iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046576

UUCD1 version

UUC-HoS-01182

Ensembl Protein ID

ENSP00000303709.3

UniProt Accession

P51965; B2RBX4; C9J8K2; K4DI90; UB2E1_HUMAN

Genbank Protein ID

CAA63539.1; BAG37371.1; EAW64329.1; EAW64331.1; EAW64332.1; AAH09139.1; ENSP00000303709

Protein Name

Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1

Genbank Nucleotide ID

X92963; AK314854; AC020626; CH471055; CH471055; BC009139; BI223271

Gene Name

UBE2E1; UBCH6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170142.11	ENST00000306627.7	ENSP00000303709.3
ENSG00000170142.11	ENST00000346855.7	ENSP00000329113.4
ENSG00000170142.11	ENST00000467766.5	ENSP00000475890.1
ENSG00000170142.11	ENST00000424381.5	ENSP00000411351.1
ENSG00000170142.11	ENST00000452012.1	ENSP00000393088.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20145714; 19592251; 16243356; 18597043; 17222803; 16314844; 19358823; 18363970; 11823428

Classification

Family	E-value	Score	Start	End
E2/UBC	1.00e-49	169.5	51	186

Active Site

Position(s)	Description	Evidence
131	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f+++YPfkPPkv+f t+i+h+n++++G +Cl+ilk  ++W
   Q: 51   RIQKELADITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILK--DNW 139
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           spal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 140  SPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQ 186
           ******************************************99985 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT 60
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGCG GAGGAGTGGT GTGTGTGCGA GCGTGTGTGG CTGGGGGAAG CCATTGCCTG 60
TTTAATAGTT GCTGTTGCTG CACTTCCGCT TCTCTCCCAG CGAGAGAGAG ACACGAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0032020--P:ISG15-protein conjugation
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001532	Ailuropoda melanoleuca	100.00	9.00e-94	335.00
IUUC-Apl-004207	Anas platyrhynchos	99.43	5.00e-93	333.00
IUUC-Aca-005103	Anolis carolinensis	99.43	3.00e-93	334.00
IUUC-Cja-019311	Callithrix jacchus	100.00	1.00e-93	335.00
IUUC-Cfa-020017	Canis familiaris	100.00	1.00e-93	335.00
IUUC-Cpo-022266	Cavia porcellus	100.00	1.00e-93	335.00
IUUC-Csa-023538	Chlorocebus sabaeus	100.00	1.00e-93	335.00
IUUC-Cin-025161	Ciona intestinalis	84.38	1.00e-75	275.00
IUUC-Csv-025982	Ciona savignyi	84.38	3.00e-82	297.00
IUUC-Dno-029441	Dasypus novemcinctus	100.00	4.00e-75	272.00
IUUC-Dor-030450	Dipodomys ordii	100.00	5.00e-64	235.00
IUUC-Ete-032397	Echinops telfairi	98.29	5.00e-101	359.00
IUUC-Fca-035467	Felis catus	100.00	8.00e-94	335.00
IUUC-Fal-036907	Ficedula albicollis	99.43	3.00e-93	334.00
IUUC-Gga-040403	Gallus gallus	99.43	3.00e-93	334.00
IUUC-Gac-042007	Gasterosteus aculeatus	92.22	3.00e-80	290.00
IUUC-Ggo-045507	Gorilla gorilla	100.00	1.00e-93	335.00
IUUC-Itr-048197	Ictidomys tridecemlineatus	100.00	4.00e-75	272.00
IUUC-Lch-050322	Latimeria chalumnae	95.43	4.00e-98	350.00
IUUC-Laf-054313	Loxodonta africana	100.00	1.00e-93	335.00
IUUC-Meu-056590	Macropus eugenii	100.00	7.00e-85	305.00
IUUC-Mmr-060791	Microcebus murinus	100.00	1.00e-93	335.00
IUUC-Mmu-063297	Mus musculus	98.86	1.00e-102	364.00
IUUC-Mpu-065698	Mustela putorius furo	99.43	2.00e-103	367.00
IUUC-Nle-069622	Nomascus leucogenys	100.00	1.00e-93	335.00
IUUC-Ont-071689	Oreochromis niloticus	92.44	5.00e-92	329.00
IUUC-Oan-073006	Ornithorhynchus anatinus	100.00	6.00e-75	272.00
IUUC-Ocu-074055	Oryctolagus cuniculus	100.00	1.00e-93	335.00
IUUC-Ola-086636	Oryzias latipes	92.94	3.00e-83	300.00
IUUC-Oga-088863	Otolemur garnettii	100.00	1.00e-93	335.00
IUUC-Oar-089803	Ovis aries	99.43	2.00e-103	367.00
IUUC-Ptr-090914	Pan troglodytes	100.00	1.00e-93	335.00
IUUC-Pan-092786	Papio anubis	100.00	1.00e-93	335.00
IUUC-Psi-093923	Pelodiscus sinensis	100.00	1.00e-93	335.00
IUUC-Pma-094642	Petromyzon marinus	95.24	6.00e-71	258.00
IUUC-Pfo-096966	Poecilia formosa	91.23	7.00e-83	299.00
IUUC-Pab-098614	Pongo abelii	100.00	1.00e-93	335.00
IUUC-Rno-105518	Rattus norvegicus	98.27	2.00e-100	357.00
IUUC-Sha-106897	Sarcophilus harrisii	100.00	1.00e-85	308.00
IUUC-Ssc-116298	Sus scrofa	97.96	6.00e-85	305.00
IUUC-Tgu-116958	Taeniopygia guttata	100.00	3.00e-89	320.00
IUUC-Tni-120349	Tetraodon nigroviridis	94.51	7.00e-82	296.00
IUUC-Ttr-128356	Tursiops truncatus	96.57	9.00e-89	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence