDKLnFDDGSVLKQFISETAKLSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVD----------DEVNFHFILF 165
           *******************************************************************99..........4569****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
            n++g+lyeldg++pfP+++g+ +++  lk +++ +r+f+er    e++e+rf+++a+++
   Q: 166  NNVDGHLYELDGRMPFPINHGSNSDESVLKGAAEICRQFTER----EEGEVRFSAVALCK 221
           ******************************************....***********986 PP

Organism

Monodelphis domestica

Functional Description
(View)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity).

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLTRL GVGGDWKFVD VLGLEEDVLG TVPAPACALL LLFPLTAQHE 60
NFRKKQIEEL KGQEVSPKVY FMKQTVGNSC GTIGLIHAVA NNQDKLNFDD GSVLKQFISE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTGCCCAA GGTCACCCAG CTGAGACGTA TCTGAGGCTG GATTTAAACT TGAATGTTCC 60
AGACTTCAGG TCCAGTGTTC CATCCATTGC AACACCCAAG TGCCCTGAAC GTCGTCATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0436--Ligase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0636--Prenylation
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100015629

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	72.66	4.00e-104	370.00
IUUC-Apl-003693	Anas platyrhynchos	68.75	2.00e-89	321.00
IUUC-Aca-004716	Anolis carolinensis	74.55	1.00e-100	358.00
IUUC-Ame-011806	Astyanax mexicanus	64.86	3.00e-82	297.00
IUUC-Bta-013521	Bos taurus	74.21	5.00e-106	377.00
IUUC-Bci-013734	Botrytis cinerea	36.52	1.00e-34	140.00
IUUC-Cel-018302	Caenorhabditis elegans	35.81	1.00e-32	132.00
IUUC-Cja-018752	Callithrix jacchus	87.05	2.00e-108	384.00
IUUC-Cfa-020442	Canis familiaris	87.05	7.00e-108	382.00
IUUC-Cpo-021723	Cavia porcellus	87.35	2.00e-87	314.00
IUUC-Csa-023626	Chlorocebus sabaeus	87.44	4.00e-109	386.00
IUUC-Cho-024548	Choloepus hoffmanni	80.56	3.00e-38	150.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	31.06	8.00e-26	110.00
IUUC-Cme-027216	Cyanidioschyzon merolae	33.77	6.00e-19	87.40
IUUC-Dre-027854	Danio rerio	62.33	1.00e-79	289.00
IUUC-Dno-029325	Dasypus novemcinctus	86.55	5.00e-109	386.00
IUUC-Dor-030114	Dipodomys ordii	85.20	6.00e-117	412.00
IUUC-Dse-031461	Dothistroma septosporum	34.33	6.00e-29	120.00
IUUC-Ete-033092	Echinops telfairi	70.85	5.00e-90	323.00
IUUC-Eca-033854	Equus caballus	85.92	1.00e-72	264.00
IUUC-Eeu-034493	Erinaceus europaeus	85.20	4.00e-105	373.00
IUUC-Fal-036693	Ficedula albicollis	72.38	3.00e-90	324.00
IUUC-Fox-037830	Fusarium oxysporum	37.89	4.00e-35	141.00
IUUC-Fso-038259	Fusarium solani	35.68	4.00e-32	133.00
IUUC-Gmo-038848	Gadus morhua	60.38	1.00e-73	268.00
IUUC-Gga-041078	Gallus gallus	73.66	2.00e-99	354.00
IUUC-Gac-042064	Gasterosteus aculeatus	59.09	2.00e-75	274.00
IUUC-Ggo-044827	Gorilla gorilla	87.89	5.00e-110	389.00
IUUC-Hsa-045820	Homo sapiens	87.89	5.00e-110	389.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	87.89	2.00e-109	388.00
IUUC-Lch-050121	Latimeria chalumnae	69.82	3.00e-93	333.00
IUUC-Loc-052342	Lepisosteus oculatus	66.81	5.00e-89	320.00
IUUC-Laf-053916	Loxodonta africana	85.27	2.00e-106	378.00
IUUC-Mcc-054838	Macaca mulatta	87.44	4.00e-109	386.00
IUUC-Meu-056478	Macropus eugenii	96.41	1.00e-127	448.00
IUUC-Mpo-057343	Magnaporthe poae	28.88	6.00e-16	77.00
IUUC-Mga-059878	Meleagris gallopavo	72.35	4.00e-93	333.00
IUUC-Mmu-063300	Mus musculus	86.55	2.00e-118	417.00
IUUC-Mpu-066128	Mustela putorius furo	87.50	7.00e-96	343.00
IUUC-Mlu-067778	Myotis lucifugus	87.33	5.00e-118	416.00
IUUC-Nle-069686	Nomascus leucogenys	88.34	3.00e-110	390.00
IUUC-Opr-070535	Ochotona princeps	70.85	9.00e-92	329.00
IUUC-Ont-071510	Oreochromis niloticus	59.91	2.00e-77	281.00
IUUC-Ocu-074590	Oryctolagus cuniculus	87.00	3.00e-109	387.00
IUUC-Ola-087552	Oryzias latipes	56.83	1.00e-71	262.00
IUUC-Oga-089013	Otolemur garnettii	72.62	4.00e-103	367.00
IUUC-Oar-089861	Ovis aries	74.21	4.00e-106	377.00
IUUC-Ptr-091536	Pan troglodytes	86.10	1.00e-107	381.00
IUUC-Pan-092909	Papio anubis	87.44	4.00e-109	386.00
IUUC-Psi-093818	Pelodiscus sinensis	79.46	1.00e-104	372.00
IUUC-Pfo-097335	Poecilia formosa	57.14	5.00e-75	273.00
IUUC-Pab-098048	Pongo abelii	87.89	5.00e-110	389.00
IUUC-Pca-100818	Procavia capensis	67.18	1.00e-61	228.00
IUUC-Pva-102954	Pteropus vampyrus	87.44	2.00e-105	374.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	35.58	2.00e-29	122.00
IUUC-Rno-105966	Rattus norvegicus	86.55	2.00e-118	417.00
IUUC-Sha-107111	Sarcophilus harrisii	96.36	9.00e-93	332.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	36.48	1.00e-32	133.00
IUUC-Sar-113190	Sorex araneus	66.67	2.00e-35	140.00
IUUC-Ssc-115908	Sus scrofa	72.89	3.00e-93	334.00
IUUC-Tgu-117465	Taeniopygia guttata	68.25	6.00e-84	303.00
IUUC-Tru-118565	Takifugu rubripes	58.62	4.00e-67	247.00
IUUC-Tsy-119561	Tarsius syrichta	70.85	1.00e-89	322.00
IUUC-Tre-122149	Trichoderma reesei	40.09	2.00e-38	152.00
IUUC-Tvi-122450	Trichoderma virens	38.33	3.00e-37	148.00
IUUC-Tme-126961	Tuber melanosporum	35.50	1.00e-30	126.00
IUUC-Tbe-128048	Tupaia belangeri	87.27	4.00e-87	313.00
IUUC-Ttr-128494	Tursiops truncatus	86.43	3.00e-105	374.00
IUUC-Vda-129850	Verticillium dahliae	33.91	2.00e-28	118.00
IUUC-Xtr-132286	Xenopus tropicalis	69.06	7.00e-92	329.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence