iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089483

Ensembl Protein ID

ENSOARP00000000833.1

UniProt Accession

W5NRP3; W5NRP3_SHEEP

Genbank Protein ID

ENSOARP00000000833

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AMGL01027921

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000804.1	ENSOART00000000866.1	ENSOARP00000000833.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-45	151.3	145	180
UBD/Beta-Prp	1.00e-59	202.3	15	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+s+ f p++  l+sg +D s+r++  
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSILFNPDGCCLYSGCQD-SLRVYGW 259
           ***********************************************************765.5666544 PP

Organism

Ovis aries

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACCC CTGTGGTCAC CAAGACGGCC TGGAAGTTGC GTGAGTGGCT TGCTTTTTTA 60
CCCCATTTAT CCCGGTAGCT GTTTGTTGGT GGGTGGCCTG GACTTCAACT TTGTCTCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR002469--Peptidase_S9B_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.84	4.00e-84	306.00
IUUC-Aml-002187	Ailuropoda melanoleuca	89.08	0.00e+00	1103.00
IUUC-Atr-002899	Amborella trichopoda	54.11	1.00e-100	360.00
IUUC-Apl-003305	Anas platyrhynchos	75.95	0.00e+00	981.00
IUUC-Aca-004635	Anolis carolinensis	78.17	0.00e+00	937.00
IUUC-Aly-005711	Arabidopsis lyrata	51.16	1.00e-99	357.00
IUUC-Ath-007606	Arabidopsis thaliana	51.16	1.00e-99	357.00
IUUC-Ame-010870	Astyanax mexicanus	55.73	2.00e-97	349.00
IUUC-Bta-012527	Bos taurus	97.29	0.00e+00	1214.00
IUUC-Bdi-014652	Brachypodium distachyon	53.18	8.00e-102	365.00
IUUC-Bol-015242	Brassica oleracea	50.17	1.00e-97	351.00
IUUC-Bra-017390	Brassica rapa	50.50	3.00e-98	353.00
IUUC-Cja-019706	Callithrix jacchus	92.93	0.00e+00	1072.00
IUUC-Cfa-020139	Canis familiaris	78.90	0.00e+00	749.00
IUUC-Cpo-021710	Cavia porcellus	92.01	0.00e+00	1136.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.47	3.00e-68	253.00
IUUC-Csa-023546	Chlorocebus sabaeus	93.97	0.00e+00	1028.00
IUUC-Cin-025156	Ciona intestinalis	40.87	5.00e-151	528.00
IUUC-Csv-025962	Ciona savignyi	49.32	3.00e-88	318.00
IUUC-Dre-028215	Danio rerio	61.26	0.00e+00	830.00
IUUC-Dno-029314	Dasypus novemcinctus	92.16	0.00e+00	1094.00
IUUC-Dor-030482	Dipodomys ordii	92.76	0.00e+00	1177.00
IUUC-Dme-032188	Drosophila melanogaster	39.48	4.00e-57	216.00
IUUC-Eca-034143	Equus caballus	93.21	0.00e+00	1166.00
IUUC-Fca-035924	Felis catus	94.12	0.00e+00	1139.00
IUUC-Fal-037387	Ficedula albicollis	76.54	0.00e+00	962.00
IUUC-Gmo-038692	Gadus morhua	61.76	3.00e-145	508.00
IUUC-Gga-040597	Gallus gallus	77.22	0.00e+00	1015.00
IUUC-Gac-042004	Gasterosteus aculeatus	59.73	0.00e+00	804.00
IUUC-Gma-044134	Glycine max	52.49	5.00e-99	355.00
IUUC-Ggo-044761	Gorilla gorilla	94.42	0.00e+00	1069.00
IUUC-Hsa-045698	Homo sapiens	94.12	0.00e+00	1096.00
IUUC-Hvu-047649	Hordeum vulgare	52.92	5.00e-102	365.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	92.01	0.00e+00	1119.00
IUUC-Lch-049674	Latimeria chalumnae	66.81	0.00e+00	892.00
IUUC-Lpe-051597	Leersia perrieri	47.04	2.00e-92	333.00
IUUC-Loc-052623	Lepisosteus oculatus	64.95	0.00e+00	880.00
IUUC-Laf-054587	Loxodonta africana	93.97	0.00e+00	1154.00
IUUC-Mcc-055851	Macaca mulatta	94.27	0.00e+00	1069.00
IUUC-Meu-056704	Macropus eugenii	88.54	0.00e+00	1154.00
IUUC-Mtr-058053	Medicago truncatula	52.16	1.00e-102	367.00
IUUC-Mga-059608	Meleagris gallopavo	76.40	0.00e+00	999.00
IUUC-Mmr-061154	Microcebus murinus	91.74	0.00e+00	1093.00
IUUC-Mdo-062365	Monodelphis domestica	84.81	0.00e+00	1086.00
IUUC-Mmu-063754	Mus musculus	91.59	0.00e+00	1116.00
IUUC-Mac-064667	Musa acuminata	52.04	7.00e-99	353.00
IUUC-Mpu-066245	Mustela putorius furo	93.21	0.00e+00	1102.00
IUUC-Mlu-067692	Myotis lucifugus	93.45	0.00e+00	1112.00
IUUC-Nle-070051	Nomascus leucogenys	91.72	0.00e+00	1053.00
IUUC-Opr-070855	Ochotona princeps	92.31	0.00e+00	1134.00
IUUC-Ont-071883	Oreochromis niloticus	57.56	0.00e+00	806.00
IUUC-Oan-073293	Ornithorhynchus anatinus	87.58	0.00e+00	999.00
IUUC-Ocu-074644	Oryctolagus cuniculus	93.36	0.00e+00	1151.00
IUUC-Oba-075448	Oryza barthii	54.52	2.00e-104	374.00
IUUC-Obr-076385	Oryza brachyantha	53.51	1.00e-103	370.00
IUUC-Ogl-077427	Oryza glaberrima	54.52	6.00e-105	375.00
IUUC-Ogu-079022	Oryza glumaepatula	48.56	6.00e-96	345.00
IUUC-Oin-079811	Oryza indica	52.09	1.00e-101	364.00
IUUC-Olo-080245	Oryza longistaminata	52.09	1.00e-101	364.00
IUUC-Ome-081239	Oryza meridionalis	53.92	4.00e-101	362.00
IUUC-Oni-082640	Oryza nivara	54.52	2.00e-104	374.00
IUUC-Opu-083748	Oryza punctata	50.00	3.00e-104	373.00
IUUC-Oru-084609	Oryza rufipogon	54.52	2.00e-104	374.00
IUUC-Osa-086267	Oryza sativa	48.56	5.00e-96	345.00
IUUC-Ola-087483	Oryzias latipes	54.72	2.00e-178	619.00
IUUC-Oga-087964	Otolemur garnettii	92.16	0.00e+00	1151.00
IUUC-Ptr-091387	Pan troglodytes	94.27	0.00e+00	1098.00
IUUC-Pan-092623	Papio anubis	94.27	0.00e+00	1069.00
IUUC-Psi-093830	Pelodiscus sinensis	79.64	0.00e+00	1021.00
IUUC-Pma-094135	Petromyzon marinus	43.90	2.00e-39	155.00
IUUC-Ppa-095379	Physcomitrella patens	54.45	7.00e-96	345.00
IUUC-Pfo-096755	Poecilia formosa	56.69	0.00e+00	783.00
IUUC-Pab-097564	Pongo abelii	92.89	0.00e+00	939.00
IUUC-Pop-099149	Populus trichocarpa	52.16	3.00e-102	366.00
IUUC-Pca-100357	Procavia capensis	99.52	4.00e-126	444.00
IUUC-Ppe-101237	Prunus persica	52.16	6.00e-102	365.00
IUUC-Pva-102397	Pteropus vampyrus	89.74	0.00e+00	1051.00
IUUC-Rno-105349	Rattus norvegicus	91.86	0.00e+00	1159.00
IUUC-Smo-109379	Selaginella moellendorffii	53.92	3.00e-99	356.00
IUUC-Sit-110360	Setaria italica	54.52	2.00e-104	373.00
IUUC-Sly-111307	Solanum lycopersicum	52.84	1.00e-97	350.00
IUUC-Stu-112462	Solanum tuberosum	52.05	6.00e-94	338.00
IUUC-Sar-112953	Sorex araneus	80.80	2.00e-105	376.00
IUUC-Sbi-114389	Sorghum bicolor	46.64	3.00e-92	333.00
IUUC-Ssc-115949	Sus scrofa	92.51	0.00e+00	876.00
IUUC-Tgu-117461	Taeniopygia guttata	76.46	0.00e+00	996.00
IUUC-Tru-117865	Takifugu rubripes	56.66	0.00e+00	771.00
IUUC-Tsy-119036	Tarsius syrichta	75.89	4.00e-75	275.00
IUUC-Tni-120903	Tetraodon nigroviridis	59.34	0.00e+00	759.00
IUUC-Tca-121185	Theobroma cacao	51.16	3.00e-99	356.00
IUUC-Tae-125263	Triticum aestivum	53.25	4.00e-102	366.00
IUUC-Tur-126181	Triticum urartu	47.62	1.00e-92	334.00
IUUC-Tbe-127518	Tupaia belangeri	77.53	4.00e-178	618.00
IUUC-Ttr-128172	Tursiops truncatus	93.67	0.00e+00	1117.00
IUUC-Vvi-131489	Vitis vinifera	52.82	1.00e-102	367.00
IUUC-Xtr-132915	Xenopus tropicalis	70.47	0.00e+00	933.00
IUUC-Xma-134133	Xiphophorus maculatus	56.43	0.00e+00	773.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence