iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069148

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01106379

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000007885.2	ENSNLET00000032183.1	ENSNLEP00000023803.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.30e-59	200.4	55	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+N+g tC +NS++Q+ ++  ++++ l++   ++  n     e+  ++  ++  l+e++++s++kav p el  +l+k+++    + 
   Q: 55   VGLHNIGQTCCLNSLIQVFVMNVDFTRILKRiTVPRGAN-----EQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKYNVP--LFV 136
           6******************************44444444.....5677999*******************************99..79* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           q+Da  +   l + +++++                          ++ +  + ++ l+ +q+k++++cl+c+ +ssr++++l+l+l++ 
   Q: 137  QHDAAQLYLKLWNLIKDQI--------------------------TDVHLVERLQALYMIQMKDSLICLDCAMESSRNSSMLTLPLSLF 199
           *******************..........................67788899************************************ PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fc 265
           + +++ +++l+d+L+ f+++ el ++ k++ce+c kk++ ++ lkl++lP++L++hL+Rf  ++  ++ +ki  +++fp++Ld s+   
   Q: 200  DVNSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFAIRN--SQTRKICHSLYFPQSLDFSQvLP 286
           ************************************************************6655..6888***************6333 PP
   S: 266  tspeekqke...kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.......staYvlfYkrr 338
            +pe+ ++e     +YeL+av+ H G ++sGHY++y++n  ++ W++f+Ds++  v++e+++ + g       +taY+l+Y+++
   Q: 287  MKPESCDAEeqsGGQYELFAVIAHVGMADSGHYCVYIRNAADRkWFCFNDSNICLVSWEDIQCTYGnpnyhwqETAYLLVYMKM 370
           333333333333899************************65555*******************888***************986 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSKVFGLLRQ TWQSILAASP QSPADLEEKK EEDSNMKTEQ PRERPRAWDY PHGLVGLHNI 60
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GANEQRRSVP FQMLLLLEKM QDSRQKAVRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTAAAATA CAAAACTTAG CCAGGAGTGG TGGCGCATGC CTGTAATCCC AGCTACTCCG 60
GAGGCTGAGG CAGGAGAATT TCTTGAACCC AGGAGGCGGA GTTTGCAGTG AACCGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

nle:100583021

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	75.99	8.00e-156	542.00
IUUC-Apl-004006	Anas platyrhynchos	56.88	1.00e-105	375.00
IUUC-Aca-005088	Anolis carolinensis	53.54	8.00e-91	327.00
IUUC-Ame-010606	Astyanax mexicanus	32.17	5.00e-38	151.00
IUUC-Bta-013036	Bos taurus	75.55	1.00e-147	515.00
IUUC-Cja-019052	Callithrix jacchus	82.97	2.00e-157	548.00
IUUC-Cfa-020554	Canis familiaris	80.00	1.00e-162	565.00
IUUC-Cpo-022421	Cavia porcellus	71.20	2.00e-155	541.00
IUUC-Csa-023737	Chlorocebus sabaeus	92.16	3.00e-114	403.00
IUUC-Cho-024807	Choloepus hoffmanni	69.39	2.00e-70	258.00
IUUC-Dre-027408	Danio rerio	31.07	7.00e-43	167.00
IUUC-Dno-029813	Dasypus novemcinctus	66.58	1.00e-127	449.00
IUUC-Dor-030532	Dipodomys ordii	71.66	2.00e-158	551.00
IUUC-Ete-032254	Echinops telfairi	69.81	7.00e-155	539.00
IUUC-Eca-033482	Equus caballus	81.50	9.00e-159	552.00
IUUC-Eeu-034451	Erinaceus europaeus	72.99	3.00e-93	333.00
IUUC-Fca-036313	Felis catus	81.85	6.00e-162	563.00
IUUC-Fal-037216	Ficedula albicollis	52.66	6.00e-105	374.00
IUUC-Gmo-038649	Gadus morhua	31.75	1.00e-39	156.00
IUUC-Gga-041082	Gallus gallus	54.29	1.00e-94	339.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.19	6.00e-52	197.00
IUUC-Ggo-044957	Gorilla gorilla	96.34	9.00e-159	551.00
IUUC-Hsa-046381	Homo sapiens	95.16	0.00e+00	741.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	77.36	6.00e-170	589.00
IUUC-Loc-052688	Lepisosteus oculatus	33.23	2.00e-47	182.00
IUUC-Laf-054109	Loxodonta africana	77.48	1.00e-176	612.00
IUUC-Mcc-054814	Macaca mulatta	92.51	0.00e+00	723.00
IUUC-Meu-056253	Macropus eugenii	65.73	3.00e-105	374.00
IUUC-Mmr-061613	Microcebus murinus	81.68	3.00e-164	570.00
IUUC-Mdo-061890	Monodelphis domestica	62.80	2.00e-118	418.00
IUUC-Mmu-064329	Mus musculus	69.38	4.00e-142	497.00
IUUC-Mpu-066342	Mustela putorius furo	81.02	2.00e-164	571.00
IUUC-Mlu-067010	Myotis lucifugus	75.55	2.00e-163	568.00
IUUC-Opr-070988	Ochotona princeps	71.34	2.00e-66	246.00
IUUC-Ont-072039	Oreochromis niloticus	33.44	2.00e-47	182.00
IUUC-Oan-073740	Ornithorhynchus anatinus	57.35	7.00e-76	276.00
IUUC-Ocu-074498	Oryctolagus cuniculus	74.53	4.00e-153	533.00
IUUC-Ola-086753	Oryzias latipes	35.03	8.00e-47	180.00
IUUC-Oga-088497	Otolemur garnettii	78.21	2.00e-169	588.00
IUUC-Oar-089505	Ovis aries	75.24	3.00e-147	514.00
IUUC-Ptr-091656	Pan troglodytes	94.62	0.00e+00	737.00
IUUC-Pan-092498	Papio anubis	92.25	0.00e+00	717.00
IUUC-Psi-093409	Pelodiscus sinensis	54.08	4.00e-110	391.00
IUUC-Pfo-096507	Poecilia formosa	33.97	2.00e-46	179.00
IUUC-Pab-097828	Pongo abelii	94.12	0.00e+00	633.00
IUUC-Pca-100299	Procavia capensis	76.03	4.00e-104	371.00
IUUC-Pva-102972	Pteropus vampyrus	76.69	9.00e-162	562.00
IUUC-Rno-105738	Rattus norvegicus	69.27	8.00e-150	523.00
IUUC-Sha-107309	Sarcophilus harrisii	62.19	1.00e-112	399.00
IUUC-Sar-112983	Sorex araneus	72.38	2.00e-118	418.00
IUUC-Ssc-116049	Sus scrofa	76.18	1.00e-150	525.00
IUUC-Tgu-117115	Taeniopygia guttata	55.70	5.00e-103	367.00
IUUC-Tru-118022	Takifugu rubripes	32.08	1.00e-41	163.00
IUUC-Tsy-118986	Tarsius syrichta	63.03	2.00e-63	235.00
IUUC-Tni-120306	Tetraodon nigroviridis	31.96	7.00e-40	157.00
IUUC-Tbe-127768	Tupaia belangeri	69.80	7.00e-117	413.00
IUUC-Ttr-128686	Tursiops truncatus	74.05	2.00e-150	525.00
IUUC-Xtr-132032	Xenopus tropicalis	42.77	7.00e-70	257.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence